Regulation of T-type calcium channel activity by targeting channel trafficking – a novel approach for pain management Year two

Current therapies to manage pain either result in side effects or are insufficient and the associated medical costs and loss of work days come pose a tremendous socioeconomic burden. We recently showed that T-type channel activity is aberrantly regulated in inflammatory and neuropathic pain by the deubiquitinase USP5, and we have begun to explore this mechanism as a new therapeutic avenue based on interfering TAT peptides. We now plan to test our TATpeptides in diabetic neuropathy and inflammatory bowel pain.

Advanced Adaptivity and Personalization in Learning Systems through Collaborative Recommendations Year Two

Learning Systems are among the most popular e-learning tools in today’s education and training. Most e-Learning systems do not take into account individual aspects of learners (e.g., their goal, experiences, existing knowledge, learning style etc.).The primary goal of the  proposed research is to offer rich adaptivity by combining information from a learner’s profile (e.g. levels, goals, learning style, cognitive abilities etc) with the information from other learners sharing common interests.

Tests for models used in Actuarial and Risk management and Economic forecasting

In Actuarial Science and insurance, models are often used to assess risk using factors such as age, level of education, gender, environment, etc. In practice, there might be unobserved factors.  When data are gathered, the accuracy of these models should be investigated. If the model is not well fitted by the data, subsequent influences could be badly wrong. In this proposal, we shall examine tests to check the model validity. In addition, we examine the effect on inference of a failure in the model.

Radiochemistry for the Pharmacokinetic Evaluation of Novel Bone-Targeting Peptide Hormone Derivatives

This proposed research project is about development of new bone-targeting drug called PTHPEG- BP, this new compound will overcome shortages of current clinical peptide hormone PTH, and show better treatment efficacy and lower price then the latter; several new technologies will be used on research of this PTH, such as micro Positron Emission Tomography (PET/CT), and several of its characteristics will be identified such as structure, bioactivity, and metabolism inside body.

Evaluation of Application of Shredded Tiresas Insulation Layers for Highways in Alberta

Stockpiles of scrap tire grow larger every day in Alberta due to heavy industry. Safe and healthy disposal of scrap tires requires costly municipal landfill space. Using tire derived aggregates (TDA) for construction applications such as road embankment and insulation layers is of great attention and interest to Alberta’s government. Frost penetration beneath the pavement causing frost heave in winter followed by spring thaw weakening is one of the factors that affect the base layer thickness in cold climates.

Advanced Adaptivity and Personalization in Learning Systems through Collaborative Recommendations

Learning Systems are among the most popular e-learning tools in today’s education and training. Most e-Learning systems do not take into account individual aspects of learners (e.g., their goal, experiences, existing knowledge, learning style etc.).The primary goal of the  proposed research is to offer rich adaptivity by combining information from a learner’s profile (e.g. levels, goals, learning style, cognitive abilities etc) with the information from other learners sharing common interests.

Developing efficient computational simulationtools for geophysical applications

Quantitative interpretation of magnetic data through inversion for general distributions of magnetic susceptibility has played an increasingly important role in mineral exploration in recent years. The goal of the proposed project is to develop efficient and robust computational simulation tools for the inversion of magnetization at a specified depth using ground/airborne magnetic data.

Assessing the Effectiveness of Knewton's Adaptive Learning Technology

The goal of the project is to evaluate the pedagogical impact of Pearson’s Knewton-enhanced MyLab products in comparison to their regular MyLab products. Our focus will be on Knewton-enhanced MyMathLab and MyStatsLab. This project will deploy Knewton’s adaptive learning technology in our Data Analysis in Psychology course, a course dominated by second year students (approximately 90%). The course is a requirement for all Psychology students and offered every Fall semester. The assessment will occur in Fall 2013 and will provide data from over 300 students.

Visual Analytics for Financial Risk

The objective of this project is to design a Visual Systemic ‘Risk Map’ as one possible prototype to address some of the issues of risk identification and analysis in the context of global financial systems. We propose the design concept of the ‘Risk Map’ using principles of Cognitive Systems Engineering (instrumental papers in this field are Rasmussen et al. 1994; Vicente and Rasmussen, 1990; Woods and Roth, 1988), which is suited to engineering for complex systems.

Successful schools: Building a better measure of success

There are two interconnected processes required for this project to succeed: a process of consultation and engagement of the public and stakeholder groups, and the more technical development of measures. Both areas involve key methods for applied research and knowledge mobilization within the social sciences.

CONSULTATION AND ENGAGEMENT

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