New Generation Membrane Electrode Assembly using Novel Nanoporous Carbon Scaffold

Hydrogen fuel cells (HFCs) are clean and efficient energy conversion devices that produce electricity from green hydrogen with zero carbon emissions. Currently, the catalyst layers in HFCs are composed of Pt-decorated carbon powders mixed with an ion conducting polymer (ionomer), leading to uncontrolled distribution of each phase and significant tortuosity due to the complex pores and pathways between particles. The membrane electrode assembly (MEA) is the core component of a HFC that plays the most critical role in the HFC performance and lifetime.

Protein profiling of blood samples of patients with mild traumatic brain injury

Mild traumatic brain injury (mTBI) and sports-related concussion have complex and variable neuronal pathophysiology. Despite extensive attempts for discovery and identification of protein biomarkers in the blood of concussion patients, the success of proteins markers is limited due to the heterogeneity and complexity of concussion. There are still no reliable protein biomarkers that can accurately diagnose sport-related concussion and to distinguish complicated and uncomplicated concussion.

Improvement of GC?GC-MS compound identification and development of multi-omics integration techniques using a clinical stool sample set

Multiomics studies of the human microbiome have an enormous potential for understanding the mechanism of biological processes involving the microbial community and the metabolites produced by gut microbiota. We will apply a multiomics strategy to clinical fecal samples using a novel collection device to stabilize fecal metabolites at room temperature, thereby making the standard practise of freezing at - 80°C unnecessary.

Implementation of Quantum Simulation Algorithms for Research and Industry

In 1982 theoretical physicist Richard Feynman stated, “Nature isn’t classical … and if you want to make a simulation of nature, you’d better make it quantum mechanical”. The goal of this Mitacs internship project is to do just that. This project focuses on simulating quantum systems on a quantum computer – a new kind of computer that operates using the physics of quantum mechanics. There has been much progress in the development of algorithms for simulating quantum mechanics on a quantum computer, yet in practice there aren’t much of these algorithms that have been implemented.

Synthesis and characterization of a new generation of bone targeting anabolic and anti-cancer prodrugs

This project is intended to discover new drugs to treat bone diseases. Getting drugs too bone is very difficult due to poor vascularization of bones and require high doses of a potent drug which can lead to unacceptable side effects. This project intends to design, synthesize and characterize novel “bone-targeting prodrugs” to treat osteoporosis, help repair bone fractures and injuries and to treat bone cancers. These prodrugs will bind selectively to bones and then slowly release the active drugs over days and weeks so as to provide enhanced efficacy and reduced side effects.

Monitoring of Multiclass Organic Pollutants in Waters by Use of Thin-Film Microextraction (TFME) Coupled with Comprehensive Two-dimensional Gas Chromatography Time-of-flight Mass spectrometry (GCxGC-TOFMS)

Organic compounds in water can be potentially hazardous. We will develop a green and solvent-free method for screening the organic pollutants in different water samples. Also, we will study the changes in water during the different treatment process. This research will benefit the community and provide a protection protocol.

Influence of Chemical Dyes on Polyethylene Terephthalate Polymerization

This project seeks to examine how impurities affect the polymerization kinetics of recycled polyester monomers. The textile industry used over 50 million tons of polyester fibers made from polyethylene terephthalate (PET) annually.1 Because polyester fibers are slow to degrade, waste textiles have accumulated in landfill and natural environments, causing near-permanent land contamination.2 The ability to recycle polyester fibers is, therefore, essential to the responsible use of textiles and environment stewardship.

Hybrid Quantum-Classical Algorithms for Fuel Cell Optimization

Hydrogen fuel cells represent one of the most exciting technologies available for producing clean energy for onsite combined heat and power delivery, portable electronics, and electric vehicles. In the transportation sector specifically, several commercial vehicles powered by hydrogen have hit the market in the last several years, on top of a growing number of city buses and cargo trucks running on fuel cells. However, high cost due to the use of the precious metal platinum remains a barrier to their widespread adoption.

Generation of small molecule from pharmaceuticals waste via thermochemical conversation

In the shadow of a worldwide pandemic, the importance and need for pharmaceutical research is abundantly clear. In Canada alone, 25 billion units of pharmaceuticals are dispensed every year, and of that 30% of the total product ends up as waste, about 1.1 million kilograms per year. How these pharmaceuticals are wasted has impacts both economically and environmentally. Thermochemical conversion is a method to thermally decompose the waste pharmaceuticals in order to convert them into high value added materials. This process leads to obtain a carbon based material called char and a rich oil.

Analysis of proteome dynamics in single cell reprogramming proceeds

The ability to revert human cells back into a stem cell state, and then reprogram them into new cell fates has unlocked promise for future regenerative therapies. However, we still do not fully understand this reprogramming process and the interaction of proteins that make this happen. Mass spectrometry (or MS; a common technique to study molecules using a mass-to-charge ratio) may allow us to identify these unknowns but would require the collection of a large number of cells undergoing identical stages of reprogramming – a feat that is not experimentally practical or feasible.