Whole Genome Association Strategy for Unbiased Candidate Gene Selection in Inflammatory Diseases

Susceptible individuals for inflammatory diseases could be targeted for either preventative measures or care if we could identify them by obtaining their genetic code. However, to date, there is no effective method of discovering which of the more than 5 million genetic variants are important in determining disease susceptibility. A common approach is to test every genetic variation, in every patient, for its correlation with some disease (called Whole Genome Association orWGA), but this is extremely expensive and slow.

A New Decision-Support Tool for the Treatment of Patients Suffering from a Torn Anterior Cruciate Ligament

After a ligament injury to the knee, clinicians must decide on an optimal treatment for their patient. In most cases, they prescribe either conservative therapies (physiotherapy with or without orthotics) or surgery (which allows doctors to use two different grafts). The Centre du genou Emovi proposes a biomechanical assessment to better understand the functional status of the knee and to determine more accurately the appropriate treatment option.

Non-Viral Gene Delivery to Gut Stem Cells

The internship project will work to deliver a weight loss protein that will combat obesity. The intern will coat DNA for the protein with a natural substance that can be delivered orally or through surgery. If successful, the team expects to see the presence of this weight loss protein in the blood of the specimens. Moreover, the levels should increase after meals and this should encourage less eating and weight loss. enGene, a biotech company specializing in DNA delivery to the gut, will provide the training necessary for this project.

3D Rendering of Stress, Strain and Shear in TensegriCell Simulations of Cytoskeleton

Frantic Films, headquartered in Winnipeg, MB, has developed a reputation for creating innovative, custom built R&D solutions. The intern’s research project will straddle both the worlds of microbiology and physical simulation in order to create a dynamic, physically-based model of the cytoskeleton within a cell.

Precise Calculation of Brain Atrophy Due to Focal Lesions in MS Patients: Modification of Non-linear Registration Algorithm

NeuroRx is a Montreal, QC-based company which provides professional management of MRI-related study activities and delivers precise MRI outcome measurements that are performed in a regulatory compliant environment. This internship research project will involve image processing to quantify local volume changes in serial MR images of the brain based on deformation field analysis using techniques that are relatively independent of pathological changes in image intensity.