Transitional REM Sleep Brain Connectomes and Seizure Susceptibility

Seizures are rare while dreaming in rapid eye movement (REM) sleep. New research, however, suggests seizures may rebound during unstable REM sleep. This may be due to brain wiring (“connectivity”) since a highly connected brain is more prone to seizures, and connectivity changes from wakefulness to sleep. Brainwave tracings (“EEG”) can generate connectivity maps (“connectomes”) but adequate connectome resolution requires many EEG electrodes (“high density EEG”). This study uses high density EEG to examine brain connectomes and seizure susceptibility in unstable REM sleep.

Complex Continuing Care in a Rural Hospital: Optimizing community-based health care

Community hospitals in small towns or rural areas face challenges in delivering health care that will allow elderly members of their community to remain in the community that they helped to build. Using simulation modelling, this project will develop strategies for delivering complex continuing care in rural hospitals that is closely integrated with long-term care, residential care, and home care services. Small towns and rural communities have a tight-knit social fabric and the contributions that family support and community services provide to health care are important factors.

Development of a method using immuno-Raman for the simultaneous imaging of 15 biomarkers for immunotherapy of breast cancer.

We propose a novel approach that will provide researchers with an improved method to study multiple molecules, simultaneously in the same tissue section. Our strategy is to use novel nanoparticles that each emit unique multispectral signature and can be used simultaneously. We aim to develop a novel method to detect 15 breast cancer and immunotherapy-related biomarkers at the same time. The capability to detect a multitude of biomarkers simultaneously on the same tissue section would provide unprecedented headways in the field of cancer research and particularly on tumor profiling.

Understanding changes in corticospinal excitability due to chronic resistance training and fatigue

The proposed research will allow us to determine how the human central nervous system (i.e. brain and spinal cord) functions to produce different intensities of muscle contractions with and without fatigue. We will use a variety of stimulation technics to determine how active the brain and spinal cord are during the arm contractions. We do not currently have a detailed understanding of how the brain and spinal work together during force production.

The Impact of Renovations in Long Term Care Living Spaces on Residents with Dementia, their Families and the Staff that Care for Them

Riverview Health Centre (RHC) plans to renovate their special care units and grounds, which accommodate 60 residents with intermediate and advanced stages of dementia. The main purpose of this study is to examine the effects of the renovations on residents, family and staff using a multi-methods research approach and a multi-disciplinary team of researchers (i.e., architecture, sociology, kinesiology, clinical psychology, pharmacy, nutrition, nursing, and health sciences).

Towards personalized surgical spine reconstruction post tumour resection

We aim to develop tools to assess patient outcomes following treatment and removal of bone metastases. We will identify markers for enhanced patient outcomes, so as to predict which patients may benefit from more aggressive treatments to better their quality of life. We also aim to use 3D printed bone implants to help in the treatment of patients with bone metastasis. These implants will serve as a local reservoir for the anticancer drugs that will improve bone regeneration while also preventing tumor recurrence.

Towards Detection of Subclinical Joint Bleeds in Hemophiliacs: Advanced Imaging

This project aims to assess how the use of the novel “ultra-short echo-time” (UTE) MR imaging technology can “add value to” conventional MRI for detection and quantification of blood products in hemophilic joints. We will test this novel technology in joints of hemophilic patients with different stages of arthropathy presenting with blood products at different stages of degradation as compared with existing MRI sequences.

Pelvic Floor Health and Sexual Well-Being in Men

The promotion and maintenance of men’s pelvic floor health is a growing concern as pelvic disorders affect a substantial number of men and their prevalence is expected to increase as a result of Canada’s aging population. Pelvic floor disorders go beyond their physical consequences as they can negatively impact men’s psychological, sexual, and social quality of life. Evidence strongly suggests pelvic floor muscle training can contribute to the promotion and maintenance of pelvic floor health and to the treatment of symptoms associated to pelvic floor disorders.

Concussion Diagnosis: Improving clinical decision making in football

Diagnosing and managing concussions have become an increasing priority in sports medicine. The King-Devick test is a screening assessment of neurological functioning detecting impaired eye movements and saccades. During the 2016 Canadian Football League (CFL) season, all players will undergo pre-season (baseline) and post-injury testing with the King-Devick test in addition to the CFL’s standardized medical evaluation for concussion. This project will conduct a sensitivity and specificity analysis of the King-Devick test to evaluate its effectiveness in diagnosis concussions.

Preparation of a new formulation to prevent surgical adhesions

Inter-tissue adhesions cause significant complications following veterinary surgery of domesticated animals. Fucoidans are natural, negatively charged, carbohydrate polymers (polysaccharides) from seaweeds that have been successfully developed and commercialized for reducing such adhesions, thereby improving surgical outcomes. Currently, the inherent variability in the molecular size and composition of native fucoidans extracted from seaweed presents a significant barrier for their break-through application in human surgery.