Impact of chronic exposure to vascular stressors on mitochondrial health and vascular smooth muscle cell plasticity

Blood vessels are made up of specialized cells including the endothelial cells lining the blood vessels and smooth muscle cells (SMCs) that constrict vessels and regulate blood flow. SMCs are constantly exposed to diverse growth factors, hormones and inflammatory signals that affect their phenotype and function. Mitochondria are essential to the normal functioning of SMCs, and aging and inflammation can effect mitochondrial number, structure and function.

Digital Pre-Distortion for Concurrent Multiband and Multiple Antenna Transmission

The proposed project aims at the design and implementation of low complexity digital pre-distortion (DPD) algorithms for multiband and multiple input multiple output (MIMO) wireless transmitters. The power amplifier (PA) is one of the major sources of power dissipation in wireless base stations. The DPD techniques enable the PA to operate in a more efficient power level resulting in more energy efficient wireless networks.

Combatting oil reservoir souring through a predictive understanding of the ecophysiologyand functional diversity of nitrate-reducing bacteria

Oil reservoir souring is the production of toxic hydrogen sulfide by sulfate-reducing microorganisms (SRM) through naerobic respiration supported by organic electron donors present in oil fields. In recent years, nitrate injection has merged as a promising green biotechnology that has been proven effective in controlling sulfide production in oil fields. This strategy relies on inducing nitrate-reducing bacteria (NRB), which can outcompete SRM for organic lectron donors.

Combined Building Integrated PV/Thermal (BIPV/T) Collector with Two-stageVariable Capacity Air Source Heat Pump for Net-Zero Energy Building Applications Year One

Building Integrated Photovoltaic/Thermal (BIPV/T) systems are arrays of photovoltaic panels integrated into the building envelope facades and roofs that produce electricity and incorporate the additional function of recovering useful thermal energy. The energy can be used for space, domestic water heating or air conditioning. Recuperating heat from the BIPVjT system improves electrical efficiency and reduces the temperature of PV modules resulting in extended life expectancy of the panels. BIPV/T systems also improve the aesthetic exterior appearance of the building.

Stochastic Control in Network Coding Enabled Wireless Systems Year One

Network stochastic control is considered as a primary goal in the design of emerging wireless networks. One of the objectives in the stochastic control of wireless networks is to enable crosslayer designs to achieve stochastically optimal resource allocation in the physical and MAC layers. Different stochastic performance criteria can be considered in the optimal control of wireless networks. Delay is one of the most challenging ones and has been addressed far less in the literature.

Aptamer-facilitated Virus Shielding (Apta?ViSh) Technology and Aptamer-facilitated AntivirusShielding (Apta-AntiviSh) Technology to extend the in vivo action of oncolytic viruses. Year One

This project aims to develop an aptamer-based technology to enhance the in-vivo survival of oncolytic viruses and thus the efficiency of virotherapy. Oncolytic viruses (OVs) can selectively replicate in tumor cells, leading to lysis of the tumor. OVs are particularly effective against metastatic cancers, which are especially difficult to treat conventionally. However, OVs can be deactivated by antiviral neutralizing antibodies (nAbs) and cleared from the circulation.

The impacts of omega-3 fatty acids on planktonic food web processes: anexperimental approach Year One

The causal link between highly unsaturated fatty acids (HUF As) and human health is one of the hottest topics in science. Their potential to control food web dynamics in freshwater systems is a relatively recent development, but analytical difficulties have relegated research to a predominantly theoretical nature. A large deal of theoretical work was produced from my doctoral research, and breakthroughs in measuring metabolic reactions permit the testing of multiple hypotheses produced.

Development of a smartphone-based sensor system to assess everyday movement, speech, and sleep for stroke recovery Year One

Following a stroke, the rehabilitation gains achieved in intensive therapy are often lost without sustained follow-up. The long-term objective of the project is to extend the reach of the health team (physicians, therapi sts, caregivers) following hospital discharge to continue therapy using mobile devices. As a first step, the objectives of the planned project are to:

1) develop clinically meaningful metrics related to the quantity and quality of everyday movement, speech, and sleep from body-worn sensor data,

2) to design and fabricate system prototypes for testing, and

Role of nocturnal fluid redistribution in the pathogenesis of sleep apnea Year One

when lying down to sleep and accumulates in the neck or lung; which could be a major contributor to the development of sleep apnea in HF patients. Therefore, we aim to determine whether: 1) the relative degree of fluid shift into the neck and lungs at night is associated with the severity of sleep apnea; 2) the respiratory sounds recorded from the neck and lungs can be used to estimate the amount of nocturnal fluid accumulated in the neck or lungs. If so, a new approach for the therapy of sleep apnea would be to prevent fluid accumulation in the legs during the day.

Development of an Electrodynamic Simulation Toolbox for Nanophotonics

Finite Difference Time Domain (FDTD) simulations allow researchers to model complex devices and systems based on integrated micro/nano structures. The electrodynamic behaviour predicted by FDTD simulations match very well with the real physical systems, which significantly accelerates the development of novel devices. However, there are limitations in existing FDTD techniques to model metal nanoparticles on sub-100 nm length- scales, which are of great interest to research and industry.

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