Portable diagnostic device for outpatient BNP detection

Brain natriuretic peptide (BNP) is an established prognostic marker for the early detection of heart failure. Elevated blood BNP levels are directly correlated to the severity of HF and decompensation. Current FDA approved immunoassays for BNP detection can only be carried out in medical laboratories or emergency rooms. Outpatient-use BNP monitors are yet to be developed. The objective of this project is to develop a prototype of the portable diagnostic device that can give a rapid electrical readout of BNP levels in a drop of blood.

The development of DPIS and associated dopant chemistry for use in standalone IMS systems

Scintrex Trace Corp. is a company that designs and manufactures systems that detect trace amounts of explosives, narcotics, and other chemicals. Due to the economic and regulatory challenges facing their current systems, they want to develop a new system that can better detect these chemicals without the regulatory and economic burdens. Scintrex is partnering with Professor Jeffrey Smith at Carleton University, and expert in the field of chemical spectroscopy, to develop a new trace detection system.

Nanostructured Nickel Materials for Clean and Renewable Energy

With the rising concern regarding environmental pollution and greenhouse gases, the demand for clean and renewable energy sources has never been greater. Recent developments in fuel cell technology have been promising; however, these fuel cells may be unsuited for mass production due to the prohibitive cost of the platinum-group metal nanoparticles which are required as electrocatalysts. Thus, there is a pressing need for improvements to fuel cell technology such that they require much less platinum metal.

Glycoprofiling of Erythropoietin using High Resolution Capillary Electrophoresis-Mass Spectrometry

Erythropoietin is a protein with attached sugars that stimulates the production of red blood cells. As such, it can be used by athletes to enhance their competitive performance, an act that is called doping. Erythropoietin that us used for doping is typically produced in animal cells, which functionalize the protein with sugars that differ from those produced in human cells.

Optical determination of membrane defects and correlation with fuel cell performance and durability

There is a strong push toward producing fuel cells on a commercial scale. This means a greater focus on production speed and yields with a need to understand the unintended features that arise from larger-scale manufacturing processes. This project requires the set up of state-of-the-art, camera-vision, defect detection equipment to find and collect observed membrane features. These features will then be catalogued and tested to determine their impact on membrane durability and whether they affect later processing steps.

Determination of peanut allergen in foods using a dual fluorescence-SERS immunoassay

Peanut is one of the leading foods that can cause food allergies. An extremely low amount of peanut protein is sufficient to cause mild reactions in people who are sensitive to peanut. Over 90% of allergic reaction cases derived from peanut digestion are related to Ara h 1, a glycoprotein that comprises about 15% of the total protein content in peanut and are not degraded during food processing. In this project, we aim to develop a dual fluorescence-SERS immunoassay using graphene quantum dot labeling on aligned magnetoplasmonic nanowires.

Doubly-resonant sum frequency generation studies of rhodamine 6G films

The potential for solar cells as renewable energy sources is increasingly recognized as better devices come to the market. It has been recognized that the use of organic dyes as sensitizers can greatly enhance their performance. As a result, there has been an increased effort to develop new dye-sensitized materials for more efficient light harvesting. In order to optimize the conversion of solar energy into electricity, the surface orientation and conformation of the dye is a critical aspect of its performance.

Photoredox Fluorination: Selectively Synthesize 2-fluoro-2-methyl-2-deoxyarabinolactone Derivatives via a Radical Pathway

Nature’s ability to convert solar energy to chemical energy in photosynthesis has inspired the development of a host of photoredox systems in efforts to mimic this process. The capacity of fluorine atoms to engender a variety of useful properties in pharmaceuticals, agrochemicals, and performance materials has driven significant research efforts toward the invention of novel fluorination reactions. We
proposed to construct C-F bonds by photoreodox catalysis via a radical pathway. Our project will bring potential benefit to academia and industry.

Chemically Modified Graphene-Like Carbon for Water Purification and Charge Storage Applications

This internship will focus on the chemical modification of a graphene-like material developed by 3M Canada towards membranes for the removal of divalent cations from water and chargestorage materials (supercapacitors). The need for improved purification technologies, specifically those that target the removal of divalent cations, such as calcium and magnesium, which are found in hard water, has never been greater due to the growth of our population and the related industrial and agricultural sectors of the Canadian economy.

Manganese Salen Systems for C-H Functionalization

Selective incorporation of valuable building blocks into feedstock chemicals is a very important, albeit often times difficult challenge. We plan to develop catalysts; materials to efficiently convert feedstock chemicals into ones with valuable functionality. The catalysts developed by the
current project will incorporate two traditional reactive sites as a means to enhance activity and selectivity of our selected transformations. Through various techniques we plan to interrogate the properties of our developed systems in order to inform decisions about second generation

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