Mechanistic characterization of voltage sensor-targeted Kv7 activators

Epilepsy is a complex disorder, affecting roughly 1% of the global population. Treatments are available, but many patients (~1/3) are resistant to existing therapies, which have become economically challenging. In this project we will investigate a new class of anti-epileptic drugs that target neuronal voltage-gated Kv7 potassium channels. The intern will characterize the mechanism of action of Kv7 channel openers targeting the pore and the voltage sensor accelerating the development of therapeutics for epilepsy.

Advancing methods and understanding: Status and drivers of mammal populations in Alberta

Biodiversity loss is a major concern worldwide. Alberta’s has abundant natural resources; however, developing these natural resources can impact species, including mammal species and those valued by the public. Understanding the impacts of disturbance on populations of mammals is necessary in order to inform environmental management.

The development of a serum-free media formulation for cultured meat production

Cultured meat production has enormous potential to supplement the global protein supply. However, it has yet to become a consumer product due to high production costs, which are mainly attributed to the cell growth media. We intend to develop a cheap and effective culture media for the growth of animal cells for cultured meat applications. Many traditional cell growth medias rely on supplementation with foetal bovine serum.

Investigation of the effect of UV-LEDs on plant secondary metabolites

We wish to explore methods to make indoor plant growth more efficient. In many industries (especially the herb and vegetable greenhouse business), industry uses inefficient lighting options because they seek to supplement the visible light spectrum with UV wavelengths. We propose to use LED lamps that include UV bulbs to test whether this lamp will be a benefit to indoor growers.

Fostering Indigenous Small-scale fisheries for Health, Economy and food Security in Cree communities of northern Quebec (FISHES)

Northern fisheries are facing major changes and reducing the negative impacts is crucial for communities tied to the fisheries for their food security and culture. The identification of regions important for subsistence, commercial and recreational harvesting and whether they comprise genetically distinct groups of populations is a key requirement for adaptive co?management of harvest. Our team is comprised of researchers and Indigenous collaborators that combine the expertise for implementing knowledge at the interface between genomics and fisheries management.

Therapeutic Strategies for Restoring Palmitoylation and Autophagy in Neurodegeneration

The cellular clearance pathway autophagy is required for degrading toxic proteins and damaged organelles, but is disrupted in many neurodegenerative diseases. During induction many autophagy regulators quickly localise to membranes from the cytosol. The Martin lab has identified palmitoylation, which involves the addition of the fatty acid palmitate to cysteine residues, as a potential regulator to direct autophagy proteins to membranes.

Quantifying the value and risk of restoring wetland habitats in agricultural landscapes - Year two

Wetlands provide critical habitat and valuable ecosystem services. Land use conversion in Ontario, however, has led to substantial wetland loss. The restoration of wetlands on agricultural properties has the potential to offset wetland loss, yet these wetlands are also susceptible to contamination by pesticides.

High Throughput Phenotyping of Spectrally-Optimized Plant Growth

Light is essential to plant growth and development. Despite being established in plant growth systems, current light systems on the market lack the ability to replicate key daily events such as dawn and dusk differences in light quality and intensity that occur naturally. Edmonton, Alberta based technology company G2V Optics Inc has commercialized a precision, programmable-spectra lighting technology aimed at reducing energy inputs for greenhouse food production. Collaboration between the Uhrig lab and G2V Optics successfully generated large amounts of data (e.g.

Antigen Tracking of the DPX-R9F immunotherapy using MRI – Part 2

IMV Inc. is developing injectable cancer immune therapy using the company’s DPXTM technology. DPX is a patented formulation that displays excellent tumor control and provides a long lasting and specific effect. The way by which this therapy exerts its effect is unclear but the translational team at IMV is determined to discover its mechanism of action and why their proprietary DPX technology delivers superior responses in comparison to other forms of injectable therapies.

Exploring Consumer and Restaurant Employee Perspectives Towards Food Allergy Risk Communication Strategies

Our research studies aim to gain a better understanding of how restaurants communicate risk to people with food allergies from the perspectives of customers and restaurant staff. We seek to understand what methods are used to communicate risk, what methods are most effective, and what strategies restaurants take to make the public aware of the risks and risk-mitigation efforts at their restaurant.

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