Phenols-Functionalized Single-Walled Carbon Nanotubes as a New Class of Antioxidants for the Prevention of Degenerative Diseases

The present project proposes a new type of antioxidant drug as a way to reduce genetically the probability of appearance of degenerative diseases, e.g. different cancers, Alzheimer’s disease and Atherosclerosis. The general idea is to combine two different types of compounds with antioxidant properties: nanomaterials and certain molecules extracted from a cuban plant with the goal to enhance their biological properties. In other words: if we combine two antioxidants in one, the resultant is even better. To design these new drugs we will use in principle computer modeling.

Development of a rapid, point of care, COVID-19 detection system using proximity-based electrochemical principles

Rapidly detecting SARS-CoV-2 in infected individuals remains a critical problem in Canada. The current detection method is hindered by the need for highly trained personnel and expensive laboratory equipment. Such requirements cause long wait times and reduce the ability to manage the spread of COVID-19 in our communities. This Mitacs Accelerate project aims at addressing such problems, i.e., developing a rapid, easy-to-use, point of care (POC) detection system for hospitals, airports, long-term care facilities and working places.

Exploration of Hydrogen Silsesquioxane (HSQ) Formulations and the use of HSQ as a Precursor for Silicon Quantum Dots for Use in Polymer Coatings

The project will entail the production and characterization of hydrogen silsesquioxane (HSQ), a useful material for both lithography and production of silicon nanomaterials. This material is the workhorse for Applied Quantum Materials Inc. (AQM), as it is one of their central products that they supply to the e-beam lithography industry as well as the precursor for their silicon nanomaterials.

Non-thermal sono-treatment improves the liquefaction and saccharification process and presence of phytochemicals of Cannabis sativa

In beer manufacturing, the liquefaction and saccharification process utilizes heat, alkaline and acid washes to break down complex sugars into wort (simple sugars) leading to destruction of desirable bioactive compounds. Beer manufacturers are keen to use green technology and non-starch plant materials from agri-food by-products. Province Brands has developed its proprietary methods for brewing from cannabis plant waste (stems, stalks, roots).

Genes to affordable medicines - Stream 1-A2

The Structural Genomics Consortium (SGC) is a not-for-profit public-private partnership research organization that aims to accelerate the discovery of new medicines through open science. This Mitacs cluster will bring together SGC’s industry and academic collaborators to work together towards new and affordable medicines for challenging diseases. Sixty-three post-doctoral fellows will spend 2-3 years developing open source tools and knowledge for previously understudied proteins, thereby unlocking new areas of biology and identifying new opportunities for drug discovery.

New electrolyte design for Li-ion batteries based on metal-based anodes

Lithium-ion batteries (LIBs), as a promising method for energy storage, have been widely used in our daily lives, and the boosting development of electric vehicles and electronic devices requires LIBs with a higher operation voltage. However, their safety problems are always a threat because of the unstable Li salt and flammable organic solvents in the commercialized electrolytes.

Development of a Quantitative and Inexpensive Opioid Detector for Clinical Use

The opioid epidemic is a serious health crisis and opioid treatment strategies are at the forefront of efforts to tackle this crisis. Replacement therapy is the current approach taken using medications such as methadone. To be more effective, the dosage needs to be tailored to individual tolerance which requires a point-of-care type analytical measurement of the patient's existing opioid level.

Development of new methods for screening bioilogics by means of Capillary Electrophoresis (CE) coupled with Mass-Spectrometer (MS) via novel Open Port Probe Sampling Interface (OPP)

The methods for screening complex biological samples found wide application in pharmaceutics, forensic science and medical science. The majority of these methods involve several analytical techniques coupled together in order to maximize the efficiency of the analysis. For example, the combination of Capillary Electrophoresis (CE) with Mass Spectrometry (MS) creates a new analytical platform (CE-MS) that utilizes the separation power of CE and superior detection abilities of MS.

Bio-based Latexes using Switchable Hydrophilicity Solvent (SHS)

The proposal focuses on the design and synthesis of novel bio-based, biodegradable materials to be used in packaging and protective coatings (varnishes), and targeted at replacing the nonrenewable, non- biodegradable materials currently used to manufacture these products. Our new process allows us to obtain a desired combination of material properties, and also eliminates the need for using VOCs (Volatile Organic Compounds). We achieve this using a new type of solvent whose properties can be “switched” simply by introducing or removing CO2 into or from the mixture.

Next-Generation Coating Materials for Architectural Lighting

Architectural and decorative lighting have significant impacts on our daily lives, especially our moods and mental health. We propose to combine supramolecular chemistry and cellulose nanocrystal gels, two intriguing research field in chemistry and material sciences, in order to develop the next-generation coating materials for architectural lighting. Such gel materials have the ability to change color and pattern spontaneously over time, which can be programmed or customized.