Statistical Modelling and Analysis of Complex Traits in Human Populations

Systematic Inflammatory Response Syndrome (SIRS) is an inflammatory response to a variety of severe clinical conditions such as infection, shock or trauma. An example of SIRS is sepsis, a systematic inflammatory response to infection. Sepsis is the most common diagnosis and cause of death among critically ill patients from intensive care units, occurring in about 1% of all hospitalized patients. SIRS is a complex genetic disorder involving a number of genes that act in conjunction with lifestyle and environmental factors to increase an individual's risk of developing the illness.