Synthèse de nouveaux revêtements polymériques plus adhérents

Le développement de revêtements à deux composantes nécessite l’ajout d’autres produits couteux afin d’augmenter leur adhérence à la surface du substrat. Ce projet de recherche portera sur le développement de nouveaux revêtements qui aura une meilleure adhérence sans ajout d’autres produits. Cela permettra à SophiChem Inc. de diminuer les couts de production de ses revêtements sans compromettre leur efficacité.  De plus les utilisateurs finaux de ces produits réduiraient de beaucoup leur temps de travail.

Oscillation-based Fuel Cell Diagnostics

In this project, we propose two diagnostic tools that can identify dynamical processes in various fuel cell operating regimes, using the difference in the time constant of these processes. For example, conductive transport of electrons is faster than diffusive transport of gasses. We oscillate current and pressure at different frequencies, and measure the cell voltage. We use the amplitude ratio and phase different of these oscillations to detect dynamical processes in the fuel cells.

A comparison of the solvent extraction of betulin and betulinic acid from tree bark with a bark oil containing a complex mixture of compounds

B. W. BioEnergy Inc. produces high-quality carbon from renewable hardwood trees (birch, alder, willow and maple) in a patent-pending torrefaction process. The trees are debarked to produce the carbon which is 10-times more effective than commercial coconut carbon. Tree bark is a waste product and currently used to fuel the torrefaction process.

Analytical chemistry method development for lignin breakdown products

The partner organization MetaMixis Inc. is attempting to use biocatalytic ways to process lignin, the second most abundant biopolymer on earth, with microbiology methods to transform lignin into fine chemicals in useful quantities within a reasonable time frame. The process and end products need to be fully characterized using analytical tools to ensure the efficiency. The end products include vanillin, vanillic acid, p-coumaric acid, syringaldehyde, syringic acid, and vanillyl alcohol.

Peripheral contribution of dehydroepiandrosterone (DHEA) in the brain steroidogenesis

DHEA is a major neurosteroids precursor, and a decrease in its serum levels have been associated with neurodegenerative diseases, especially Alzheimer's disease. Little is known about steroid hormones localization and levels in the major functional areas of the human brain and which enzymes are involved in their synthesis and inactivation. We will investigate steroids levels in these areas using matrix-assisted laser\ desorption/ionization (MALDI)-Imaging mass spectrometry and liquid chromatography coupled with tandem mass spectrometry using the monkey brain as model.

Advanced investigation of amphoteric reagent-based cyclization of peptides

Encycle Therapeutics is a Toronto-based company that develops new therapeutics for the treatment of autoimmune diseases. Our competitive edge derives from a platform technology that allows for the more efficient synthesis of macrocycle- (ringlike peptides) based therapeutics. This platform involves a proprietary reagent called aziridine aldehyde. This new technique has demonstrated significant potential for the synthesis of macrocycles, however the full utility and versatility as it applies to the development of drug-like compounds has not been fully researched.

Développement d'un produit podiatrique à base de cellulose couplée à des peptides antimicrobiens pour le contrôle des pathogènes du pied diabétique

On estime dans le monde que plus de 285M de personnes sont atteintes de diabète. Cette maladie et ses complications représentent un énorme fardeau financier pour le système de santé (et les compagnies d’assurance). D’ici 2020, les coûts reliés au diabète et sa prise en charge atteindront 16,9 milliards $ par année au Canada. Actuellement, 2,3M de Canadiens sont atteints de cette maladie et environ 345 000 développeront un ulcère diabétique au niveau des pieds.

Development of aptamer-based strip assay (Ara-Strip) and electrochemical sensor (Ara-Sens) for detection of the peanut allergens

Peanut products are known to contain allergens capable of causing severe and life threatening allergic reactions. Classically, Ara h 1, Ara h 2, and Ara h 3 are considered to be the major peanut allergens, whereas Ara h 9 is the most prevalent allergen in Mediterranean countries. Current detection methods of peanut allergens are expensive and require centralized laboratories and highly trained personnel. Hence, there is an urgent need to develop rapid, simple, economic, and reliable assays for the detection of peanut allergens.

Purification and Trapping of Biohydrogen

Solarvest has developed a cutting-edge technology that enables algae to produce hydrogen in a continuous cycle in a single vessel. The hydrogen is released along with carbon dioxide and water, and intermittently the algae needs to be permitted to carry out photosynthesis, which generates oxygen. This project entails the construction, installation and testing of a system that will separate the biohydrogen produced from these other gases, and which will purify and quantify it and allow it to be re-released on demand as a fuel or chemical feedstock.

Icephobic Coatings from UV-Curable Phosphonium Salts and Their Ice Adhesion Measurement

The project will manufacture new coatings that will repel ice. These coatings can be applied onto metal, wood, glass, etc, and in particular can aid in the prevention of ice build-up on wind-power turbines. The coatings will be comprised of new materials that have not been applied as ice-repellent (or water repellent) coatings before. In addition a device to measure the adhesion of ice to the coating will be developed.