The analysis of protein-protein interactions is critical for understanding cell growth control, and how aberrant connections contribute
to cancer and other diseases. Mass spectrometry is a critical tool in this field, but sample complexity, instrument dynamic range and
resolution limit some applications. This project will evaluate the use of the SelexION ion mobility device and High Resolution TOF
with Zeno pulsing for enhanced separation and detection of cross-linked peptides from protein complexes and to detect posttranslational
modifications of proteins, specifically phosphorylation.
The bacterial transferrin receptor is considered to be a potentially efficacious candidate vaccine antigen against pathogens important in human disease and in animal husbandry. Previous data suggests that transferrin receptor-based antigens can elicit protection from both invasive disease and potentially from asymptomatic colonization. One major consideration when developing vaccines is the choice of adjuvant, a component able to influence the intensity, quality and breadth of the immune response.
The aim of the internship is for the intern to take up the challenge of detecting and removing noise from brain signals that are recorded using electroencephalogram (EEG). The noise that is of interest in the project is mainly caused by the subject chewing and walking. These noises are found to have caused the inability to have a high accuracy in performing seizure detection using EEG. Machine learning-based approaches are to be taken in the attempt to characterize these noises and subsequently eliminate it from the recorded brain signal.
Poor diet is one of the factors associated with obesity and overweight, which may increase the risk for chronic diseases such as diabetes, heart disease and cancer. Two ways to improve the diets at the population level are to 1) establish public health initiatives (e.g.
A critical challenge today in neuro-surgery is the determination of tumor boundaries intraoperatively. There are means of doing this using high-resolution MRI machines, however, these can be prohibitively costly. Optical coherence tomography (OCT) offers a promising, cheaper, label-free alternative. However, the basic models used for clinical, real-time OCT limit its usefulness and depth of focus. This work will develop a type of image reconstruction that includes digital focusing and anisotropic properties.
While torque is an important parameter in automotive performance, there are currently very few effective methods to monitor it in vehicles. The aim of this project is to develop a low-cost solution for real time engine torque monitoring. An autonomous sensor module will be developed and mounted to the flexplate connecting the engine and the transmission system in vehicles with wasted vibration energy in the flexplates being harnessed to power the sensor module.
Ventilator assisted individuals (VAIs) living at home are frail and generally cannot perform most daily activities. This is similarly the case for the palliative population of those with amyotrophic lateral sclerosis (ALS). Although these individuals prefer to live and die at home, the family members who care for them often experience stress and poor health. Peer support can mitigate health declines by decreasing caregivers isolation/stress and increasing their sense of control. However, no peer support programs are designed to meet these caregivers complex and unique needs.
"Poor efficacy and unpredictable toxic effects are leading causes of removal of a drug from the market. Many drugs act unpredictably in patients because they are tested in labs using cells grown in plastic dishes and animals that poorly mimic humans.
Administration of supplemental oxygen through medical air is a life-supporting measure essential for the management of severe primary respiratory conditions as well as secondary lung injury due to systemic insults such as trauma and sepsis. This medical air is often produced on site through devices which draw, compress and filter outside air in order to redirect it into buildings. However, depending on the outdoor conditions, the state of the ventilation system or the presence of microorganisms, this air can be contaminated.
Neisseria meningitidis (Nme) is a bacterial pathogen that often colonizes the upper respiratory tract of humans without symptoms, but which may also develop into rapidly-progressing sepsis and meningitis that can be fatal. Nme has evolved elegant means to specifically interact with human cells and proteins in order to colonize, survive and the evade host immune system. In partnership with Vaxiron Inc., we are developing a novel class of vaccines that target systems involved in Nme acquisition of the essential micronutrient, iron, during infection.