Development of Fungal-Specific Stress Response Inhibitors for the Treatment of Fungal Infections – Part 2

Drug resistance of medically relevant microorganisms poses a grave threat to human health and has severe economic consequences. Fungal pathogens pose an additional complication as they are closely related to their human host. Current therapies to treat fungal infections are limited and drug resistance has already emerged in the clinic. We have conducted extensive research on fungal drug resistance mechanisms and propose to target these mechanisms in combination with existing antifungals.

Semisynthetic Strategies for the Production of Cannabinoids from Cannabis Sativa

Although recreational and medicinal marijuana is legal in Canada regulations limit the content of certain cannabinoids, such as ?9-tetrahydrocannabinol (?9THC) in commercially grown strands. With close collaboration with our industrial partner Plantbiois Ltd., this research project will develop methods to produce ?9THC by synthetic conversion from highly abundant cannabinoids in unregulated, low THC strains.

Formulation and Process Optimizations for the Manufacturing of Cannabinoid Nanoemulsions

Coming into force in October 2019, amendments to the Canadian Cannabis Regulations will introduce guidelines governing the legal production and sale of cannabis-infused extracts, edibles, beverages and topicals. These new products are at the forefront of the natural health product (NHP) and consumer packaged goods (CPG) industries, but challenges associated with their formulation, production and stability are quickly mounting.

Identifying probiotics that modulate mitophagy in models of mitochondrial dysfunction

Mitochondria are critical producers of energy and are the platform for various metabolic reactions that support cellular health. Mitochondria suffer from a variety of damage as a consequence of housing these reactive pathways. In order for cells and organisms to survive this damage, dysfunctional mitochondria are removed from the cell in a process termed mitophagy. The goal of this proposal is to identify probiotics that enhance mitophagy, thereby serving as ideal promoters of health by preserving mitochondrial, cellular and organismal function.

Systematic development of novel peptide-derived therapeutics for the inhibition of lysine-modifying enzymes for the treatment of cancer

Cancer will affect 2 in every 5 Canadians in their lifetime, with just over 25% representing new breast cancer diagnoses in women. Despite significant progress in the treatment of the most common cancer in women, resistance to chemotherapeutic agents remains a consistent obstacle in terms of the successful treatment of many types of breast cancers. The Mitacs-funded collaboration between NuvoBio and the Biggar lab at Carleton University is seeking to address this issue by systematically designing and developing peptide-based inhibitors that hold the promise as new therapeutics.

Effects of low-dose radiation on immune parameters, antioxidant and metabolic signalling and implications in the development and progression of mammary cancer - Year two

Recent studies have called into question the Linear No Threshold (LNT) model of radiation protection, which predicts a linear increase in cancer risk with low-dose radiation exposure. However, current experimental evidence suggests that low-dose radiation (LDR,

Understanding the Mechanism of Probiotics for Human Health

DoseBiome has developed a new probiotic that targets several aspects of oral health: dental caries, periodontal diseases, and halitosis. This project aims to understand the exact mechanism of our probiotic's inhibitory properties against the pathogens associated with the above diseases. DoseBiome is a new start-up in the probiotic/microbiome health sector, and this project will allow for improved technology and manufacturing processes for our oral probiotic line.

Modeling the Removal of Mine-impacted Water Species Using Freezing Technologies Focused on Frazil Ice Formation

The development of environment-friendly freezing technologies to contaminated water is a potential solution for water treatment in regions with cold weather conditions and vulnerable to anthropogenic impact. The results of laboratory tests fulfilled by Core Geoscience Services Inc. on the removal of mine-impacted water species through ice formation along with other publicly available data will form a basis for the next stage of research comprising quantitative analysis and mathematical modelling.

Identifying and validating rational combinatorial therapies for treatment-refractory Glioblastoma

Glioblastoma (GBM), the most common and deadly form of primary brain cancer in adults. After diagnosis, GBM patients undergo standard therapy, including surgery, chemotherapy and radiation therapy. Unfortunately, disease relapse is inevitable and patients face a median survival of less than 15 months. A small population of tumor cells, known as brain tumor initiating cells (BTICs), have been shown to resist standard therapy and lead to relapse. Using a multi-pronged approach, we are developing novel and rational combinatorial therapies against treatment-resistant GBM BTICs.

Developing surfactant–nanoparticle systems for enhanced oil recovery

There has been a growing interest in the application of nanotechnology for enhanced oil recovery (EOR). Nanoparticles possess unique physical and chemical properties due to their small size. In addition, their surface coating can be easily tailored for a particular EOR application. The proposed research will develop surfactant-coated nanoparticles as an additive. These nanoparticles will increase the recovery of residual oil in unconventional reservoirs found in Saskatchewan. Silica nanoparticles will be coated with zwitterionic surfactants.

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