Isolation, characterization and culture maintenance of stem cells from human hair follicle mesenchyme Year Two

Stem cells and other pluripotent cells are under active investigation for the development of new therapeutic treatments to regenerate and repair diseased and damaged tissues. Published studies indicate that some mesenchymal cells derived from adult human hair follicles exhibit stem cell properties and can form different cells types if they are given specific biological signals without the need to genetically modify the cells.

"Development of innovative tools for marine ecological assessment and intertidal habitat restoration Year Two *Renewal, previous title ""Development of innovative tools for marine ecological assessment and intertidal habitat restoration."""

Contaminated sites assessment and remediation is an area of specialized services provided by Keystone Environmental. The technical challenge facing Keystone Environmental is to develop an innovative approach to provide effective contaminated sites services at rocky intertidal beaches in British Columbia. The rocky beaches of Howe Sound, impacted by effluents from pulp mills and mine acid rock drainage, have been studied and a significant body of historical data has been accumulated. Re-establishment of biodiversity after decrease of the contaminant input was very slow or minimal.

Peptide Antagonists of Transient Receptor Potential Vanilloid Type Calcium Channel (TRPV6) as a Potential Therapeutic Agent for Multiple Myeloma

Overexpression of the calcium channel – Transient receptor potential vanilloid type (TRPV6) occurs in many epithelial type cancers [4] and hematological malignancy such as leukemia [7]. However, no correlation of TRPV6 to the deadly bone marrow cancer, multiple myeloma, has been made so far. Recently, we have detected the strong expression of TRPV6 protein in the bone marrow of MM patients, and this interesting finding has led us to investigate the potential of TRPV6 as a therapeutic target for multiple myeloma in collaboration with Soricimed Biopharma Inc.

Development of innovative tools for marine ecological assessment and intertidal habitat restoration.

The current innovative research project has three objectives to address current deficiencies in contaminated sites assessment and remediation:

(1) To develop a rating system that defines the stages of recovery/impact at marine sites based on intertidal community structure and pollution tolerance/sensitivity/intolerance of resident species.

(2) To develop methodology for the assessment of environmental stress levels at marine sites that prevent natural recolonization of the area.

Correlation of Coronary and Myocardial Strain Profiles for Cardiac Resynchronization Therapy

Cardia Resynchronization Therapy (CRT) is aq pacing therapy used to reduce symptoms and mortality in patients with heart failure. It delivers a specialized pacing lead to the left ventricle (LV) through the coronary veins to re-synchronize the contraction of the heart when it has become delayed or desynchronous. However its benefit has proved to be dependent on the placement of this lead to regions where mechanical delay is maximal and does not have underlying myocardial scar. Medtronic Inc.

Molecular Profiling of Survivin in Different Human Cancers

Survivin, a member of the inhibitors of the apoptosis protein family, is involved in multiple critical pathways of cancer cell growth and survival. Because of its selective expression in cancer cells but not in normal adult tissues, survivin is an attractive target for different cancer treatments. Immunovaccine Inc. (IMV) has developed a therapeutic cancer vaccine, DPX-Survivac, targeting survivn-rich cancer cells. The description should also indicate.

Isolation, characterization and culture maintenance of stem cells from human hair follicle mesenchyme

Stem cells and other pluripotent cells are under active investigation for the development of new therapeutic treatments to regenerate and repair diseased and damaged tissues. Published studies indicate that some mesenchymal cells derived from adult human hair follicles exhibit stem cell properties and can form different cells types if they are given specific biological signals without the need to genetically modify the cells.

Non-Viral delivery of insulin and IL-10 to the intestine for immunotherapy for type 1 diabetes

There is increasing evidence suggesting a link exists between the gut immune system and several autoimmune diseases, including diabetes. The industrial partner of this project, enGene, has developed an effective non-viral based technology for the delivery of genes to the intestine. enGene has demonstrated the feasibility of delivering IL-10, which is an anti-inflammatory cytokine, to the intestine and showed therapeutic efficacy in inflammatory bowel disease.

Alteration of plant cell wall structure for improvement ofbiomass hydrolysis

Biobased products, mostly derived from plant biomass, have the potential to improve the sustainability of Canada’s natural resources and environmental quality while competing economically. Plant biomass, composed primarily of cell walls and modification of cell wall properties has the potential to improve biomass conversion to biobased products such as biofuels. Progress towards achieving this goal is currently impeded by a lack of knowledge of how cell walls are assembled and how their structure affects the processing of biomass.

Joining lifestyle and cognitive assessment with Fit Brains Trainer data: Can Fit Brains brain fitness apps tell us what a “smarter” lifestyle look like?

Rosetta Stone Canada collects user demographic and performance data from Fit Brains Trainer (brain fitness training games), Cognitive Assessment, and Lifestyle Assessment mobile apps. Data from the three apps can be linked and analyzed to answer research questions such as how lifestyle factors can influence brain training habits and outcome. This internship will: 1. Statistically explore raw data in Cognitive and Lifestyle Assessment databases 2. Statistically normalize data in Cognitive and Lifestyle Assessment databases 3.

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