The Rise of Fishes: A Comprehensive Analysis of Fossil Evidence for the Origin and Early Evolution of Vertebrates

The origin and early evolution of vertebrates — fishes and their descendants — represents a poorly understood phase in the deep-time ancestry of the human lineage. A series of transitions occurred between 500 and 400 million years ago from a worm-like ancestor to a bony predatory

Functional genomics of abiotic stress tolerance in the brown algalmodel Ectocarpus siliculosus using an Arabidopsis toolbox

A Ph.D. student will be trained in an interdisciplinary area of algal functional genomics and molecular plant physiology. Combining these two areas in this project will solve two major issues. (1) Currently, there is a limitation in the study of brown algal functional genomics; brown algae, including Ectocarpus, are not yet amenable for genetic transformation, and other genetic tools like RNA interference system are still in their infancy for these organisms.

Biomonitoring 2.0 in Practice: Application of Next-Generation Sequencing to Biomonitoring for Use by the Environmental Consulting Industry

Canada is a world leader in both cutting-edge, DNA-based environmental research and in the abundance and variety of our natural resources. By bringing the transformative power of the "Biomonitoring 2.0" approach for use in the environmental consulting industry, I propose to take the best of the former and use it to create innovative methods for the most sustainable utilization of the latter.

Bioremediation potential of a bacterial inoculant, Inocul-M consortium, on switchgrass (Panicum virgatum L.) plants grown in soils amended with biochar and spiked with polycyclic aromatic hydrocarbons.

Remediation and reclamation of contaminated lands could be achieved by incorporating biofuel agro-ecosystems that utilizes large biomass plant species with low-nitrogen requirements and have high bioremediation potential, such as switchgrass (Panicum virgatum L.), in conjunction with biochar, a carbon–rich soil amendment, and inoculated with beneficial plant and soil microbes.

Farm to Fork: DNA traceability of poultry meat in North America

In the recent years, the concern for food safety and quality has been on the increase. This concern is escalated by media reports of food alteration, which in turn reduces the consumers’ confidence in food safety and the reliability of labelling. As such, traceability in agricultural/food chain is an essential tool to increase consumers’ trust. Although various traceability systems are currently in place, challenges exist in maintaining farm to fork traceability, thereby highlighting the need for development of reliable tools for food analysis.

Combatting oil reservoir souring through a predictive understanding of the ecophysiologyand functional diversity of nitrate-reducing bacteria

Oil reservoir souring is the production of toxic hydrogen sulfide by sulfate-reducing microorganisms (SRM) through naerobic respiration supported by organic electron donors present in oil fields. In recent years, nitrate injection has merged as a promising green biotechnology that has been proven effective in controlling sulfide production in oil fields. This strategy relies on inducing nitrate-reducing bacteria (NRB), which can outcompete SRM for organic lectron donors.

Isolation, characterization and culture maintenance of stem cells from human hair follicle mesenchyme Year Two

Stem cells and other pluripotent cells are under active investigation for the development of new therapeutic treatments to regenerate and repair diseased and damaged tissues. Published studies indicate that some mesenchymal cells derived from adult human hair follicles exhibit stem cell properties and can form different cells types if they are given specific biological signals without the need to genetically modify the cells.

"Development of innovative tools for marine ecological assessment and intertidal habitat restoration Year Two *Renewal, previous title ""Development of innovative tools for marine ecological assessment and intertidal habitat restoration."""

Contaminated sites assessment and remediation is an area of specialized services provided by Keystone Environmental. The technical challenge facing Keystone Environmental is to develop an innovative approach to provide effective contaminated sites services at rocky intertidal beaches in British Columbia. The rocky beaches of Howe Sound, impacted by effluents from pulp mills and mine acid rock drainage, have been studied and a significant body of historical data has been accumulated. Re-establishment of biodiversity after decrease of the contaminant input was very slow or minimal.

Peptide Antagonists of Transient Receptor Potential Vanilloid Type Calcium Channel (TRPV6) as a Potential Therapeutic Agent for Multiple Myeloma

Overexpression of the calcium channel – Transient receptor potential vanilloid type (TRPV6) occurs in many epithelial type cancers [4] and hematological malignancy such as leukemia [7]. However, no correlation of TRPV6 to the deadly bone marrow cancer, multiple myeloma, has been made so far. Recently, we have detected the strong expression of TRPV6 protein in the bone marrow of MM patients, and this interesting finding has led us to investigate the potential of TRPV6 as a therapeutic target for multiple myeloma in collaboration with Soricimed Biopharma Inc.

Development of innovative tools for marine ecological assessment and intertidal habitat restoration.

The current innovative research project has three objectives to address current deficiencies in contaminated sites assessment and remediation:

(1) To develop a rating system that defines the stages of recovery/impact at marine sites based on intertidal community structure and pollution tolerance/sensitivity/intolerance of resident species.

(2) To develop methodology for the assessment of environmental stress levels at marine sites that prevent natural recolonization of the area.