Dual inhibition of CA9 and CA12 as effective novel anti-cancer therapy

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect in 2D/3D systems and will move to preclinical/clinical trials upon successful in vitro validation.

Development of new approaches to promote proliferation of insulin producing pancreatic ?-cells in diabetic patients

Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic patients either by reducing ?-cell death or by increasing their proliferation is of great importance.

Transitioning from Print to Interactive Digital Publishing

PUBLIC is an innovative art journal published by Public Access exploring the intersection between art, technology and contemporary culture. This fellowship develops PUBLIC’s open access interactive web platform, PUBLIC:PORTAL, using information visualization and design to showcase the journal’s cutting-edge collaborative and cross-disciplinary work. Working with the Sensorium Centre for Digital Arts and Technology at York University, PUBLIC’s information designers, as well as Public Access’s network of artists and researchers, the fellow will develop the pilot issue of PUBLIC:PORTAL.

A systems biology approach to investigate chemoresistance in urothelial carcinoma of the bladder.

To perform a complete molecular analysis of muscle invasive bladder cancer (MIBC) before and after pre-operative chemotherapy to find changes responsible for resistance to treatment. Analysis will include a combination of DNA sequencing, RNA expression analysis and quantification of protein. Together this information will reveal the molecular landscape for these tumors.

Statistical Modeling of Infarct Growth in Acute Ischemic Stroke

Perfusion imaging with a CT scanner provides important information about blood flow and, in acute ischemic stroke, highlights regions of brain infarct, where tissue has died because of a lack of blood flow. This infarct region continues to grow over time until blood flow is restored. Being able to predict the rate of infarct growth would provide doctors with a key piece of information (currently unavailable) that would help them decide on a course of treatment.

Web-based Goal Management Training™ in older adults with cognitive impairment: a randomized-controlled trial examining feasibility and efficacy - Year two

As the Canadian population is aging, more and more Canadians will show cognitive decline. Aging and certain types of
neurological disorders is often associated with deficits in executive functions: goal maintenance, planning, task
switching and attention. These functions are critical for the maintenance of functional independence. Few validated
rehabilitation approaches for these types of deficits exist. One rehabilitation approach, Goal Management Training™
(GMT), has shown promise. In its standard implementation, GMT is led in small groups.

NGS-based estimation of quality of selective pre-amplification of bacterial RRN operon using Phi29

Rapid identification of bacteria in blood is important for the early identification of infection and emergence of resistance to therapy. There is no wishful, fast and simple, technological solution for this quest. Some of infections are life-threatening and requires fast and focused drug treatment as soon as possible. The present approach is to use empirical therapy and wait for culture results (if positive) to modify treatment, i.e. to remove unaffected drugs and add/increase drugs which will attenuate identified pathogen.

Development and validation of a tool for the measurement of hearing aid sound quality

Hearing aids are now fully digital, advanced signal processors. Studies show that the sound quality of today’s hearing aids is important, and may impact how a hearing aid user enjoys music. Few tools are available for clinicians to measure hearing aid sound quality in daily practice. In this project, we will develop and implement a tool for this purpose.

Deciphering the role of the tumor suppressor p53 in regulating treatment-induced ovarian cancer cell fate decisions in vivo

As the most lethal gynaecological cancer, ovarian cancers not only threaten lives of many women worldwide, but health side effects also burdens the life of millions patients following treatments. Novel therapeutic methods aiming at increasing the long-term survival of patients and decreasing health side effects associated with treatment is critical. We have already found that current chemotherapy protocols induce a very interesting phenomenon – cellular senescence - in treated cells. Senescence is thought to be beneficial in cancer therapy under certain conditions.

Assessment of Tissue Viability in the Lower Extremity of Diabetic Patients

In Canada, people with diabetes are 20x more likely to have an amputation of their lower limb than the general population. Having a diabetic foot ulcer (DFU) increases the risk of amputation by 50%. Early assessment and treatment of a patient’s DFU can prevent amputation, but patients with diabetes often lose sensation in their limbs, and may not even realize they have a DFU. There are currently no easily accessible early warning tools for DFUs. To address this need, we have invented a non-invasive device for DFU assessment, and are now optimizing it for use in patients at St.

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