Optimizing Numerical Weather Prediction for Clean Energy

Modern weather forecasts are made by computers that solve the complicated equations for air motion, heat, and moisture. Different computer codes, called weather models, use different atmospheric approximations, creating slightly different forecasts. This forecast diversity is good, because the average of all forecasts is often the most accurate, and the spread between forecasts measures uncertainty.

Development of new approaches to promote proliferation of insulin producing pancreatic ?-cells in diabetic patients

Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic patients either by reducing ?-cell death or by increasing their proliferation is of great importance.

Optimization of novel drugs to treat cardiac arrhythmias

This project aims to validate and optimize drugs to treat heart rhythm disorders. The heart is a complex organ that uses tiny electrical signals to maintain a healthy rhythm. When these electrical signals are disturbed, it can change the regular rhythm, which can result in life-threatening consequences such as sudden cardiac death. Here, I will visualize one of the components of the heart that is responsible for the electrical signals, a specialized protein known as the ‘sodium channel’. I will look at the three-dimensional structure of this component both with and without drugs bound to it.

A systems biology approach to investigate chemoresistance in urothelial carcinoma of the bladder.

To perform a complete molecular analysis of muscle invasive bladder cancer (MIBC) before and after pre-operative chemotherapy to find changes responsible for resistance to treatment. Analysis will include a combination of DNA sequencing, RNA expression analysis and quantification of protein. Together this information will reveal the molecular landscape for these tumors.

Embedding a Climate Change videogame in High Schools: Towards a Teacher's Guide for Engaging Students with a Place-based Videogame – Future Delta 2.0

At the moment, BC has no comprehensive climate change curriculum in high schools, and educators lack coordinated materials to support its teaching. In an effort to narrow this gap, the Collaborative for Advanced Landscape Planning (CALP) at the Faculty of Forestry, UBC partnered with the Delta School District, to develop an educational and compelling videogame – Future Delta 2.0 (FD2), which brings together methods from commercial gaming a participatory research to address climate change science in an innovative place-based game environment.

Formulation of Cationic Peptides by Hyperbranched Polyglycerols for the Treatment of Chronic Rhinosinusitis

Chronic rhinosinusitis is a common condition in which the cavities in the nasal channel become inflamed and swollen. This condition interferes with drainage and causes mucus to build up. Delivery of the positively charged proteins containing short chains locally to the nasal area can be used for the treatment of this problem. This proposal suggests synthesis and characterization of negatively charged polymeric systems with specific modifications to bind to these proteins and stabilize them.

Modern tools for selecting disease-resistance traits in honey bees

Over the past six and a half years we have developed a way to measure disease resistance in honey bees using a molecular diagnostic approach, similar to the tests done every day in hospital laboratories. We have then used this method to selectively breed bees that are, indeed, more resistant to disease. This is akin to the selective breeding humans have practiced for millennia on all our agricultural crops and livestock, only using modern tools. It is not genetically modifying bees.

Pool-riffle design for river restora

Professionally practicing Civil Engineers and Earth Scientists engage in stream restoration actions in order to enhance freshwater habitats for salmon, trout, and a variety of other species. There is a wealth of procedures and standards available to help practitioners develop design plans. However, there is a lack of specific guidelines to help identify stream reconstruction details that will give the overall effort a greater likelihood of meeting performance expectations and criteria after the project has been constructed.

Web-based mobile mental health technology in an acute care setting

The use of mobile technology is on the rise including access to mental health-related applications and websites. There is a wealth of information available and numerous intervention strategies focused on treatment and support for mental health concerns. However, inpatient psychiatry often discourages patients' use of electronic technologies and web-accessible mobile phones. The proposed study involves brief interviews with patients admitted to inpatient care at St.

In-silico identification of driver alterations and prediction of therapeutics targeting actionable drivers in prostate cancer

Cancer arises as a result of deleterious aberrations in the DNA, RNA and proteins of cells. The accumulation of genetic abnormalities, over lifetime, perturbs critical functions of cells, which may ultimately give rise to tumor. However, vast majority of these aberrations are not essential and only small fractions, known as “driver” genes, are critical for tumor growth. Identification of driver aberrations is a challenging task, but is critical for optimal cancer management. Prostate cancer (PCa) is the most common cancer to affect Canadian men.