Annual survey of Ontario’s publicly funded education system

Over the past 15 years, People for Education has conducted a survey of Ontario’s publicly funded schools. From this large-scale survey, People for Education produces research reports on public education in Ontario that are widely disseminated to the public and have been instrumental to informing educational policy in the province.

Radiation Modulated Nanomedicine Delivery

The current survival times for breast cancer patients with brain metastasis range from 2 to 16 months suggesting a strong need for improvements in their therapeutic care. Although radiation therapy is the standard of care for these patients, combination with chemotherapy has demonstrated promising therapeutic benefits. The hypothesis of this research program is based on the belief that optimizing combination of radiation and chemotherapy has the potential to significantly improve the treatment outcome for patients with breast cancers that have metastasized to the brain.

Towards Detection of Subclinical Joint Bleeds in Hemophiliacs: Advanced Imaging

This project aims to assess how the use of the novel “ultra-short echo-time” (UTE) MR imaging technology can “add value to” conventional MRI for detection and quantification of blood products in hemophilic joints. We will test this novel technology in joints of hemophilic patients with different stages of arthropathy presenting with blood products at different stages of degradation as compared with existing MRI sequences.

Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases - Year Two

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes.

A Sequential Model to Recognize Depression Acuity Using Social Media and Physical Activity

Over 350 million people worldwide suffer from depression. A key part in diagnosing depression is screening questionnaires, which rely on patient self-reports of the recent past. With the advent of social media and wearable devices, there is an opportunity for a novel approach to detecting when a patient diagnosed with chronic depression becomes acute. In this project, we use social media data and physical activity data to detect depression acuity. Social media is indicative of an individual’s mental state. Physical activity is an indicator of physical wellness.

Acoustics Modeling of ecoCUBE

Emissions control is an important part of any environmental policy. However, in dense urban environments and other locations, it is important to deal with sound as well. To ensure effective pollutant mitigation while also ensuring minimal acoustic disturbance, it is necessary to look at computer models that look at these factors simultaneously. This work will provide SPI with tools necessary for acoustic models while ensuring that their current products meet environmental requirements.

Leveraging data analytics in modern tax function

Investigating geographical footprints of income shifting by multinational enterprises. PwC owns a large data set across all industries in Canada from its tax consulting engagements and annual standard tax filings from clients. This growing data source is an opportunity for accurate tax benchmarking, trend analysis and gaining deeper insights by transforming them into market differentiating knowledge that can be dynamically shared and accessed by multiple teams.

Development of an Equity Risk Score System and Interest Rate Shock Modelling for Value-at-Risk Computation

The objective of this research is twofold: to improve existing risk management framework to assess interest rate shocks, and to develop a new risk factor model to create an equity risk score system to help guide investment decisions.
The first part of this research project involves the development of an equity risk score system to better evaluate the quality of an investment.

Optimization of parameters in Blade Element model for Helicopter Training Simulators

Helicopter training simulators are an important part of improving the safety of both civil and military helicopter operations. The most important part of helicopter training simulators is the model of the helicopter dynamics since it drives all the other simulator subsystems. This project aims to provide CAE with a more automated and accurate method for determining the parameters within their blade element helicopter model such that it matches the real helicopter behaviour.

Innovative design of a sound numerical model calibration process: from lab tests to input data

Geomechanica Inc. develops simulation software (Irazu) for rock engineering applications. This numerical software has been used in several peer-reviewed research publications in the rock mechanics field. A key challenge in the numerical modelling of rock masses is the selection of appropriate input parameters. The objective of this work is to develop a solution to streamline the laboratory testing and integration of the results into Irazu models. As a result, the time needed to build a model will be significantly reduced and the uncertainties in the model inputs will be mitigated.

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