Development of a 3D in vivo Metastasis Model

Recent developments in cancer treatment have greatly improved patient survival and quality of life; however, tumour cells that invade and migrate to vital organs, such as lung and brain, are very difficult to treat successfully. We will develop and validate a 3D in vivo zebrafish model that will allow us to inject human cancer cells into the yolk sac of the fish and monitor how invasive the cancer cells are. We will test the accuracy of the model by comparing cell behavior in the zebrafish to those in standard invasion assays.

Novel product and process development for berry powder productinusing enzyme technology

The research aims to develop new technology for production of nutritional berry powders with lower production cost and higher quality. The project will test the properties of the raw material and formulate new method for processing the sample for simpler and cost effective production process. With the outcome of this project, the partner organization will be able to sell high quality product and gain a higher profit margin. The intern will get an oppourtunity to implement the principles of fundamental science in an industrial framework.

Correlation of Coronary and Myocardial Strain Profiles for Cardiac Resynchronization Therapy Year Two

Throughout my Doctoral Studies I have used various approaches to evaluate and/or predict the behaviour of cardiovascular structures in the setting of acquired disease. These have been focussed on two key methodologies: insilico testing aimed at predicting functional responses to therapeutic intervention, such as mechano-electric Finite Element Method (FEM) modelling of the left atrium strains and stresses in response to hypertension, and fluiddynamic FEM modelling of abdominal aortic aneurysms.

Simplified Identification of Insects using Software Tools and Digital Photography

Identification of insect prey is essential for understanding the foraging behaviours of insectivorous bat and bird predators. The intern will develop software tools that will aid a skilled entomologist with the rapid identification of insects from photographs taken from field collecting sites.

Visualisation et quantification des ROS et de l’apoptose dans des microtumeurs 3D

L’objectif du projet est de mettre au point des méthodes de visualisation par microscopie confocale laser l’intensité du stress oxydant ainsi que les zones d’induction d’apoptose dans des cellules cancéreuses perméabilisées. Les cellules cancéreuses qui seront étudiées sont des cellules de carcinome colorectal humaines de la lignée HCT116 provenant de American Type Culture Collection.

Evolutionary Significance of Hybrid Zones on Avian Biodiversity from the Neotropics

Tropical forests house an exceptionally high biological diversity and despite great interest in factors that might drive the formation of high species richness, little is understood about how this diversity arose. In the Neotropics, rivers appear to delimit the geographic ranges of closely related avian species, and are generally believed to have been important in in promoting species formation by acting as dispersal barriers to populations on either side.

Biomolecular Structure Analysis to Accelerate Development of New Vaccines and Monoclonal Antibodies

Manufacturing of consistently high quality products is the commitment of pharmaceutical industry. To achieve this, new products must be thoroughly tested and the results meet government-approved product specifications. Improving existing and adopting improved analytical technologies for product testing ensure the production of safe and effective products. This is particularly critical for the manufacturing of biologic products which, relative to small molecular drugs, have a larger size, are more complex in structure and are thus more difficult to characterize.

Violacein effects in mice Rho 264.7 cells

Violacein is a molecule naturally produced in some bacteria such as Chromobacterium violaceum. It has been shown that violacein has promising antibiotic, anti-tumor proliferation, anti-leishmanial and anti-fungal properties. Violacein is commercially available. However, it is very expensive. The objective of this proposed research study is to measure the effects of violacein produced by Escherichia coli on mice Rho 264.7 cells. Over a four month period the intern will use biotechnology techniques to accomplish the objective of this project.

Improvement of Quality and Efficacy of Natural HealthProducts & Dietary Supplement

The overall goal of this project is for the University science team at the University of Ottawa and University of New Brunswick to develop high quality Echinacea products for Canadian and world markets in collaboration with Amway Canada. One objective involves phytochemical and pharmacological selection and propagation of elite Echinacea from the historic Echinacea germplasm available at Amway’s Trout Lake Farm. A second objective is to develop evidence based marketing information on the improved Echinacea.

Assessing marine mammal presence in and near the FORCE Lease Area during winter and early spring – addressing baseline data gaps and sensor performance

The collection of baseline data on marine mammal use of tidal energy sites prior to Tidal In stream Energy Conversion (TISEC) deployments is considered vital in any subsequent post-deployment assessment of changes in marine mammal activity levels or spatial use. The proposed project involves the deployment of passive acoustic monitoring (PAM) devices (hydrophones) for an assessment of marine mammal presence in the Minas Passage and FORCE test area during the winter and early spring period of 2013/2014.

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