Tumor engineering of biomaterial based cancer models for drug screening

The intern will use the company’s proprietary biomaterials to create tumors using cancer cells. These tumors can be used as an alternative to animal testing for cancer drugs. These cancer models will cost a fraction of the cost of animal models and can be tested using existing pharmaceutical techniques and equipment. The intern will develop a process to create tumors, then test existing drugs on the model to see how it compares to human and animal testing results.

Resisted sprinting and ischemic preconditioning as ergogenic aids in high-level sprinters

With a rise in talent and the number of youths participating in athletics, Canada has a seemingly bright future in track and field at the international level. With the abundance of talent, it is important to improve the resources available to our competitors to continue promoting excellence. We propose to study two novel protocols which can be performed immediately prior to competition in order to enhance performance. Resisted sprinting, which involves sprinting with a weighted sled or using a training device such as the 1080-Sprint is the first protocol under examination.

The use of inertial measurement units to quantify sport-specific movement patterns in elite sprint kayak athletes

Canoe kayak athletes use difficult body movements to move their boats at fast speeds. It has been hard to measure body movements that are needed to win paddling races in the past. Wearable devices are now able to measure athlete’s body movements when they are paddling. The goal of this research is to learn new ways to give athletes information about their movements so they can be better at their sport. The intern will learn how to use the wearable devices to help the athlete’s become faster paddlers.

Development of a Real Time Bioelectric BOD Sensor for Wastewater Effluent Compliance Monitoring

The necessity of cost-efficient and reliable wastewater treatment processes has increased in order to meet more stringent levels of environmental regulations, increased system reliability requirements and tightening operational budgets. To aid in meeting these operational goals, a strong market for low-cost, high-fidelity sensor technology that can relay real-time information to system operators on all aspects of wastewater treatment system performance has developed.

Immune modulation with checkpoint inhibitor antibodies targeting GITR or OX40 to improve cancer immune therapy with DepoVaxTM vaccine and metronomic cyclophosphamide

Immunovaccine Inc. is developing immune therapies for cancer using the company’s DepoVaxTM vaccine technology. DepoVax is a patented formulation provides controlled and prolonged exposure of antigens and adjuvants to the immune system, resulting in a strong, specific and sustained immune response. Immunovaccine’s translational research team is focused on improving responses in advanced cancers by combining DepoVax based vaccines with novel immune modulators in order to improve clinical trial design.

Development and proof-of-concept evaluation of 3D reconstruction molecular research tools

Traditional research microscopy tools are entirely adequate for conventional static analysis, however, the evaluation of more complex dynamic cellular processes require unconventional methods of acquiring, displaying, and rendering dynamic data. Autophagy occurs when some of a cell’s cytoplasm, referred as cargo, is enclosed by a membrane to form an autophagosome in order to be degraded and the products recycled. Autophagy is initiated to cope with stress, but we and others show that under non-stress conditions, specific cargos are targeted to the autophagosome.

Chromosome Engineering for Bioproducts from Methanotrophs - Year Two

Currently Metagenom Bio Inc. offers contract research services in environmental microbial species profiling. Applications for this service include the monitoring of biogas operations, greenhouses, and mining processes. Metagenom Bio wishes to offer solutions that use microbes to generate value-added products. Biogas reactors can break down waste products and produce methane, or natural gas. This methane can be burned, or some of it may be used to create materials using bacteria that can consume methane.

Identification of transcription factors involved in cannabinoid biosynthesis and glandular trichome formation - Year two

As an important medicinal plant, Cannabis sativa produces bioactive molecules that provide symptom relief for conditions such as severe cancer pain, nausea and vomiting associated with chemotherapy. The cannabinoid biosynthetic pathway that generates bioactive molecules has been studied for over a decade. However, understanding of transcriptional regulators that control cannabinoid synthesis is fairly limited. The primary site of cannabinoid biosynthesis is glandular trichomes that form on female flowers.

Establishing Physiological Norms for Brain Activity using Portable Electroencephalography

There is much about the brain we still do not understand. But, one fundamental way to understand how the brain works is to know normal range of activity. For example, how does your physician know that you have normal blood pressure? Similarly, why did the medical community choose “120 over 80”? The way we do that is to collect information from as many individuals as possible – thousands upon thousands! When you collect information from many people, scientists are able to paint a very clear picture of how blood pressure (or any variable of interest) varies across many people.

Versatile applications of a safe and efficient peptide in gene/drug delivery - Year Two

Gene therapy is one of the most attractive new therapeutic strategies in the treatment of multiple diseases. However, to apply gene therapy in clinic, an efficient and safe delivery system must be developed to transport these therapeutic reagents to target organs. The existing gene carriers suffer from either high cytotoxicity or immunogenicity problems, which will cause severe side effects when used in human. The new peptide based delivery system we developed demonstrated better performance and lower toxicity than the commercialized product on market.