Investigating the feasibility of a sensor-based hip protector for automatically detecting falls and characterizing activities of daily living in frail older adults

Over 350,000 Canadians live in long-term care facilities where the rate of falls is up to 3 times higher than among individuals living in the community. Wearable sensor technology holds great promise to accurately monitor an individual’s fall risk based on the activity profile and to detect dangerous fall events. With the understanding that hip protectors are commonly used in this population the objective of this project is to investigate the feasibility of a sensor-based hip protector to accurately detect falls and monitor daily activities.

Diagnostic Screening for Conscious Awareness in Brain Injury and Disease: Developing the Visual Component

Presently medical personnel do not have adequate tools to assess disorders of conscious awareness after severe brain injury if the patients have difficulty speaking & moving. These people are frequently deemed unresponsive when they may be “in there" but unable to respond. Our research team has developed a rapidly administerable, portable system that measures brain waves in response to sounds & spoken sentences. Once diagnosis has been established, personnel are more equipped to make decisions regarding a patient's candidacy for rehabilitation.

Impact of a pharmacist-led therapeutic nutritional intervention on medications and glucose control in type 2 diabetes

In this project, community pharmacists will help patients with type 2 diabetes to make dietary changes to reduce their consumption of carbohydrates while lowering or eliminating their need for costly diabetes medications. The results will help inform pharmacy practice and diabetes management and represent a novel treatment strategy placing pharmacists as key integrators of lifestyle and medication care for patients with type 2 diabetes.

The effects of unilateral dominant knee extensors fatigue on non-exercised contralateral and ipsilateral elbow flexors

The aim of this study is to further quantify the global effects of NLMF. To the best of our knowledge, this is the first study of it's kind to examine NLMF in muscle groups of both the upper and lower body which are ipsilateral to the fatigued muscle group.

Using systems engineering as a framework to evaluate a Pre-residency program for international medical graduates

Evaluation is a key element to assure the high quality of programs. The Pre-Residency program is meant to prepare the international medical graduates to be at the same level as any locally trained Medical graduate in Canada for their specialty training rotations. In this project we are using an innovative engineering approach to conduct an evaluation of the Pre-Residency program. Our goal is to provide a more objective evaluation using engineering to help assure the high quality of the Pre-Residency training program offered by the Touchstone Institute.

Design and validation of a novel peptide immunotherapeutic for the treatment of dog allergies - Year two

Adiga Life Sciences Inc. developed a novel immunotherapeutic platform in which small components (peptides) of allergen proteins are identified and administered in a regimen that causes immune cells to become non-responsive towards the allergens. In a phase II clinical trial, the cat allergy treatment developed by Adiga using this platform reduced allergic symptoms in allergic subjects. However, the mechanism of action of the peptide treatment is still not fully understood.

Visualization of TBI Multimodal Brain Imaging Data

The increased incidence of traumatic brain injury (TBI) and its potentially serious long-term consequences have enormous clinical, societal and economic impacts in Canada. Yet despite its relatively high prevalence, TBI is one of the least understood neurological injuries. Emerging evidence shows that the effects of TBI are not transient and may be associated with significant long-term consequences on brain function. An impact to the head results in an immediate and direct insult to the brain, setting off a complex cascade of metabolic and neurochemical events.

Development of new methods for metabolomic screens

In this project we aim to generate simple assays similar to commercial pregnancy tests that can detect the presence of specific molecules (metabolites) related to disease conditions. We will use our knowledge and
experience to generate easy-to-use strips that will allow specific detection of health-relevant metabolites that can be used in clinical or at-home settings by patients and physicians; providing for the rapid submission and
analysis of results.

Building Capacity in Health Care Providers to Effectively Communicate Health Risk Information related to HIV with Clients and Patients. Phases 2 and 3

The aim of The Ontario HIV Treatment Network (OHTN) is to help combat the spread of HIV by supporting, conducting, and sharing the best research possible. This project will involve a novel analysis of previously conducted focus groups with front-line service providers to help determine the factors that most influence the perception of HIV risk.

Probiotics Alleviating Depressive Symptoms (PADS)

Recent evidence shows there is extensive and direct communication between the brain and gastrointestinal tract, where nutrients are absorbed, and that intestinal microbiota have a role in healthy brain function. This study aims to look at the effects of probiotics, live bacteria that inhabit the gut and can help improve your health, on the mood, cognition, and sleep of depressed patients.

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