Quantifying the oxidization of polysaccharides and optimizing dextran-bovine serum albumin glycation conditions for development of a new pneumococcal vaccine

Pneumonia remains the single leading cause of childhood death under age 5 worldwide. The price per dose of current vaccines is high and supply is limited due to a complex manufacturing process and low yield, significantly reducing its distribution in developing nations. A newly patented vacuo dry-glycation process promises much higher efficacy than the conjugation chemistry used currently, paving the way towards a much lower dosage cost. and its vaccine is a kind of polysaccharide-protein conjugate system.

Peptide-Functionalized Graphene Oxide Nanocarrier for Targeting Drug Delivery and Cancer Treatment

Carbon Upcycling Technologies Inc. is a technological research and development company in Calgary. They chemically adsorb carbon dioxide emissions into carbon-based materials, such as graphitic nanoplates and graphene oxide, and they commercialized the technology. Recently, extending graphene-based materials into drug delivery applications is attracted their attention. However, specific targeting and intracellular trafficking are the most important requirements in a well-performed drug delivery systems. Targeting molecules have to be attached to graphene-based materials.

Hybrid bacteriophage platforms for the production of non-invasive, self-adjuvanted, and targeted DNA vaccines against SARS-CoV-2

Our project aims to design and develop COVID19 vaccines engineered from viruses that infect bacterial cells only. SARS-CoV2 pathogenic components have been identified and modified to develop the vaccine. Although these components are pathogenic in nature, they are modified to pose no harm. The vaccine is designed to be administered intranasally, where it relocates to the lower respiratory tract. Upon reaching respiratory cells, the vaccine binds to respiratory cells and delivers the carried component. The delivered component will self-assemble into a SARS-CoV2 shape mimic.

Supercritical water gasification of bio-oils for synthetic jet fuel

Greenfield Global is currently developing a conversion process to produce jet fuel from renewable feedstocks. Collection and densification of different biomass waste materials and municipal waste at satellite facilities to produce bio-oils, which are then processed at a central facility, is expected. The first processing step at the central facility is supercritical water gasification and it is the focus of this project. The bio-oils are converted by supercritical water gasification to produce synthesis gas.

Production of semi-synthetic jet fuel

Greenfield Global is developing a process to produce jet fuel from renewable materials, such as waste biomass and organic municipal waste. The renewable materials are first converted to a synthetic oil and then converted into jet fuel. This project deals with the final step in the process, namely, to convert the synthetic oil to jet fuel. Jet fuel must meet stringent international specifications which makes it difficult to develop an alternative fuel for aviation.

Development of Welding Alloy Formula for Wear-Corrosion Resistant Overlay

There is a strong market demand for welding filler metals to make surfaces that can resist both abrasive wear and chemical loss. The objective of this internship is to quickly design and formulate high-chromium submerged arc welding powder for overlay. The experimental core for this project involves selecting alloys and designing microstructure at the University of Alberta, welding testing at sponsor Trimay facility, and wear and corrosion testing of produced overlay at a commercial lab.

State Estimation and Active Equalization of Lithium-ion Batteries for Application in Battery Management System (BMS) for Electric Vehicles

Electric vehicles (EVs) industry is a promising solution to address the oil crisis and environmental pollution. There are some challenges that limited the widespread adoption of EVs such as limited driving range, long charging time, and safety consideration. To tackle these challenges, the battery management system (BMS) in electric vehicles requires substantial improvement. For instance, accurate battery on-line state estimation in BMS, such as state of charge (SOC), state of health (SOH), and state of power (SOP) can enhance the reliability of EVs.

Process Analytical Tools, Flow Cytometry and Raman Analysis for Cell Viability Studies

The objective is to develop an in-line Process Analytical Technology (PAT) tool to monitor viability and biomass levels at the fermentation stage bacterial organisms.
The Master student will be engaged in the development of the PAT tool for deployment into a state-of-the-art vaccine manufacturing facility. The student will use benchtop tools such as flow cytometry to monitor the bacterial fermentation process and develop correlations to the inline measurements.

Development and Optimization of Immune-Evasive Capsules for Cell-based Therapies

Cell-based treatments for chronic metabolic disorders such as diabetes are poised to disrupt conventional treatments based on insulin administration through needles. These treatments involve transplanting cells that can provide the needed hormone or enzyme directly into the patients' circulation, in principle for years and without human intervention.
However, these transplanted cells need to be protected from immune recognition by the patients' immune system.

Studies on uptake and translocation of patented active ingredients in plants

The Suncor/McMaster partnership is generating a pipeline of novel, green, agricultural chemicals to be applied as crop sprays. One of the challenges with treating plants by spraying leaves (foliar treatment) is targeting the transport of the active ingredients (AI) to specific parts of the plant. An example is preventing bacterial growth in the xylem, channels that carry water from the roots up the plant.

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