iMALDI-based Assays for Protein Activity to Improve Patient Selection for Therapeutic Akt Inhibitors in Cancer Treatment

Detailed profiling with modern analytical technologies has shown that most cancer types are composed of multiple small sub-populations with distinct molecular signatures. Correct identification of the cancer subtype can predict its response to a particular treatment. Genomics has commonly been applied for this purpose, but in some cases, our ability to predict drug response may be enhanced by instead measuring the drug’s direct protein target.

Investigation and development of plasma-based cancer diagnostic

The blood of cancer patients contains DNA that has been shed by their tumours (circulating tumour DNA or ctDNA). As such, any genetic mutations in the tumour may be detected in the patient's blood. Theoretically, patients can be followed and monitored through analysis of ctDNA, which would reveal if the patient is responding to treatment, is in remission, or if mutations are becoming more or less prevalent as the result of time and/or treatment pressure. The challenge is development of a reliable method of detecting ctDNA, with adequate sensitivity and specificity to guide treatment.

Analysis of a novel energy absorbing roof anchorage connector for fall protection in lower strength roof construction

There is a large need for anchorage connectors (AC) on low strength structural roofs. A patent-pending AC has been designed to provide a secure point for workers on lower strength roofs while having energy absorbing capacity to limit damage to the structure in the event of a fall. With the advent of more and taller wood frame buildings the need for AC for low strength structural roofs is paramount. Through this proposal we aim to develop the next generation of Energy Absorbing Roof AC through optimizing the materials and design for broad market distribution. Working in partnership with Dr.

Pilot Study of the Safety and Efficacy of Different Potencies of Vaporized Marijuana Participants with Chronic, Treatment-Resistant Posttraumatic Stress Disorder (PTSD)

This study is among the first studies examining the effects of whole plant herbal cannabis on a variety of outcomes, including mental health conditions, anxiety, mood, and sleep quality. The interns will gain valuable experience in the field of medical cannabis, and will collect important data on the effects of varying strains of cannabis on anxiety, mood, sleep, and general well-being. The benefits of this
program of research are expected to be far-reaching, to both Canadians suffering from mental health conditions and to the partner organization.

Diagnostic screening for conscious awareness in brain injury and disease: Visual component

Since the mid 1970s, medical personnel have used the Glasgow Coma Scale (GCS) as an important tool to rate and describe levels of consciousness. This scale is rudimentary and subjective, often resulting in misdiagnoses in cases where people lack the capacity to communicate. In some unfortunate situations, severe neurological damage can render people unable to move. Inevitably, these people are deemed vegetative when in actuality; many are simply ‘locked in’. For years researchers have used cognitive event related potentials (ERPs) with modified EEG to assess receptive language capacity.

Evaluation of the CACE Homecare Curriculum

In January 2016, the Centre for Ambulatory Care Education (CACE) at Women’s College Hospital completed the Homecare Curriculum. This online, simulation-based program is designed to help personal support workers, nurses, and rehabilitation professionals provide better care for older adults who wish to stay in their homes. The program presents learners with 3 virtual home environments and 3 patient profiles. Alone, or with a team, users navigate these virtual homes, learn about home-based care and complete quizzes that test their comprehension of the material.

KINARM Standard Tests’ Task Scores: towards a validated and effective tool for communicating to clinical communities KINARM measures of brain function

KINARM Labs™ provide robust and objective measures of brain function and dysfunction by the precise measurement of human behavior with robotics. Created by neuroscientists, KINARM Labs allow clinician-scientists to detect and quantify the sensory, motor and cognitive impact of a diverse range neurological impairments caused by stroke, cardiac arrest, TIA, mTBI, concussion, MS or Parkinson’s - all in a short

Pressure Ulcer Biobank from Spinal Cord Injury Patients

Pressure ulcers (PUs) are a major health problem in people with spinal cord injuries (SCIs). PUs increase hospital admissions, with 25% of SCI treatment cost linked to PU management. Currently, treatment is limited and new therapeutic options are required. Wound fluid from PUs is invaluable for researchers as it allows a detailed study of the disease. However, no system is in place to systematically collect and store SCI PU wound fluid in British Columbia. In response, the aim of this proposal is to collaborate with the Rick Hansen Institute (RHI) to establish a PU biobank.

Targeting the GAS6/AXL Pathway in Acute Myeloid Leukemia Stem Cells with a Novel Combination Therapy

Blood cancer (leukemia) is common, with ~48,600 and 6,400 new cases expected in the United States and Canada respectively in 2016. The National Cancer Institute (US) calculated an overall 5-year survival rate of 56% for various blood cancers. This is because most current therapies are short-lived; drug resistance and relapse pose significant clinical problems. Life-long treatment is required, with potential long-term side-effects and a high cost.

Development and Evaluation of a Life Threatening Infections Point-of-Care Triage Test for the Fionet System

Febrile syndromes are among the most common causes of global illness accounting for approximately two billion episodes annually. However, most infections are self-limited and only rarely do they progress to critical illness. Our current inability to rapidly identify the small proportion of individuals who will progress to life-threatening infections (LTIs) is a major barrier to effective triage and precision management of serious infections. Our research has identified biomarkers with high diagnostic accuracy for LTIs.

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