Using multivariate deep-learning algorithms for automatic quality control of high-resolution MRI

NeuroRx is an imaging contract research organization (CRO) specialized in the central nervous system (CNS). This company utilizes state-of-the-art digital image processing techniques to produce accurate and precise outcome measures for clinical trials of drugs in development. Prior to analysis, all scans must pass Quality Control (QC). The goal of my project is to incorporate advanced computer algorithms to automatically classify the quality of high-resolution structural brain Magnetic Resonance Images. The advanced computer algorithms will include deep learning algorithms.

Validation of Quality of Life Instruments for acne involving face and torso; and for hidradenitis suppurativa

The goal of this project is to provide evidence of validity for two newly developed measures of quality of life; one for hidradenitis suppurativa (HS) and one for acne. Both HS and acne negatively impact quality of life; however, to date, there are no disease-specific, patient-centered quality of life measures. The results of this project will provide healthcare professionals with tools to assess the impact of these conditions and their treatments (HS and acne) on patients’ quality of life.

Appropriate Neuromuscular Rolling Intensities and Applications

Prior research has shown that rolling muscles can increase flexibility without performance decreases. These studies have used a variety of rolling pressures (intensities). It is not known whether higher or lower rolling pressures are better for improving flexibility. Thus one of the studies will examine different pressures of rolling on flexibility and muscle performance. On the other hand, it is not known whether the rolling effects are improved when combined with stretching. It is also not known what the duration of these effects might be.

Vital signs monitoring at home using the pulse oximeter utilizing analog sensors on a mobile device

The research project will develop key algorithms that enable pulse oximetry, on a smartphone, to be used effectively as a device for monitoring the function of heart and respiratory system at home. LGTmedical has developed a pulse oximeter that utilizes inexpensive clinical sensors driven by software running on a smartphone, sending the driving signals through the audio port. This technology already operates with clinical accuracy for uses in spot-check monitoring of blood oxygen and heart rate.

Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases - Year Two

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes.

Looking at the Physical and Psychosocial Outcomes of an After-School Physical Activity Intervention for Children with Congenital Heart Disease

The research intern will be working with Sportball to offer one of their multi-sport after-school programs to children who are living with serious heart defects. Physical activity has many health benefits for children, and after-school programs are an effective way to increase daily physical activity levels. Children living with heart disease are a vulnerable group who don’t regularly participate in physical activity, putting them at risk of developing chronic diseases later in life.

Evaluating the prospective benefits of physical demands description (PDD) data created from job simulations

Every job at Ford Motor Company should have an associated document describing the physical demands (i.e., lifting, climbing, pushing, etc.) required in that job. This information is important to select job candidates with the right blend of capabilities to be able to safely meet these demands. Perhaps more importantly, this information also provides a benchmark to guide health care providers in helping injured workers rehabilitate their capabilities so that they can again return to their job, safely meeting the job’s demands.

Mevalonate Cascade Inhibition Sensitizes human Glioblastoma Cells to Temozolomide via Modulation of Autophagy

Glioblastoma multiforme (GBM), also known as glioblastoma and grade IV astrocytoma, is the most common and most aggressive cancer that begins within the brain. There is no clear way to prevent the disease. Typically treatment involves surgery after which chemotherapy and radiation therapy is used. The medication Temozolomide (TMZ) is frequently used as part of chemotherapy. Cholesterol lowering drugs (statins) is recently being considered as a novel and safe approach for combination therapies in many cancers.

Enteroids and enteroid derived monolayer cultures: Using primary intestinal epithelial cell cultures to define the mechanisms underlying epithelial intrinsic innate defenses

Using growth media available from Stemcell technologies, along with our own tools and techniques, we can isolate and grow intestinal stem cells from mice or human patient donors into enteroid cultures. Enteroids are 3D cell cultures that replicate many of the structures and types of cells found in the intestinal lining. We propose to work with Stemcell technologies to continue to develop their growth media for enteroid culture and apply these new media and techniques to further or understanding of how these cells help the body defend against infection.

Technology to improve walking competency in seniors

Walking pattern in healthy adults changes with age. A poor walking pattern results in fall and fear of falls. It is important to detect early changes in gait so that corrective measures are taken. In this project I am planning to use a sensor (Heel2Toe device) that detects when an individual makes a correct step while walking. In addition, the proposed device will also give a sound feedback when person makes a correct step. This device will be used by the therapist to understand gait deviations as well as prescribe this device to use at home for training.