Evaluation of neuro-protective effects of novel water-soluble formulation of Ashwagandha root extract alone and in combination with water-soluble Ubisol Q10 using in vitro and in vivo models of Parkinson’s disease

There is an increase in brain diseases like Alzheimer’s and Parkinson’s diseases as the number of aged individuals is increasing. Currently there is no treatment available that can halt the progression of these diseases. Previous work has shown that a natural compound CoQ10 can prevent brain cell death. Similarly an Ayurvedic Herbal extract, Ashwagandh Root Extract has also shown promising results in some studies. In the present research project we will prepare a novel water-soluble formulation of CoQ10 and Ashwagandha Extract using a patented technology of Nextremedies Inc.

Selective breeding of honey bees

Over the past eight years we have a diagnostic test for disease resistance in honey bees and then attempted to use this test to selectively breed disease-resistant bees. The bees selected in this way appear to not lose other economically important traits (e.g., honey production) but are far better equipped to deal with disease than ‘average’ bees. This then opens up many doors, some of which we would like to pursue here. First and foremost though is to get the tools we have developed into the hands of the bee industry.

Functional Characterization of Mammaglobin-1 Isoform in Breast Cancer

Many genes are implicated in the development and progression of breast cancer. One of these genes, mammaglobin 1 (MGB1), is specifically found in breast cells. MGB1 is routinely used for the detection of invasive breast cancer that migrate to distant organs of the body and form a secondary tumor. However, the specific role of MGB1 in breast cancer progression is still unknown. Our preliminary findings suggest that MGB1 is a potent inducer of cancer cell aggressivity. More recently, we have observed that the MGB1 gene is capable of generating multiple forms of MGB1.

Development of Fungal-Specific Stress Response Inhibitors for the Treatment of Fungal Infections

Drug resistance of medically relevant microorganisms poses a grave threat to human health and has severe economic consequences. Fungal pathogens pose an additional complication as they are closely related to their human host. Current therapies to treat fungal infections are limited and drug resistance has already emerged in the clinic. We have conducted extensive research on fungal drug resistance mechanisms and propose to target these mechanisms in combination with existing antifungals.

Computational and machine learning approaches to improve design and screening of high bioactivity peptides for drug discovery

The cost of developing new drugs is now widely acknowledged by industry leaders as prohibitive, with some estimates now in excess of $ 5B per drug. It is imperative that new approaches are developed to mitigate the cost and time required to bring new drugs to market. To help achieve this, we contend that new techniques in machine learning must be brought to bear on the drug development process.

Development of novel, systematic methods for expanding, screening, and selecting biodiversity in industrial yeast strains

Yeast is arguably the most important industrial microorganism in the world, playing a critical role in the fermentation of food and beverage products, as well as cellular factory for production of biofuels, chemicals, and pharmaceuticals. In order to produce such a range of products efficiently and economically, specialized yeast must be optimized for each task. Current tools for yeast optimization are lacking, especially in the sectors of food, beverage, and feed, where consumers demand non-GMO yeast products.

National Smart Vehicle Demonstration and Integration Project

In a context of global warming, it is essential to find green alternatives to public transportation. The National Smart Vehicle Demonstration Project aims to improve mobility options for Canadians by advancing the implementation of low-speed electrified autonomous shuttles (LSAs). This project aims to support job growth in the design of technologically advanced electrification, sensing, communication and cybersecurity tools that support LSAs.

Acetal-Free carbohydrate antigens and their multivalent display for lung cancer immunotherapy

This collaboration between pharmaceutical company NuvoBio and a Research Team led from the University of Windsor and working with Dalhousie and the University of Western Ontario seeks to develop a new vaccine for lung cancer. The students and postdoctoral fellows will be making new types of molecules and investigating some underlying questions about how we formulate vaccines, as well as preparing these promising compounds and studying their safety an efficiency in preventing and eliminating lung cancers.

Evaluation of NanoDendrixTM stability; phytoglycogen resilience in simulated oral cavity conditions

NanoDendrix™ is a completely natural form of glycogen, sourced and produced from plants by a patented green process developed in Guelph, Ontario. Recent studies have revealed many valuable properties and performance characteristics of NanoDendrix, such as its antimicrobial effects, which have wide-ranging implications for clinical use. The proposed internship will evaluate NanoDendrix for use in combating periodontal disease. First, the intern will evaluate the stability and functional performance of PhyoSpherix in conditions that mimic those of the oral cavity.

Developing biomarker identification tools for neurodegenerative diseases

Neurodegenerative diseases have caused massive economic burden on the healthcare system as well as reduced patient and caregiver’s quality of life. Identifying biomarkers for early clinical diagnosis, tracking of disease progression, and evaluation of treatment therapies is critical. However, developing such tools remains a significant challenge.