Ventilator assisted individuals (VAIs) living at home are frail and generally cannot perform most daily activities. This is similarly the case for the palliative population of those with amyotrophic lateral sclerosis (ALS). Although these individuals prefer to live and die at home, the family members who care for them often experience stress and poor health. Peer support can mitigate health declines by decreasing caregivers isolation/stress and increasing their sense of control. However, no peer support programs are designed to meet these caregivers complex and unique needs.
Administration of supplemental oxygen through medical air is a life-supporting measure essential for the management of severe primary respiratory conditions as well as secondary lung injury due to systemic insults such as trauma and sepsis. This medical air is often produced on site through devices which draw, compress and filter outside air in order to redirect it into buildings. However, depending on the outdoor conditions, the state of the ventilation system or the presence of microorganisms, this air can be contaminated.
Neisseria meningitidis (Nme) is a bacterial pathogen that often colonizes the upper respiratory tract of humans without symptoms, but which may also develop into rapidly-progressing sepsis and meningitis that can be fatal. Nme has evolved elegant means to specifically interact with human cells and proteins in order to colonize, survive and the evade host immune system. In partnership with Vaxiron Inc., we are developing a novel class of vaccines that target systems involved in Nme acquisition of the essential micronutrient, iron, during infection.
Fibroproliferative disorders are the leading cause of morbidity and mortality worldwide. A large group of interstitial lung diseases (ILD) can cause progressive scarring of lung tissues, affecting the ability to breathe. Idiopathic Pulmonary Fibrosis (IPF) is one of the major forms of ILD and is characterized by a progressive decline in lung function. Although the pathogenesis of IPF is not completely understood, work from our group and others suggest that transforming growth factor beta 1 (TGF-?1) is involved in the fibrogenic process.
Seizures are rare while dreaming in rapid eye movement (REM) sleep. New research, however, suggests seizures may rebound during unstable REM sleep. This may be due to brain wiring (connectivity) since a highly connected brain is more prone to seizures, and connectivity changes from wakefulness to sleep. Brainwave tracings (EEG) can generate connectivity maps (connectomes) but adequate connectome resolution requires many EEG electrodes (high density EEG). This study uses high density EEG to examine brain connectomes and seizure susceptibility in unstable REM sleep.
Community hospitals in small towns or rural areas face challenges in delivering health care that will allow elderly members of their community to remain in the community that they helped to build. Using simulation modelling, this project will develop strategies for delivering complex continuing care in rural hospitals that is closely integrated with long-term care, residential care, and home care services. Small towns and rural communities have a tight-knit social fabric and the contributions that family support and community services provide to health care are important factors.
We propose a novel approach that will provide researchers with an improved method to study multiple molecules, simultaneously in the same tissue section. Our strategy is to use novel nanoparticles that each emit unique multispectral signature and can be used simultaneously. We aim to develop a novel method to detect 15 breast cancer and immunotherapy-related biomarkers at the same time. The capability to detect a multitude of biomarkers simultaneously on the same tissue section would provide unprecedented headways in the field of cancer research and particularly on tumor profiling.
The proposed research will allow us to determine how the human central nervous system (i.e. brain and spinal cord) functions to produce different intensities of muscle contractions with and without fatigue. We will use a variety of stimulation technics to determine how active the brain and spinal cord are during the arm contractions. We do not currently have a detailed understanding of how the brain and spinal work together during force production.
Riverview Health Centre (RHC) plans to renovate their special care units and grounds, which accommodate 60 residents with intermediate and advanced stages of dementia. The main purpose of this study is to examine the effects of the renovations on residents, family and staff using a multi-methods research approach and a multi-disciplinary team of researchers (i.e., architecture, sociology, kinesiology, clinical psychology, pharmacy, nutrition, nursing, and health sciences).
We aim to develop tools to assess patient outcomes following treatment and removal of bone metastases. We will identify markers for enhanced patient outcomes, so as to predict which patients may benefit from more aggressive treatments to better their quality of life. We also aim to use 3D printed bone implants to help in the treatment of patients with bone metastasis. These implants will serve as a local reservoir for the anticancer drugs that will improve bone regeneration while also preventing tumor recurrence.