A critical challenge today in neuro-surgery is the determination of tumor boundaries intraoperatively. There are means of doing this using high-resolution MRI machines, however, these can be prohibitively costly. Optical coherence tomography (OCT) offers a promising, cheaper, label-free alternative. However, the basic models used for clinical, real-time OCT limit its usefulness and depth of focus. This work will develop a type of image reconstruction that includes digital focusing and anisotropic properties.
Depression is a disabling condition affecting millions of people. Some of the symptoms of depression make it impossible for people to function in their daily lives. People experience significant levels of memory, thinking, planning and other cognitive symptoms that impair their abilities to go to work, school and take care of themselves and family. What is unclear is how and to what extent does this type of impairment lead to real world disability, and whether or not these levels of impairment exist in a broad range of people with varying levels of depressive symptomology.
Glioblastoma (GBM) is the most common primary adult brain tumor, characterized by extensive cellular and genetic heterogeneity. Even with surgery, standard chemotherapy, and radiation, tumor recurrence and patient relapse are inevitable with a median survival rate of
NATURE AND OBJECTIVES OF THE PROJECT
Patients who suffer from addiction to opioids often experience depression. Furthermore, data concerning the use of effective medication to treat depression in patients addicted to opioids is insufficient. Desvenlafaxine is an antidepressant that has been approved in Canada to treat depression within the general population.
Fibroproliferative disorders are a/the leading cause of morbidity and mortality worldwide. A large group of interstitial lung diseases (ILD) can cause progressive scarring of lung tissues, affecting the ability to breathe. Idiopathic Pulmonary Fibrosis (IPF) is one of the major forms of ILD and is characterized by a progressive decline in lung function. Although the pathogenesis of IPF is incompletely understood, work from our group and others suggest that transforming growth factor beta 1 (TGF-?1) is involved in the fibrogenic process.
The Think-Move-Play project's purpose is to study the feasibility and acceptability of utilizing smart insoles to collect health information and interact with patients suffering from hip fracture and neurological diseases. We propose a unique solution by combining personal health monitoring and coaching that is augmented with a virtual play environment aimed to maintain constant high level of motivation.
Allergic asthma is a condition of the airways characterized by airway constriction and hyperresponsiveness upon allergen exposure. About half of the allergic asthmatic individuals experience only an acute airway constriction (early response) within several minutes upon exposure to allergen while the other half of individuals experience not only an acute airway constriction but also a chronic airway constriction plus inflammation (late response) within several hours after the allergen exposure. It is not clear why the late response is not developed in all sensitized individuals.
The following document explores the impact of visual language and new gesture-based tools to create prototypes that can be used in the final stages of production. With the contemporary ample use of different prototyping tools to create iOS applications, the interaction between designers and programmers is evolving based on what these tools allow. Small cross-function teams observe a disconnection between what the designer initially animates with what the
developer programs at the end of the pipeline.
Inflammatory Bowel Disease (IBD) is thought to develop in people when their gut bacteria leak out of their intestines, and cause chronic gut inflammation. We recently found that the cells that line the guts of healthy people possess a specialized defense system called an inflammasome.
In preliminary studies, the inflammasome seems to prevent the gut from becoming leaky, and helps it fight bacteria. Interestingly, some people with IBD are known to be missing inflammasomes.
Recent discoveries show that neutrophils mainly die by formation of neutrophil extracellular traps (NETs) in Cystic Fibrosis airways. Therefore determining mechanism and identifying FDA-approved drugs that inhibit NETosis could provide novel options to treat CF lung disease. We aimed to do the comparative gene expression analysis during NETosis induced by different NET inducing agents (PMA,LPS,A23187) in CF neutrophils. Furthermore to translate the findings for therapeutic targets, screening of large scale drugs, kinases and specific pathways inhibitors associated with NETosis are required.