Development of chemically modified probes for robust molecular diagnostics

The COVID-19 pandemic has highlighted the public need for molecular diagnostic tools to identify pathogen panels through nucleic acid amplification tests (NAAT). Many clinical labs worldwide have now established infrastructures for routine molecular assays using classic quantitative PCR (qPCR). In order to further advance this – now routine – tool for in vitro diagnostics (IVD), it has become imperative to develop underlying technologies for robust, specific, and sensitive detection of pathogens, namely next-generation oligonucleotide probes.

A sustainable electrochemical process for elimination of synthetic microfibers

Humans ingest over 50,0000 microplastic-particles every year. The main contributor to microplastic contamination is synthetic-fiber. One lo laundry load can release an average of 700,000 microplastic fibers. Wastewater treatment plants cannot catch all these microfibers, so they end in the oceans. New regulations, which require washing machine manufactures to implement microfiber filtration system are going to start on 2024. Viridis is a cleantech company addressing urgent global water pollution challenges from microplastics to harmful contaminants by eliminating them from water.

Discovery of Novel Inhibitors to Mitigate Morphogen NODAL-mediated Proliferation of Cancer Cells using a Novel Genetically-encoded Bicyclic Peptide Ligand as Reference.

The proposed project will focus on discovering novel drug candidates as a targeted therapy for cancer using computational and synthetic approaches. 48Hour Discovery INC (48HD) aims to build a high-value drug discovery platform for internal drug discovery programs and for clients that provide synthetic molecules with drug-like properties to maximize the success of early drug discovery efforts. 48HD has developed genetically-encoded technologies that accelerate drug discovery to find new and better drug candidates.

New Generation Membrane Electrode Assembly using Novel Nanoporous Carbon Scaffold

Hydrogen fuel cells (HFCs) are clean and efficient energy conversion devices that produce electricity from green hydrogen with zero carbon emissions. Currently, the catalyst layers in HFCs are composed of Pt-decorated carbon powders mixed with an ion conducting polymer (ionomer), leading to uncontrolled distribution of each phase and significant tortuosity due to the complex pores and pathways between particles. The membrane electrode assembly (MEA) is the core component of a HFC that plays the most critical role in the HFC performance and lifetime.

Protein profiling of blood samples of patients with mild traumatic brain injury

Mild traumatic brain injury (mTBI) and sports-related concussion have complex and variable neuronal pathophysiology. Despite extensive attempts for discovery and identification of protein biomarkers in the blood of concussion patients, the success of proteins markers is limited due to the heterogeneity and complexity of concussion. There are still no reliable protein biomarkers that can accurately diagnose sport-related concussion and to distinguish complicated and uncomplicated concussion.

Improvement of GC?GC-MS compound identification and development of multi-omics integration techniques using a clinical stool sample set

Multiomics studies of the human microbiome have an enormous potential for understanding the mechanism of biological processes involving the microbial community and the metabolites produced by gut microbiota. We will apply a multiomics strategy to clinical fecal samples using a novel collection device to stabilize fecal metabolites at room temperature, thereby making the standard practise of freezing at - 80°C unnecessary.

Implementation of Quantum Simulation Algorithms for Research and Industry

In 1982 theoretical physicist Richard Feynman stated, “Nature isn’t classical … and if you want to make a simulation of nature, you’d better make it quantum mechanical”. The goal of this Mitacs internship project is to do just that. This project focuses on simulating quantum systems on a quantum computer – a new kind of computer that operates using the physics of quantum mechanics. There has been much progress in the development of algorithms for simulating quantum mechanics on a quantum computer, yet in practice there aren’t much of these algorithms that have been implemented.

Synthesis and characterization of a new generation of bone targeting anabolic and anti-cancer prodrugs

This project is intended to discover new drugs to treat bone diseases. Getting drugs too bone is very difficult due to poor vascularization of bones and require high doses of a potent drug which can lead to unacceptable side effects. This project intends to design, synthesize and characterize novel “bone-targeting prodrugs” to treat osteoporosis, help repair bone fractures and injuries and to treat bone cancers. These prodrugs will bind selectively to bones and then slowly release the active drugs over days and weeks so as to provide enhanced efficacy and reduced side effects.

Monitoring of Multiclass Organic Pollutants in Waters by Use of Thin-Film Microextraction (TFME) Coupled with Comprehensive Two-dimensional Gas Chromatography Time-of-flight Mass spectrometry (GCxGC-TOFMS)

Organic compounds in water can be potentially hazardous. We will develop a green and solvent-free method for screening the organic pollutants in different water samples. Also, we will study the changes in water during the different treatment process. This research will benefit the community and provide a protection protocol.

Influence of Chemical Dyes on Polyethylene Terephthalate Polymerization

This project seeks to examine how impurities affect the polymerization kinetics of recycled polyester monomers. The textile industry used over 50 million tons of polyester fibers made from polyethylene terephthalate (PET) annually.1 Because polyester fibers are slow to degrade, waste textiles have accumulated in landfill and natural environments, causing near-permanent land contamination.2 The ability to recycle polyester fibers is, therefore, essential to the responsible use of textiles and environment stewardship.