Many therapeutic targets are proteins embedded in the membrane that surrounds the cell. Traditionally, such targets present major challenges, because they required the use of detergents to extract them from the membrane and to purify them. Such detergents can cause artefacts, hampering the development of novel therapeutics. Here we will test new methods that get rid of detergents during extraction, purification, or both.
Yeast are used on a massive scale in many industrial settings, such as production of food and beverages, nutrient supplements, pharmaceuticals, and others, totaling over $5 billion dollars in annual market value. Most yeasts currently used for industrial purposes are taken directly from nature and not optimized for the specific process requirements of industry. Currently, many tools for strain improvements require genetic modification of organisms, which does not allow for a non-GMO âcleanâ labeling.
This is a research and development (R&D) project. The primary objective is to develop a Smart Learning and Course Management System with a pilot demonstration of an entrepreneurship development course. The target audience for the course is students interested in learning the fundamentals of running a startup company. The secondary objective is to document and inform the development and learning analytics through design-based research.
Chronic heart failure (HF) is an epidemic affecting approximately 1.5-2% of Canada’s population (12% in patients over 80yrs) and the current one-year mortality rate after HF diagnosis remains disturbingly high at 25-40%. Even with treatment, many HF patients require hospitalizations during the course of their disease; in Canada HF is responsible for $3 billion in hospital costs annually.
With the maturity of renewable energy technology in recent years, micro-network has become an ideal power supply solution to the remote villages and islands. Recently, researchers have tried to reduce the cost of the system based on ideal assumptions. However, the factors that actually affect the system life cycle cost are varied. Including the control of the system, the maintenance mode of the system, the geographical factors of the power station and the configuration of the system will greatly affect the cycle cost of the whole system.
Onsite Domestic Wastewater Treatment and Reuse is emerging as a potential solution to the water shortages, eroding distribution infrastructure, and energy intensive treatment processes that are a fixture of the modern city. However, existing onsite treatment technologies fail to compactly treat water to a high enough quality for urban reuse without increasing per capita treatment energy use.
Hydra Energy Corporation Commercial Demonstration Project will be based in Prince George, British Columbia 12.4 MT/day of waste hydrogen will be captured, purified and transported to an onsite hydrogen refueling station from which (at least) 53 Class 8 tractor-trailer trucks will refuel daily. Hydraâs demonstration project can provide a significant reduction in fleet greenhouse gas(GHG) emissions, Particulate Matter and other air emissions. Hydra is currently testing the first prototype dual-fuel hydrogen/diesel heavy-duty class 8 truck in North America.
The proposed project will use classical animal models to investigate the therapeutic effects and associated side effects of extracts from the whole plant of different strains of cannabis. The targeted medical conditions include pain and chemotherapy induced nausea and vomiting (CINV). Our data and results will play a key role in pre-screening of cultivars to obtain best candidates suited for particular medical conditions, or that have lower side-effect liability.
It is well known that an adequate and stable income promotes health. Material security (e.g., housing, food, and service access) may operate distinctly from income security, yet may also be critically important to health. Nevertheless, material security and its relationship with employment is not well understood, an important oversight in research among people who use illicit drugs (PWUD) given that the ongoing need to acquire drugs may disrupt the translation of income security into material security.
Goldcorp recently announced a new initiative referred to as H2zero with the goal of reducing water usage in their mining operations by 80 to 100%. Mineral processing and specifically comminution and mineral separation are the main consumers of water. This research focuses on dry comminution technologies and represents a first step towards advancing dry comminution as part of a longer term goal and research intersect. A literature review will be conducted to compile information about existing and novel dry comminution technologies.