Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases - Year Two

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes.

Looking at the Physical and Psychosocial Outcomes of an After-School Physical Activity Intervention for Children with Congenital Heart Disease

The research intern will be working with Sportball to offer one of their multi-sport after-school programs to children who are living with serious heart defects. Physical activity has many health benefits for children, and after-school programs are an effective way to increase daily physical activity levels. Children living with heart disease are a vulnerable group who don’t regularly participate in physical activity, putting them at risk of developing chronic diseases later in life.

Evaluating the prospective benefits of physical demands description (PDD) data created from job simulations

Every job at Ford Motor Company should have an associated document describing the physical demands (i.e., lifting, climbing, pushing, etc.) required in that job. This information is important to select job candidates with the right blend of capabilities to be able to safely meet these demands. Perhaps more importantly, this information also provides a benchmark to guide health care providers in helping injured workers rehabilitate their capabilities so that they can again return to their job, safely meeting the job’s demands.

Mevalonate Cascade Inhibition Sensitizes human Glioblastoma Cells to Temozolomide via Modulation of Autophagy

Glioblastoma multiforme (GBM), also known as glioblastoma and grade IV astrocytoma, is the most common and most aggressive cancer that begins within the brain. There is no clear way to prevent the disease. Typically treatment involves surgery after which chemotherapy and radiation therapy is used. The medication Temozolomide (TMZ) is frequently used as part of chemotherapy. Cholesterol lowering drugs (statins) is recently being considered as a novel and safe approach for combination therapies in many cancers.

Enteroids and enteroid derived monolayer cultures: Using primary intestinal epithelial cell cultures to define the mechanisms underlying epithelial intrinsic innate defenses

Using growth media available from Stemcell technologies, along with our own tools and techniques, we can isolate and grow intestinal stem cells from mice or human patient donors into enteroid cultures. Enteroids are 3D cell cultures that replicate many of the structures and types of cells found in the intestinal lining. We propose to work with Stemcell technologies to continue to develop their growth media for enteroid culture and apply these new media and techniques to further or understanding of how these cells help the body defend against infection.

Technology to improve walking competency in seniors

Walking pattern in healthy adults changes with age. A poor walking pattern results in fall and fear of falls. It is important to detect early changes in gait so that corrective measures are taken. In this project I am planning to use a sensor (Heel2Toe device) that detects when an individual makes a correct step while walking. In addition, the proposed device will also give a sound feedback when person makes a correct step. This device will be used by the therapist to understand gait deviations as well as prescribe this device to use at home for training.

Mitigating the risks associated with radio-frequency cardiac ablation

A cardiac arrhythmia is defined as an abnormal heartbeat which happens when the patient’s heart beats too fast, too slow, or in other irregular patterns. Although arrhythmia can occur without any symptoms, it is typically associated with heart palpitations, chest pains, fainting or heart failure. One type of treatment option is an interventional catheter-based procedure, which involves a technique called cardiac ablation. In such procedures, a catheter is advanced from the groin area into the heart.

Improving signal processing in hearing aids to support music and emotional speech

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing aids restore the intelligibility but not the emotional content of speech, which is carried by acoustic cues that are similar to salient dimensions of music.

Design of an Interface for the Intuitive Control of a Unmanned Air Vehicle fleet in Emergency Situations

The project consist of developing a novel interface to control a fleet of quadcopters in an emergency situation. The interactive system will have to interpret the user intent in such a way that minimum cognitive resources are required. Humanitas products target non experts in robotics whom need to maximize their concentration on medical support and logistic, thus they require an intuitive and not monopolizing control interface. It will also be required that feedback information can be sent to the user without using the visual feedback of their application control screen.

The Semaphorins, a role Inflammatory Bowel Diseases

Inflammatory bowel disease (IBD) includes both Crohn’s disease (CD), and ulcerative colitis (UC). Approximately 230,000 Canadians are affected by these diseases and they have important repercussions on quality of life and on both personal and societal direct and indirect costs. The cause(s) are poorly understood, and treatment is largely symptom-based and not curative. Commonly used drugs may have potentially important adverse effects such as cancer and serious infections. Moreover, some patients are resistant to these drugs. Therefore, safer and more efficient therapies are needed.