Nano-varnish with integrated biomineralizable and antibacterial activity against dental caries

Dental caries is a major health hazard in the general population worldwide. Fluoride-based formulations are conventionally used to resolve this problem but they present certain important disadvantages, which has been overlooked. Here we propose to develop and characterize a non-fluoride based dental varnish using natural product conjugated nanoparticles that holds the potential of inhibiting bacterial plaque formation and repair early damage on tooth surface. The potential long-term benefits of this product are extensive and include prevention of dental caries and improved quality of life.

Optimization and validation of Aragonite-based toothpaste for dental calculus removal

Most of the available toothpastes are designed to manage tooth decay. Older individuals, however, suffer from gum diseases that caused by accumulation of plaque and tartar on teeth or implants.
The most common way of cleaning the teeth is with a brush and toothpaste. However, even though major companies offer a wide range of products to manage gum disease, they all have limitations when it comes to removal of tartar and cleaning dental implants.

Enhanced and Conformation Specific G protein-coupled receptors (GPCRs) Expression for Autoimmune Diagnostics

G protein-coupled receptors (GPCRs) are proteins present on the surface of a cell that are the targets of >30% prescription drugs. These GPCRs are involved in various diseases ranging from hypertension, airway diseases to taste disorders. Detection of antibodies for GPCRs in various disease states is a challenging task. The main goal of this project is to develop novel methods and improve existing methods to overexpress a couple of GPCRs for potential use in diagnostic assays. The industry partner, Acudex Inc.

Efficacy of antibacterial/antifungal mouth rinses in the control of periodontal pathogens and behaviour of neutrophils under these conditions

Periodontitis is a polymicrobial infectious and inflammatory disease that can lead to destruction of supporting structures of teeth. Although pathogenesis of periodontitis includes genetic and environmental factors, oral microbial biofilm elicits an inflammatory host reaction. Improvement in patients with periodontitis relies mainly on elimination or at least control of periodontal pathogens. The aim of this study is to investigate the activity of antibacterial-antifungal mouth rinses on growth and virulence properties of planktonic/biofilm cells of specific periodontal pathogens.

Fracture Toughness of All-Ceramic Crowns Luted with Different Cements.

Introduction: Computer-aided Design (CAD) computer-aided manufacturing (CAM) technology, all-ceramic systems, and high-strength ceramic materials have become integral parts of modern dentistry and laboratory technology.[1] Furthermore, metal-based crowns have other disadvantages, such as galvanic reaction, and the metal underlying the veneer’s porcelain can show through as a dark line.[2,3]
Several new all-ceramic systems, which offer comparable stability to porcelain-fused-to-metal (PFM) restorations, good esthetics, and simplified fabrication procedures, have been introduced.

3D Modeling of The Pancreas For Use in Preoperative Surgical Planning and Rehearsal

The graduate student (Simon Byrns) will work closely with pancreas surgeons and experts in computer image manipulation to generate 3D models of the relevant anatomy in pancreas surgery. These models will then be printed on a 3D printer and used to investigate their utility in the preoperative planning phase prior to surgery. The use of augmented reality (superimposing computer generated images on live images) to enhance the visualization of internal structures within the 3D models will also be investigated.

Human umbilical cord perivascular cells as cell therapeutics for biodefense and immunomodulation

Mesenchymal stromal / "stem" cells (MSCs) are found in adult tissues such as bone marrow and fat and also in neonatal tissues such as the placenta and umbilical cord. Among these sources, Human Umbilical Cord PeriVascular Cells (HUCPVCs) are the richest source of MSCs described. Importantly, they possess immunomodulatory and immuneprivileged properties which enable them to be delivered from one donor to another, evading immune detection. Tissue Regeneration Therapeutics (TRT) Inc.

Enhancement of the Performance of the Prefail’s Implant Health Monitoring System

This research and development project intends to improve the performance of a dental implant stability measurement (ISMS) device made by Prefail Dental Solutions Inc. The technical improvements proposed by this project includes (i) developing an impeoved and reliable signal processing technique, (ii) designing a calibration unit, (iii) designing a new tip for the ISMS clinical application, and (iv) fine-tuning the parameters in the quotient calculation algorithm of the ISMS.

Osteoinductive, osteogenic and angioinductive potential of intramuscular injected genetically modified human umbilical cord perivascular cells

The loss of bone is a massive burden on the health care system and severely impacts the quality of life of several hundred million people. The need for alternative strategies to replace or regenerate bone tissue is overwhelming. We are proposing a completely new approach to the engineering of bone using a “cocktail” of genetically modified human umbilical cord perivascular cells (HUCPVCs) that can be produced in vast numbers, stored in liquid nitrogen so that they could be ready for therapeutic purposes.

Cocktails of Different Populations of Genetically Modified Human Umbilical Cord Perivascular Cells for Bone Regeneration

The loss of bone is a massive burden on the health care system and severely impacts the quality of life of several hundred million people. The need for alternative strategies to replace or regenerate bone tissue is overwhelming. We are proposing a completely new approach to the engineering of bone using a ―cocktail‖ of genetically modified human umbilical cord perivascular cells (HUCPVCs) that can be produced in vast numbers, stored in liquid nitrogen so that they could be ready for therapeutic purposes.

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