Radiation Modulated Nanomedicine Delivery

The current survival times for breast cancer patients with brain metastasis range from 2 to 16 months suggesting a strong need for improvements in their therapeutic care. Although radiation therapy is the standard of care for these patients, combination with chemotherapy has demonstrated promising therapeutic benefits. The hypothesis of this research program is based on the belief that optimizing combination of radiation and chemotherapy has the potential to significantly improve the treatment outcome for patients with breast cancers that have metastasized to the brain.

The use of inertial measurement units to quantify sport-specific movement patterns in elite sprint kayak athletes

Canoe kayak athletes use difficult body movements to move their boats at fast speeds. It has been hard to measure body movements that are needed to win paddling races in the past. Wearable devices are now able to measure athlete’s body movements when they are paddling. The goal of this research is to learn new ways to give athletes information about their movements so they can be better at their sport. The intern will learn how to use the wearable devices to help the athlete’s become faster paddlers.

Using multivariate deep-learning algorithms for automatic quality control of high-resolution MRI

NeuroRx is an imaging contract research organization (CRO) specialized in the central nervous system (CNS). This company utilizes state-of-the-art digital image processing techniques to produce accurate and precise outcome measures for clinical trials of drugs in development. Prior to analysis, all scans must pass Quality Control (QC). The goal of my project is to incorporate advanced computer algorithms to automatically classify the quality of high-resolution structural brain Magnetic Resonance Images. The advanced computer algorithms will include deep learning algorithms.

Feasibility Study of a TV-Based Video Chat Technology for Elderly with Dementia

According to the Canadian Institute for Health Information, many of Canada's increasing aging population experience physical and cognitive impairments that necessitate moving to a care facility, with 44% of these residents having or indicating symptoms of depression. Social isolation is a contributor; 22-42% of these residents reported feeling severe loneliness. Video chat sessions have been found to be valuable augments to in-person visits. However, for adults with impairments such as dementia, operating the associated technologies might be impossible.

Predictive Analytics and Applications for Clinical Support in Orthopaedics

Nova Scotia is one of the oldest demographics in Canada, with increasing rates of total knee arthroplasty (TKA), yet the identification of high-risk surgical TKA candidates prior to surgery at a patient-level remains inconclusive, limiting our ability to improve care management. The objective of this research is to explore Nova Scotia’s rich and comprehensive research and clinical databases related to osteoarthritis and TKA, and identify linkages between patient-specific factors, treatment options, and health outcomes, through personalized medicine analytical modeling.

A fully customized image sensor for fluorescence imaging in biomedicine

Customized image sensors will be designed by EnviroSen specifically for advanced microscopes used in biomedical imaging. The goal is to develop image sensors with improved efficiency, image resolution and speed compared to existing technologies for novel microscopes for fluorescence lifetime imaging. The McMaster Biophotonics group has recently developed a novel microscope that is capable of detecting fluorescence lifetimes of biological samples with 400 times improvement in image acquisition speed.

Development and Validation of Software for the Three-dimensional Quantification and Visualization of Blood Flow Hemodynamics in Patients with Aortic Insufficiency using 4D flow MRI.

The most common cause of chronic aortic insufficiency (AI), a backwards leaking of blood through the aortic valve, are congenital valve disease, degenerative valve disease, and primary diseases of the surrounding aorta. Current management of severe AI is to surgically replace the valve based upon generic 2D imaging measures of severity and progression. However, 4D MRI flow has been recently introduced and may offer a paradigm shift in the ability to characterize AI, particularly due to different disease states.

Development of a simulation model for prediction of performance of an anesthesia circuit using a novel CO2 separation system

Anesthesia is delivered to patients in vapour form, supplied via Mechanical ventilation in closed loop anesthesia circuit. This necessitates the removal of the carbon dioxide (CO2) produced during respiration. Currently, anesthesia circuits use granulate-based CO2 absorbents that react with CO2 to remove it from the gas stream. However, anesthetic vapours also react with the chemical absorber producing toxic bi-products that have been connected to negative patient outcomes. DMF Medical Inc. has developed an early stage prototype device that provides an alternative method for CO2 removal.

Thermoplastic injection molding of bioprinter cartridges using silicon inserts

Patients who suffer from severe burns require immediate wound closure to ensure survival and facilitate healing. The current gold standard in surgical practice is the use of split-surface autographs, allographs, or skin substitutes, but limitation range from the lack of layered tissue organization, the potential for immunological rejection, and the need for high quantities of donated tissue.

Development of a simulation model for prediction of performance of an anesthesia circuit using a novel CO2 separation system

Anesthesia is delivered to patients in vapour form, supplied via Mechanical ventilation in closed loop anesthesia circuit. This necessitates the removal of the carbon dioxide (CO2) produced during respiration. Currently, anesthesia circuits use granulate-based CO2 absorbents that react with CO2 to remove it from the gas stream. However, anesthetic vapours also react with the chemical absorber producing toxic bi-products that have been connected to negative patient outcomes. DMF Medical Inc. has developed an early stage prototype device that provides an alternative method for CO2 removal.

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