Improving Patient Safety by Developing an Algorithm to Detect Patient Respiratory Status During Remifentanil Administration for Lithotripsy

Remifentanil, an anesthetic that is administered intravenously during acoustic shock wave treatment for kidney stones, depresses a patient's ability to breathe and can lead to apnea. Respiration is normally detected via standard patient monitors which sound alarms in the event that the patient ceases to breathe for a given length of time. However, a physician or nurse often intervenes before the alarms sound and is able to prompt the patient to breathe properly. The decision to intervene includes visual observation of respiration conditions, and requires vigilant monitoring.

Development of a Pharmacokinetic and Physiologic Model of Different Formulations of an Anti-tumoral Agent

In partnership with Labopharm, a leading company in optimizing the performance of small molecule drugs, a complete pharmacokinetic (PK) study of three new formulations of a commercially available drug will be performed. This study will be conducted in order to choose the most appropriate formulation in terms of bioavailability and absorption rate. Pharmacokinetics parameters of the drug will be estimated using different methods. Mechanisms of drug absorption, distribution, and elimination will also be identified.

Impact of Canadian Drug Policies on Economic, Clinical, and Humanistic Outcomes: A Systematic Review

Pharmaceuticals are among the most commonly used and important healthcare treatments in Canada. Third party healthcare payers, such as provincial departments of health and private insurers such as Blue Cross and Green Shield, use a variety of tools and techniques to balance the access, cost and quality of medications. Collectively, these tools and techniques are known as drug policies and they include things such as formulary restrictions, prior authorization forms and patient co-payments and deductibles.

Data Mining in the VISTA Clinical Trials Database

The project aims to apply data mining in the VISTA clinical trails database at the Geriatric Medicine Research Unit. The data contains information about Alzheimer’s disease (AD) patients, some of whom received cholinergic treatment and some of whom did not receive this treatment. Because of the variability of responses to treatment as well as the variability in the course of disease progression, it is difficult to identify the patterns robustly associated with improvement, which is crucial in justifying the choice of treatment.

Metric Development to Interpret Measures of Medication Compliance

Medication non-compliance is associated with poor outcomes in patients. Although different methods are currently used to measure compliance, the ability to translate this measure into a meaningful metric, which is interpretable for both methodologists and clinicians, has not yet been realized. Medication compliance has become an increasingly important area of research as policy makers perceive the extent and effect of the problem that non-compliance poses.

Mathematical Modeling in Pharmaceutical Development

Microtubules are a key constituent of the cell's structural framework and are responsible for a diverse range of functions within the cell. They are cylindrical polymers, 25 nm in diameter and can grow to be several hundred micrometers in length. Tubulin, the protein which is the main component of microtubules, self-assembles to form the walls of the cylinder in a highly-ordered, helical lattice arrangement. Functionally, microtubules fill a wide variety of roles within the cell. The function often considered most important is the role played in cell division.