Development of Advanced Battery Materials for Longer Life, Higher Energy Density Lithium Ion Batteries

As lithium-ion batteries continue to expand in use, new applications such as electric vehicles have increasing demands for higher energy density and longer life batteries. Improvements beyond the industry standards will be achieved using new, innovative materials that will result in increased performance. Through this project, the intern will work on synthesis and processing new anode and cathode materials and work to demonstrate improved performance of those materials in full Li-ion batteries.

Characterization of Carotenogenic Heterotrophs for Production of High-Value Antioxidants

The development of novel biotechnologies will be a key component of the economic growth and development of Canada’s changing economy. A critical component of this will be fostering the development of start-up companies that can capitalize on these new opportunities. The Myera Group is an indigenous-led company in Manitoba that is developing novel biotechnologies for Canada’s new economy. This project focuses on the development of microorganisms that can produce a profile of novel high-value carotenoids (chemically related to ?-carotene).

Improving the properties of active pharmaceutical ingredients by polymorph, salt and cocrystal screening

Solids exist as crystals, amorphous or subcooled liquids. The degree of crystallinity determines the long range order in a solid phase. Molecules when transferred from the solution to the solid phase may take many different crystal forms (polymorphs, solvates/hydrates, salts, co-crystals). Theoretically, there are 230 space groups describing the diversity of a crystalline material. About two thirds of pharmaceutical small molecules exist in more than one polymorphic solid form. Crystallization of polymorphs still has a touch of art.

Hydrorefined fuels - computational insight into the mechanism

Improving the quality of fuels, increasing the efficiency and also producing lower emissions is one of the main challenges of the 21st century. A Calgary company, Katal, is working on a hydrorefining process in order to produce diesel fuel with superior quality compared with the traditional fuel. The company, however, has limited scientific understanding of the current process and also needs to possess further insights to make the process more efficient. This project will help to better understand the hydrorefining process and improve the properties of diesel fuel.

Generation and characterization of novel small molecule protein degraders in oncology

Many patients who initially respond well to highly efficacious chemotherapy eventually develop resistance and relapse despite continued treatment. These cancers acquire drug resistance to current therapies through various mechanisms such as the acquisition of mutations for example. Furthermore, some promising targets that play a crucial role in the progression of cancer have been deemed undruggable using current methods.

Advanced differential mobility mass spectrometry with electron capture dissociation for the characterization of therapeutic proteins - Year two

Many new pharmaceuticals are based on large biomolecules like proteins. Even small differences in the protein structure can cause significant changes in the efficacy and safety of these drugs. Furthermore, these large molecules are difficult to characterize without advanced instrumentation and methods. Current technologies still struggle with robustness and reproducibility. This study aims to introduce new technology to improve the reliability of protein pharmaceutical characterization.

Development of compact enhanced nebulization systems for inductively coupled plasma spectrometry

The measurement of toxins, such as arsenic, mercury, cadmium, lead and chromium for example, in food, beverages, environmental samples, waters, etc. must be carried out to verify that there is no danger. This requires analyses of numerous samples each day using instruments that can measure the small amounts that may be present.

Green Chemistry for Green Solvents

This project focuses on the development of new solvents, to replace those that are currently used in industrial processes. Currently, the majority of solvents used in industry are harmful to both people and the environment. These solvents are full of volatile organic compounds, which are released to the atmosphere and contribute to smog formation. Globally, smog is a major risk factor for human health, following only malnutrition, dietary risks, high blood pressure, and tobacco.

Synthesis of diamond and diamond-like films

This project is geared towards the development of a cost-effective method to fabricate thin films of carbon materials, such as diamond. The idea is to use solution-based methods coupled to electrochemistry to produce the films. Avenues for the deposition of the film on surfaces of arbitrary shapes will also be explored.

Development of new classes of bio-relevant linkers for PROTACs and other conjugates using new technologies - Year two

Les PROTACs sont de nouvelles molécules thérapeutiques ayant pour but de soigner certaines maladies grave comme les cancers. Ces composés sont des molécules linéaires constitués de trois composants principaux : une extrémité permettant de repérer la cible, une autre extrémité permettant de causer la dégradation de cette cible, et enfin un linker reliant les deux. Cette dernière partie est la moins étudié, bien qu’il ait récemment été prouvé qu’elle joue grandement sur les propriétés de la molécule finale.

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