Near-Infrared Dyes for Next-Generation Motion detection technology

Currently, the traditional use of the dye-sensitized solar cell (DSSC) is well-known in the science community as an effective photovoltaic technology, where it works best in diffuse lighting conditions. With the insights brought from this research project, the DSSC can also be transformed into an optically sensing motion sensor based on the dye utilized within it. This project will focus on synthesizing a family of organic dyes that absorb in the near-infrared region, optimal for detecting movement. The second half of the project will utilize those dyes in device fabrication.

Anticancer activities and drug-drug interaction of extracts from long pepper, rosemary, lemongrass and white tea with chemotherapeutics

Natural extracts have potential as anti-cancer therapeutics. These botanical materials are well tolerated and are safe to be given as supplements over long periods of time. This project aims to provide scientific and clinical validation of these extracts for their anticancer effects and sensitization of cancer cells to standard chemo regiments.

Towards Clinical Use of Whole Genome Sequencing based Tests in a Clinical Setting - Year two

Using genomics in clinical care has the potential to treat patients more efficiently. There have been a number of recent discoveries of genomic assays that can guide treatment. However, most genomic data is generated in a research setting and useful health data only in a clinical setting. Translating potential genomic research into a clinical setting as well as bringing clinical data into a research setting faces significant challenges. One challenge is technical: genomic tests often take days to run and are thus not efficient enough for a clinical use.

Development of Fungal-Specific Stress Response Inhibitors for the Treatment of Fungal Infections – Part 2

Drug resistance of medically relevant microorganisms poses a grave threat to human health and has severe economic consequences. Fungal pathogens pose an additional complication as they are closely related to their human host. Current therapies to treat fungal infections are limited and drug resistance has already emerged in the clinic. We have conducted extensive research on fungal drug resistance mechanisms and propose to target these mechanisms in combination with existing antifungals.

Semisynthetic Strategies for the Production of Cannabinoids from Cannabis Sativa

Although recreational and medicinal marijuana is legal in Canada regulations limit the content of certain cannabinoids, such as ?9-tetrahydrocannabinol (?9THC) in commercially grown strands. With close collaboration with our industrial partner Plantbiois Ltd., this research project will develop methods to produce ?9THC by synthetic conversion from highly abundant cannabinoids in unregulated, low THC strains.

Formulation and Process Optimizations for the Manufacturing of Cannabinoid Nanoemulsions

Coming into force in October 2019, amendments to the Canadian Cannabis Regulations will introduce guidelines governing the legal production and sale of cannabis-infused extracts, edibles, beverages and topicals. These new products are at the forefront of the natural health product (NHP) and consumer product goods (CPG) industries, but challenges associated with their formulation, production and stability are quickly mounting.

Identifying probiotics that modulate mitophagy in models of mitochondrial dysfunction

Mitochondria are critical producers of energy and are the platform for various metabolic reactions that support cellular health. Mitochondria suffer from a variety of damage as a consequence of housing these reactive pathways. In order for cells and organisms to survive this damage, dysfunctional mitochondria are removed from the cell in a process termed mitophagy. The goal of this proposal is to identify probiotics that enhance mitophagy, thereby serving as ideal promoters of health by preserving mitochondrial, cellular and organismal function.

Systematic development of novel peptide-derived therapeutics for the inhibition of lysine-modifying enzymes for the treatment of cancer

Cancer will affect 2 in every 5 Canadians in their lifetime, with just over 25% representing new breast cancer diagnoses in women. Despite significant progress in the treatment of the most common cancer in women, resistance to chemotherapeutic agents remains a consistent obstacle in terms of the successful treatment of many types of breast cancers. The Mitacs-funded collaboration between NuvoBio and the Biggar lab at Carleton University is seeking to address this issue by systematically designing and developing peptide-based inhibitors that hold the promise as new therapeutics.

Effects of low-dose radiation on immune parameters, antioxidant and metabolic signalling and implications in the development and progression of mammary cancer - Year two

Recent studies have called into question the Linear No Threshold (LNT) model of radiation protection, which predicts a linear increase in cancer risk with low-dose radiation exposure. However, current experimental evidence suggests that low-dose radiation (LDR,

Understanding the Mechanism of Probiotics for Human Health

DoseBiome has developed a new probiotic that targets several aspects of oral health: dental caries, periodontal diseases, and halitosis. This project aims to understand the exact mechanism of our probiotic's inhibitory properties against the pathogens associated with the above diseases. DoseBiome is a new start-up in the probiotic/microbiome health sector, and this project will allow for improved technology and manufacturing processes for our oral probiotic line.

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