Co-registration of Nuclear Medicine Images with Anatomical Images for Attenuation Correction and Localization of Activity

Medical image registration is the task of bringing two images into spatial alignment. Automatic and accurate 3D co-registration of nuclear medicine 3D image data with 3D anatomical data is crucial for improving the functional image reconstruction through anatomy-based attenuation correction. Co-registration is also important for the fusion of anatomical data with functional information. Most registration methods involve optimizing an intensity-based similarity metric that is defined by the transformation parameters.