PDF - The anti-Helicobacter pylori properties of probiotic lactobacilli secretomes - ON-094
Preferred Disciplines: PDF, Microbiology & Immunology
Company: Lallemand Health Solutions
Project Length: 12 months
Desired start date: Fall 2017
Location: London, Ontario
No. of Positions: 1
Preferences: This work is seeking a PDF to work with Dr. Carole Cruezenet, Western University.
About the Company:
Supported by 80 years of history, Lallemand Health Solutions possesses strong expertise in the selection, development, production and marketing of probiotic strains and formulations that support human health and well-being.
Lallemand Health Solutions built a successful reputation in providing probiotic products with solid scientific research, a broad portfolio of regulatory assets, custom formulations and unique customer service to its partners, rapidly engraving its position as a major player in the probiotic category.
The position is for a post-doc to work with Dr. Carole Creuzenet (Western University, London Ontario) and Lallemand Health Solutions (Montreal, Quebec). The research will focus on anti-Helicobacter pylori effects of Lactobacill. This will include testing lactobacilli for their effect on viability of H. pylori, its production of virulence factors and its interactions with gastric cells and investigate the mechanism of action using sensor kinase mutants and transcriptomics analyses. It is based on strong preliminary data obtained in the Creuzenet lab in vitro and at Lallemand Health Solutions on commercial formulations.
While the PDF will be based mainly at Western where the bulk of sample preparation and testing will occur, the PDF will be expected to go work at Lallemand Health Solutions for at least 2 periods of 1-1.5 month each for transcriptomics and Illumina multiplexing work, or any other method required during the project. This work will provide an exciting joint academic and industrial research experience to the candidate.
The research will include testing lactobacilli for their effect on viability of H. pylori, its production of virulence factors and its interactions with gastric cells and investigate the mechanism of action using sensor kinase mutants and transcriptomics analyses.
The PDF will be expected to perform the experiments following established procedures initially, and to also develop improved procedures to enhance the throughput of the assays, for example using Flow Cytometry. The PDF will also be expected to help supervise an undergraduate student working jointly on this project.
Expertise and Skills Needed:
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