Preclinical evaluation of novel meningococcal vaccines

Neisseria meningitidis (Nme) is a bacterial pathogen that often colonizes the upper respiratory tract of humans without symptoms, but which may also develop into rapidly-progressing sepsis and meningitis that can be fatal. Nme has evolved elegant means to specifically interact with human cells and proteins in order to colonize, survive and the evade host immune system. In partnership with Vaxiron Inc., we are developing a novel class of vaccines that target systems involved in Nme acquisition of the essential micronutrient, iron, during infection.

Chemical and Microbial Contaminants of Medical Air in Healthcare Institutions

Administration of supplemental oxygen through medical air is a life-supporting measure essential for the management of severe primary respiratory conditions as well as secondary lung injury due to systemic insults such as trauma and sepsis. This medical air is often produced on site through devices which draw, compress and filter outside air in order to redirect it into buildings. However, depending on the outdoor conditions, the state of the ventilation system or the presence of microorganisms, this air can be contaminated.

Development of an integrated modelling framework for eutrophication risk assessment and adaptive management implementation

In water quality management, mathematical models are used to understand ecological processes, to predict aquatic ecosystem dynamics, to evaluate management alternatives/climatic scenarios, and to support the policy making process. Environmental models involve substantial uncertainty due to their structure, unknown parameters, and errors associated with calibration data and other inputs. This research program aims to address the urgent need for credible modelling tools by combining environmental mathematical modelling with Bayesian analysis.

Mystery or romance? How Big Data can help you pick your next book

Kobo’s Big Data Director Darius Braziunas says he knew early on that to stay competitive in the e-book world Kobo would need to collaborate with university researchers to take their products to the next level.

Annual survey of Ontario’s publicly funded education system

Over the past 15 years, People for Education has conducted a survey of Ontario’s publicly funded schools. From this large-scale survey, People for Education produces research reports on public education in Ontario that are widely disseminated to the public and have been instrumental to informing educational policy in the province.

Radiation Modulated Nanomedicine Delivery

The current survival times for breast cancer patients with brain metastasis range from 2 to 16 months suggesting a strong need for improvements in their therapeutic care. Although radiation therapy is the standard of care for these patients, combination with chemotherapy has demonstrated promising therapeutic benefits. The hypothesis of this research program is based on the belief that optimizing combination of radiation and chemotherapy has the potential to significantly improve the treatment outcome for patients with breast cancers that have metastasized to the brain.

Towards Detection of Subclinical Joint Bleeds in Hemophiliacs: Advanced Imaging

This project aims to assess how the use of the novel “ultra-short echo-time” (UTE) MR imaging technology can “add value to” conventional MRI for detection and quantification of blood products in hemophilic joints. We will test this novel technology in joints of hemophilic patients with different stages of arthropathy presenting with blood products at different stages of degradation as compared with existing MRI sequences.

Development and Delivery of Inhibitors for Viral Pathogenic Deubiquitinases - Year Two

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to evade the immune system by interfering with host ubiquitin-dependent processes.

A Sequential Model to Recognize Depression Acuity Using Social Media and Physical Activity

Over 350 million people worldwide suffer from depression. A key part in diagnosing depression is screening questionnaires, which rely on patient self-reports of the recent past. With the advent of social media and wearable devices, there is an opportunity for a novel approach to detecting when a patient diagnosed with chronic depression becomes acute. In this project, we use social media data and physical activity data to detect depression acuity. Social media is indicative of an individual’s mental state. Physical activity is an indicator of physical wellness.

Leveraging data analytics in modern tax function

Investigating geographical footprints of income shifting by multinational enterprises. PwC owns a large data set across all industries in Canada from its tax consulting engagements and annual standard tax filings from clients. This growing data source is an opportunity for accurate tax benchmarking, trend analysis and gaining deeper insights by transforming them into market differentiating knowledge that can be dynamically shared and accessed by multiple teams.

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