Synthesis of Three Minor Cannabinoids

The recent legalization of marijuana across the globe has sparked new interest in studying the health benefits of non-psychotropic cannabinoids. The majority of the studies have revolved around cannabidiol as it can readily be isolated in high quantities from hemp. Preliminary medicinal studies into CBD have revealed its promise as a treatment for anxiety, and chronic pain. Encouraged by this success, investigations are now shifting to the minor cannabinoids.

Hyperpolarized 129Xe Cerebral Perfusion MRI Imaging Development - Year two

Imaging of cerebral perfusion (the delivery of blood to a capillary bed in the brain tissue) is significant for diagnosing a variety of diseases. There are multiple challenges associated with perfusion imaging which significantly limits the quality of cerebral perfusion images. I am planning to develop a novel approach of cerebral perfusion magnetic resonance imaging (MRI) using hyperpolarized (HP) xenon-129 (129Xe). To conduct HP 129Xe perfusion imaging, I am developing a novel HP MRI Time-of-Flight (TOF) pulse sequence.

Synthesis of glycopolymers by in vacuo glycation

Sugars play many important roles in our bodies. For example, they provide a supporting environment around cells and are also involved numerous processes, including viral and bacterial infection. In addition to their natural existence, there is also interest in preparing sugar-based polymers, called “glycopolymers”, in the lab both to better understand biological processes and also to develop potential therapeutics. However, most methods to prepare these molecules are costly and time consuming.

Development of test strips for early identification of buddy maple syrup

Near the end of every maple syrup harvest season, the syrup can acquire an unpalatable off-flavour called ?buddy?. Buddy flavor cannot be detected in the maple sap prior to processing into syrup, often resulting in loss of income, and unnecessary cost in materials to produce the syrup. This proposal seeks to develop a low-cost field test to be used by maple syrup producers for the detection of compounds that are linked to the development of the buddy flavor. This will be accomplished by developing special receptors, known as aptamers, for these compounds.

Improving cycle life of Tin-based anodes in Li-ion batteries

The next generation metal-based anodes will play a decisive role in the development of not only Lithium-ion batteries, but also the renewable energy sector. This research project is anticipated to improve the cycle life of existing Tin-based anodes and bring them one step closer to commercialization. Our objective is to identify, isolate, and mitigate factors that decrease the cycle life of metal-based anodes, and improve the cycle life by modifying the anode structure. The success of this project will accelerate the technology commercialization of the partner organization.

Solid-state Li batteries with high-capacity electrodes and composite electrolytes

Lithium-ion batteries have a profound success in electric vehicles, portable electronics, and many other energy storage applications. However, explosion accidents frequently occur worldwide due to the flammable electrolytes inside. Superionics Inc. is aiming at solving the safety hazard of Li-based batteries. In this project, HQPs will develop non-flammable composite electrolytes, that can fundamentally eliminate the combustion risk. They will also work on high-capacity electrode materials that can couple with composite solid electrolyte.

Reformulation of Electrochemical Sensors for Trace Dissolved Oxygen Monitoring

Electrochemical sensors for monitoring dissolved oxygen levels are commonplace in industrial, researchand regulatory labs. The industrial partner?s commercialized device is capable of real-time monitoring ofO2 at parts-per-billion levels but is interested in reformulating the electrode materials to remove heavymetals, thereby minimizing negative environmental impact and ensuring sustainability of the technology.This project will measure and document the characteristics of candidates to replace the heavy metals inthe electrodes while ensuring continued operation at necessary.

Development of Mass Spectrometry Methods for Global Tissue Metabolome Analysis

Metabolomics is a rapidly growing field involved in detecting and characterizing all the metabolites present in a biological system such as blood, urine, cells and tissues. Metabolomics has been increasingly used in many different areas of applications, including the discovery of metabolite biomarkers for early diagnosis or prognosis of diseases, holistic study of biological systems (often in combination with genomics and proteomics), developing improved strains of crops or plants for increasing yields with higher tolerance to cold and resistance to drought or insect pests, etc.

Silicon Nanoparticle and Cellulose Nanocrystal Reinforced Polymer Composites

Cellulose and Silicon are two of the most abundant natural materials in the world, thus it is only “natural” to combine the two materials. Specifically, cellulose nanocrystals (CNCs) have been attractive sustainable additives for the mechanical reinforcement of polymers and silicon can be easily converted to silicon nanoparticles (SiNPs) for use in biosensing, coatings, and used as quantum dots in optical films, and medical and display applications.

Developing a Sensitive and Quantitative Opioid Detector for Use in a Clinical Setting

The opioid epidemic is a serious health crisis in Canada, North America, and globally and has worsened during the COVID pandemic. Opioid treatment strategies are at the forefront of efforts to tackle this crisis. To improve the replacement therapy currently used, an estimate of tolerance is required. This proposal takes an existing proof-of-concept opioid detection device and adapts it for use in the clinical setting to address this challenge.