Signal Parameter Estimation and Tracking During Atrial Fibrillation Using a Bayesian Time-Delay Estimator

AF is an irregular heart rhythm resulting from abnormal electrical impulses and is the most common cardiac arrhythmia encountered in clinical practice. Ablation therapy has been used to eliminate areas responsible for maintaining the arrhythmia using radiofrequency energy. Targeting the culprit regions usually require accurate estimation of activation times in IEGM recordings. The conventional time domain methods fail to present a precise activation detection method and depend on parameters set by an operator.

Assessment of the Neonatal Lung Using Structural and Functional MRI

Currently available diagnostic imaging tools, such as chest radiography and computed tomography, are inadequate for assessing the lungs of preterm neonates. There is considerable interest in using magnetic resonance imaging (MRI) to monitor lung development in neonates longitudinally, since it is a non-invasive and non-ionizing imaging modality. MRI can potentially detect complications at an early stage and improve outcomes by monitoring the effectiveness of therapy, however, images typically suffer from poor signal and organ motion.

Examining the effects of “Fearless Physical Activity” workshops on physiological and psychosocial health in children with congenital heart disease

The “Fearless Physical Activity” workshops are designed to educate and introduce children with congenital heart disease (CHD) to physical activities that are safe for their health. These workshops will provide opportunities for children with CHD and their families to try new activities and to learn about the benefits of lifelong physical activity, specific to those with CHD. The research project undertaken by the intern will look at the effect of these workshops on daily physical activity, physical activity motivation and self-esteem.

Feasibility Evaluation Study of LifeguardMobile (designed for supported self-management of patients with chronic and complex conditions) - Year two

"Lifeguard Health Networks Inc. (LHN) has developed a secure Virtual Health Assistant application (app), to enhance supported self-management for patients with chronic and complex conditions, by leveraging their network of trusted family and friends, under the direction and guidance of health practitioners.We are conducting a study to evaluate the feasibility of the app and the level of user engagement with this form of supported self-management. This is a non-randomized, interventional study having both objective and self-reported outcome measures.

Assessment of biomarkers for the non-invasive diagnosis of male infertility

Infertility is a health issue that affects over half a million Canadian of childbearing age. Half of these cases are related to male reproductive dysfunctions. While semen analysis provides information about some causes of male infertility, about thirty percent of these cases remains unexplained. In this context, the main goal of our project is to assess the potential of target molecules, which are secreted from the internal organs of the male reproductive system into the seminal plasma, as biomarkers for the non-invasive diagnosis of infertility.

Raman micro-spectroscopy for biopsy for prostate cancer prognosis -Year two

Prostate biopsies can be difficult to interpret using standard pathology techniques. Because cancer can be fatal, the development of technologies providing complementary information could improve current pathology practice resulting in improved patient outcome. Raman micro-spectroscopy is a molecular imaging technique using backscattered light following tissue laser excitation to indicate whether or not prostate samples contain cancer cells. However, this technique is very sensitive to the molecules in chemicals used to process tissue (e.g. paraffin), which greatly limits its efficacy.

Novel Cell-surface Engineering Methods to Increase Immune-tolerance of Allogenic Cell Transplantation

Blood transfusion is required for surgery, for the treatment of traumatic accidents and for patients with disorders that require lifelong transfusion therapy. However, when patients receive “mismatched” blood transfusion, their immune system will attack and destroy red blood cells with surface sugars and proteins that differ from their own. This results in massive immune responses in patients, causing shock and even death.

An Integrated Mobile Communication Environment for Healthcare Professionals and Patients: Analysis, Prediction and Recommendation

Think Tank Innovations Ltd is a company active in the healthcare domain. The company is interested in expanding their current working system Sharesmart application by benefiting from advanced technology to develop an integrated environment for healthcare solutions in order to better service a wider community locally and globally. Students to be involved in this project will build a data repository to host data to be collected, cleaned, built, integrated and processed for knowledge discovery which will guide more focused decision making.

Effects of various compounds on central nervous system neurons as potential therapeutics against epilepsy

Xenon has developed isoform selective blockers of the sodium channels that are expressed in CNS neurons with the intent of developing them for therapeutic use, especially epilepsy. The primary goal of this research project is to determine the activity of compounds on CNS neurons. Until now, all characterization has been done with heterologously expressed channels. Until recently, a major impediment to such studies is the heterogenous nature of CNS neurons, so that a large number of studies need to be conducted for a complete characterization.

The effects of X-Act Compression garments technology on muscle fatigue, active and passive joint torque and performance

There are many compression garment products on the market claiming to improve some aspect of performance, however their claims are not validated with empirical data. In fact, current literature regarding the benefits of compression garments on cardiovascular and biomechanical performance is controversial; with many results suggesting non-significant or even negative effects provided by the compression garment.