Identification of Blood Biomarkers for Diagnosis of Peripheral Arterial Disease

Fasting blood samples from persons with Peripheral Arterial Disease (PAD) and healthy individuals were previously collected during a prior Mitacs project.
A comparative analysis of the blood samples by metabolomics will be performed to identify potential biomarkers.
The intern will assist with the necessary correlation analysis for selecting compounds capable of serving as blood biomarkers for PAD.
Koven expects to directly benefit from the outcome(s) of this research by having the opportunity to commercialize any promising blood biomarker(s) into a diagnostic kit for early diagnosis of PAD.

Identification of Blood Biomarkers for Diagnosis of Peripheral Arterial Disease

Persons with Peripheral Arterial Disease (PAD) and healthy individuals will be recruited for a study to identify novel blood biomarkers for the diagnosis of PAD. Participants will be matched for age and sex. They will have their Ankle Brachial Index (ABI) and pulse wave velocity (PWV) measured. They will then be asked to return to the clinic within two days to provide a fasting blood sample. The intern will conduct a literature review regarding potential biomarkers for PAD diagnosis and become familiar with the diagnostic capabilities and equipment developed by Koven Technology Canada.