Evaluation Capacity Network: Aligning Evaluative Thinking and Practice among Early Childhood Stakeholders

This project aims to provide much needed evidence to non-profit organizations working with vulnerable children and their families in five inner city schools. The All in for Youth initiative is a collaboration of eight organizations offering integrated, multi-dimensional supports to improve academic outcomes and resiliency of vulnerable children, support family health and stability, get communities involved, and inform policy and systems change.

Improving implementation of the intensive lifestyle intervention and accuracy of lifestyle data collection in the REMIT-Dapa trial.

Type 2 diabetes (T2D) results in high blood sugars and can cause serious complications. Recent studies suggest that treatment with diabetes medications along with lifestyle changes can result in patients not needing diabetes medications for months or even years, a concept known as diabetes remission. The Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT) pilot trial was done to look at the effect of lifestyle changes and diabetes medications in people with T2D.

Improving decision-making by reducing anxiety

Performance anxiety has been shown to negatively impact decision-making as well as academic performance, but it is unclear whether the effect of anxiety on test performance is due to impaired decision-making. Audio-Visual Entrainment (AVE), which involves exposure to rhythmically pulsating light and sound, has been shown to relieve anxiety symptoms — thus, AVE may be able to improve decision-making by alleviating anxiety, which may translate to better academic test scores.

A study on the reliability of quantitative measures of the visual system and their correlation with change in concussion-associated symptoms

This project will determine if abnormal behavior of the visual system correlates with symptoms in patients with concussions. Our first step will be to ensure that we obtain the same values for each of 7 tests when we measure a healthy person twice within a short period of time (called reliability). Next, we will see the how changes in the seven different measures of the visual system over time correlate with changes in patients’ post-concussion symptoms over time.

Blood flow within microfluidic conduits

A current area of focus at SMT Americas is to develop injection-moulding methods for medical lab-on-chip (LOC) devices, particularly to transport and process blood and plasma while eliminating conduits clogging and reducing sample loss. This project will evaluate the effect of flow conditions on viscosity of samples, and the adequacy of conduit structures achieved with SMT Americas’ technology for cell separation.

Real Time Inverse Scattering for Optical Coherence Tomography

A critical challenge today in neuro-surgery is the determination of tumor boundaries intraoperatively. There are means of doing this using high-resolution MRI machines, however, these can be prohibitively costly. Optical coherence tomography (OCT) offers a promising, cheaper, label-free alternative. However, the basic models used for clinical, real-time OCT limit its usefulness and depth of focus. This work will develop a type of image reconstruction that includes digital focusing and anisotropic properties.

Investigation of impact of technological advancement in positional MRI on measuring cerebrovascular reactivity

With the advancement of magnetic resonance imaging (MRI) techniques, an exciting time has emerged for research in the field of cerebral anatomy and physiology. The basis of this proposal is to employ a one of a kind imaging technique to drive forward our basic understanding of regional blood flow regulation in the human brain. The circulation of brain blood flow is profoundly influenced by the local prevailing pH (acid-base balance).

Cognitive Impairment Secondary to Depressive Symptomology and its Relationship with Functional Impairment

Depression is a disabling condition affecting millions of people. Some of the symptoms of depression make it impossible for people to function in their daily lives. People experience significant levels of memory, thinking, planning and other cognitive symptoms that impair their abilities to go to work, school and take care of themselves and family. What is unclear is how and to what extent does this type of impairment lead to real world disability, and whether or not these levels of impairment exist in a broad range of people with varying levels of depressive symptomology.

Understanding and Reducing Community-Based Personal Support Workers’ Risk of Occupational Injury

Personal Support Workers (PSWs) provide 70-80% of all paid home care. Unfortunately, community-based PSWs experience occupational injuries at more than twice the rate of the general population.

Budget impact analysis of Rapid Endovascular Treatment of Ischemic Stroke

The return on investment for medical imaging, interventional radiology, is not well understood, with limited existing research on the value realised from the funds spent. It is expected that the Hot Stroke Intervention by interventional radiologists will not only add direct value to the health care system but will have far reaching and significant impact on the Canadian economy. According to the Canadian Heart & Stroke, an estimated 62,000 strokes occur in Canada each year – one every nine minutes. More than 400,000 Canadians are living with long-term disability from stroke.