Therapeutic Strategies for Restoring Palmitoylation and Autophagy in Neurodegeneration

The cellular clearance pathway autophagy is required for degrading toxic proteins and damaged organelles, but is disrupted in many neurodegenerative diseases. During induction many autophagy regulators quickly localise to membranes from the cytosol. The Martin lab has identified palmitoylation, which involves the addition of the fatty acid palmitate to cysteine residues, as a potential regulator to direct autophagy proteins to membranes.

Quantifying the value and risk of restoring wetland habitats in agricultural landscapes - Year two

Wetlands provide critical habitat and valuable ecosystem services. Land use conversion in Ontario, however, has led to substantial wetland loss. The restoration of wetlands on agricultural properties has the potential to offset wetland loss, yet these wetlands are also susceptible to contamination by pesticides.

High Throughput Phenotyping of Spectrally-Optimized Plant Growth

Light is essential to plant growth and development. Despite being established in plant growth systems, current light systems on the market lack the ability to replicate key daily events such as dawn and dusk differences in light quality and intensity that occur naturally. Edmonton, Alberta based technology company G2V Optics Inc has commercialized a precision, programmable-spectra lighting technology aimed at reducing energy inputs for greenhouse food production. Collaboration between the Uhrig lab and G2V Optics successfully generated large amounts of data (e.g.

Antigen Tracking of the DPX-R9F immunotherapy using MRI – Part 2

IMV Inc. is developing injectable cancer immune therapy using the company’s DPXTM technology. DPX is a patented formulation that displays excellent tumor control and provides a long lasting and specific effect. The way by which this therapy exerts its effect is unclear but the translational team at IMV is determined to discover its mechanism of action and why their proprietary DPX technology delivers superior responses in comparison to other forms of injectable therapies.

Exploring Consumer and Restaurant Employee Perspectives Towards Food Allergy Risk Communication Strategies

Our research studies aim to gain a better understanding of how restaurants communicate risk to people with food allergies from the perspectives of customers and restaurant staff. We seek to understand what methods are used to communicate risk, what methods are most effective, and what strategies restaurants take to make the public aware of the risks and risk-mitigation efforts at their restaurant.

Advancing biomonitoring eDNA practices. The case of PCR inhibition and implications on eDNA detections

Conventional biomonitoring methods based on capture and observations can be difficult, destructive of habitat, stressful for the organisms, inefficient, and expensive. Living organisms shed DNA into the environment (eDNA) and this signal can be detected using molecular methods. eDNA allows species detection without physical observation or capture. The non-invasive nature of eDNA is essential for revealing elusive and invasive species.

Complementary and competitive interactions between wild and managed bees

A diversity of native bee species inhabit agricultural and urban landscapes and can be more effective pollinators than the widely employed European honey bee. However, honey and wild bee communities often overlap, which means these bees compete for the same floral resources. Studies of competition between wild and managed pollinators are limited due to methodological constraints. This restricts our ability to predict how pollination and bee diversity will be affected by changes in pollinator community composition.

Development, implementation and validation of new anti-E6 therapeutics for the treatment of HPV-associated cancer

Human papillomaviruses (HPVs) are responsible for almost all cervical cancers. Current treatment available relies on chemo- or radiation-therapy or surgery. These methods have several side-effects with high morbidity and survival of just ~ 70%. Our lab, therefore, develops a more patient-centered approach based on targeting the viral E6 protein, the main culprit of carcinogenesis in HPV-related malignancies.

Impact of Wind Energy Turbines on Bat and Bird Mortality

In this Mitacs-funded project, a postdoctoral researcher will work with partners at Trent University and Bird Studies Canada to expand our understanding of how wind turbines affect birds and bats. We will leverage an extremely detailed database on wind-wildlife interactions that is managed by Bird Canada. Using these data, we will investigate whether bat and bird mortality are affected by turbine characteristics including height and the area swept by the turbine blades.

Assessing the lice cleaning efficacy and diet of lumpfish in Canadian Atlantic salmon sea cages using metabarcoding and conventional diet analysis

The salmon aquaculture industry is a highly profitable industry, known to contribute significantly to the Canadian economy. During this time an ectoparasite called the sea louse may infect the salmon leading to animal welfare concerns a significant economic loss. Lumpfish are a species of cleaner fish used as a biological control for sea lice and offer a more sustainable and ecologically friendly option for sea lice management than previous chemical controls. They are a recent addition to Canadian aquaculture, and their cleaning efficacy must be well understood under Canadian conditions.