Blood biomarkers of asthma

Allergic asthma is a condition of the airways characterized by airway constriction and hyperresponsiveness upon allergen exposure. About half of the allergic asthmatic individuals experience only an acute airway constriction (early response) within several minutes upon exposure to allergen while the other half of individuals experience not only an acute airway constriction but also a chronic airway constriction plus inflammation (late response) within several hours after the allergen exposure. It is not clear why the late response is not developed in all sensitized individuals.

Developing spatial and participatory resolutions for the Canadian Aboriginal housing crisis

The Aboriginal housing situation in Canada is in crisis with a lack of culturally and environmentally appropriate housing. A Participatory Approach towards Housing Solutions (PATHS) Framework has been developed that recognizes and visualizes the strengths and limitations of communities, and assesses pathways with which they may achieve their housing goals. Communities are actively engaged in order to identify their aspirations and translate them into measurable indicators and associated capitals.

High Impedance Fault Detection System

A High Impedance fault (HIF) occurs when an energized primary conductor comes in contact with a semi-insulated object such as tree, structure or equipment, or falls to the ground. HIFs on distribution systems are extremely difficult to detect because they do not generate enough fault current to be detectable by conventional overcurrent relays or fuses. HIFs do not pose imminent danger to power system equipment because they have very little fault current. However, they are a considerable threat to public safety.

Intestinal Inflammasomes: Defining Their Role in IBD

Inflammatory Bowel Disease (IBD) is thought to develop in people when their gut bacteria leak out of their intestines, and cause chronic gut inflammation. We recently found that the cells that line the guts of healthy people possess a specialized defense system called an inflammasome.
In preliminary studies, the inflammasome seems to prevent the gut from becoming leaky, and helps it fight bacteria. Interestingly, some people with IBD are known to be missing inflammasomes.

Effect of rumen protected vitamin B complex supplementation on ovarian dynamics and uterine gene expression on day 15 of the cycle or pregnancy

Lactating dairy cows have extensive embryonic loss, but the mechanisms that lead to this failure to maintain pregnancy are not clearly understood. It is suggested that high-producing dairy cows are marginally deficient in nutrients such as Vitamin B complex molecules, selenium etc., which are positively associated with health and reproduction.

Development and Demonstration Engine Technology for Class 8 Heavy Duty Trucks Fueled by Waste Hydrogen

Hydra Energy Corporation Commercial Demonstration Project will be based in Prince George, British Columbia 12.4 MT/day of waste hydrogen will be captured, purified and transported to an onsite hydrogen refueling station from which (at least) 53 Class 8 tractor-trailer trucks will refuel daily. Hydra’s demonstration project can provide a significant reduction in fleet greenhouse gas(GHG) emissions, Particulate Matter and other air emissions. Hydra is currently testing the first prototype dual-fuel hydrogen/diesel heavy-duty class 8 truck in North America.

Pressure Ulcer Biobank from Spinal Cord Injury Patients

Pressure ulcers (PUs) are a major health problem in people with spinal cord injuries (SCIs). PUs increase hospital admissions, with 25% of SCI treatment cost linked to PU management. Currently, treatment is limited and new therapeutic options are required. Wound fluid from PUs is invaluable for researchers as it allows a detailed study of the disease. However, no system is in place to systematically collect and store SCI PU wound fluid in British Columbia. In response, the aim of this proposal is to collaborate with the Rick Hansen Institute (RHI) to establish a PU biobank.

Targeting the GAS6/AXL Pathway in Acute Myeloid Leukemia Stem Cells with a Novel Combination Therapy

Blood cancer (leukemia) is common, with ~48,600 and 6,400 new cases expected in the United States and Canada respectively in 2016. The National Cancer Institute (US) calculated an overall 5-year survival rate of 56% for various blood cancers. This is because most current therapies are short-lived; drug resistance and relapse pose significant clinical problems. Life-long treatment is required, with potential long-term side-effects and a high cost.

In-vivo translation of neuronal cell regeneration/reprogramming protein in mouse with chronic spinal cord injury

Chronic spinal cord injury (SCI) is a debilitating disease with enormous economic and personal impact. To date there is no approved treatment that can repair the severed nerves found in SCI. The research project entails translational development of an early stage experimental protein drug candidate that has shown remarkable ability to trigger dormant human stem cells to rapidly differentiate into functional neuronal populations. Both the drug candidate’s safe dosage range and efficacy in regenerating neurons at the site of injury will be studied.

Mechanical and physical beneficiation of concentrates from printed circuit board processing

E-waste is one of the fastest growing waste streams in the world in terms of volume and its environmental impact on the planet. Printed circuit boards represent a major portion of the e-waste that contains higher values. The metal fraction from the circuit boards is extracted for its value while the non-metal fraction is often landfilled. The proposed research looks into the disposal guidelines for landfills and incineration and quality requirements for being used as a filler and secondary materials source will also be studied.

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