Interaction of Cyclin-dependent kinase 2 with CR6-interacting factor 1, and the inhibitor search for such interaction against leukemia treatment resistance

Cyclin-dependent kinase-2 (CDK2) regulates cell cycle, whose structure and biological characteristics are well known. CRIF1 plays a regulatory role in the bone marrow microenvironment-induced leukemia cell cycle arrest through inhibiting CDK2. In this multi-disciplinary research, we will use a combined structure function study to reveal the interaction between CDK2 and CRIF1. This will facilitate the design of inhibitors for the interaction of the two important proteins, for eventual treatment of leukemia.

Longitudinal Weak Labeling for Lung Cancer Prognosis and Treatment Response Prediction

This project aims at evaluating whether recent results in deep learning models, trained to exploit weak labels (Hwang, 2016) can serve to extract meaningful lesion localizations from image-level labels, either from individual scans or given a (longitudinal) sequence thereof. To this end, we will scale up existing models that have been shown to work on 2D images to a 3D context, studying labeling performance as the dataset size grows.

Characterization of molecular pathways mediating the effects of novel therapeutic agents in heart failure

Heart failure (HF) is a condition that develops after the heart becomes damaged or weakened. HF occurs when the pumping action of the heart is not strong enough to move blood around, especially during increased activity or under stress. In addition, the heart muscle may not relax properly to accommodate the flow of blood back from the lungs to the heart. These abnormalities in heart function can cause fluid to back up in lungs and in other parts of body.

Development and validation of blood-based biomarkers for improved heart failure management

Chronic heart failure (HF) is an epidemic affecting approximately 1.5-2% of Canada’s population (12% in patients over 80yrs) and the current one-year mortality rate after HF diagnosis remains disturbingly high at 25-40%. Even with treatment, many HF patients require hospitalizations during the course of their disease; in Canada HF is responsible for $3 billion in hospital costs annually.

An Assessment of Local Business’ Understandings and Needs for Community Leadership in a Small Urban Setting

Community leadership development and training programs must respond to changing corporate and public perceptions. There has been a lack of research on community leadership within small urban settings, where the impact that training and development programs have may be high. Our objective is to describe how local businesses in a small urban setting understand community leadership and what needs they have with respect to training and development. We will conduct fifteen in-depth interviews with a diverse range of local business leaders in Greater Victoria, British Columbia.

Speech recognition for older, pathological voices

Some diseases and brain injuries can seriously impair language. Patterns in an individual's speech can allow computers to describe these impairment with a high degree of accuracy. These techniques can be used to test large groups of people for drug trials and potentially replace pen-and-paper based testing methods. To fully automate this process, speech recognition systems can be used to automatically transcribe speech. Unfortunately, these technologies continue to perform relatively poorly for elderly speakers, or for individuals with speech disorders.

Multi-user Training Software Development and Otoscope Tracking for Otolaryngology Education

Simulation is being used increasingly to improve medical education by providing students and trainees with greater access and opportunity to learn critical skills without affecting actual patient care. To this end, OtoSim has developed a multi-user training platform and an otoscope tracking device. The multi-user training platform allows the trainee to self-learn while being electronically connected to a central database for monitoring and advice.

Validation of novel neurofeedback training engine for improving brain health in aging and neurodevelopmental disorders

Memory impairment is the most common cognitive complaint among older adults. On the other side of the developmental spectrum, young adults that have been diagnosed with Autism Spectrum Disorders (ASD) have difficulty adapting flexibly to changing social circumstances. These memory and social deficits disrupt every day living. At present, promising interventions based on research using expensive and specialized equipment are reserved for clinical settings.

Analysis of protein interaction complexes by advanced mass spectrometry workflows

The analysis of protein-protein interactions is critical for understanding cell growth control, and how aberrant connections contribute
to cancer and other diseases. Mass spectrometry is a critical tool in this field, but sample complexity, instrument dynamic range and
resolution limit some applications. This project will evaluate the use of the SelexION ion mobility device and High Resolution TOF
with Zeno pulsing for enhanced separation and detection of cross-linked peptides from protein complexes and to detect posttranslational
modifications of proteins, specifically phosphorylation.

Optimization of the immune response against transferrin receptor based vaccines

The bacterial transferrin receptor is considered to be a potentially efficacious candidate vaccine antigen against pathogens important in human disease and in animal husbandry. Previous data suggests that transferrin receptor-based antigens can elicit protection from both invasive disease and potentially from asymptomatic colonization. One major consideration when developing vaccines is the choice of adjuvant, a component able to influence the intensity, quality and breadth of the immune response.