Development and characterization of nano-emulsification and liposomal platforms (NEP and LIP) for hemp oil nanoencapsulation and transmucosal delivery

A novel technology for delivery of biologically active compounds found in hemp oil is being developed. This novel technology significantly reduces the health risks associated with traditional administration of Cannabis products (e.g., smoking and THC-related intoxication) The proposed project, in collaboration with a federally-licensed facility for cannabinoid analysis, Abattis Bioceuticals, engages into the development of two different platforms for encapsulation of hemp oil using nanoemulsion and nanolipid carrier technologies.

Condom Negotiation Among Gay, Bisexual, and Other Men Who Have Sex with Men

The aim of The Ontario HIV Treatment Network (OHTN) is to help combat the spread of HIV by supporting, conducting, and sharing the best research possible. This project will involve a novel analysis examining aspects of condom negotiation among gay and bisexual men who have sex with men (GBMSM). This work is needed because the HIV prevention methods that involve drug regimens are not available to all GBMSM and do not protect against the transmission of bacterial sexually transmitted infection (STIs).

Finding innovations to improve calf gastrointestinal health

The neonatal and pre-weaned periods are the most challenging in dairy production, resulting in the highest mortality and morbidity rates, with diarrhea proving the most common cause of calf health problems. In order to treat and control this diarrhea, producers often rely on antibiotic therapy. An alternative is to provide living microorganisms (probiotics) that minimize pathogenic bacteria colonization of the gastrointestinal tract (GIT), without producing drug residues, when directly fed to animals.

Evaluation of probiotic bacterial strains for enhanced microbial biotransformation of polyphenol-rich potato extract

The proposed project searches to understand the effect of probiotic bacterial strains belonging to the Lactobacillus and Bifidobacterium genera on the degradation and bioavailability of phenolic compounds present in potatoes (Solanum tuberosum L.) after in vitro digestion. The more easily absorbed metabolites are associated with protective effects against cancer and diabetes mellitus type II. Additionally, the combination of probiotics with phenolic-rich potato extract may have beneficial effects on the human colonic bacterial composition.

Bioactive peptides and joint inflammatory response after in vitro human digestion of collagen hydrolysate

Genacol Canada Corporation Inc. manufactures a bovine-sourced hydrolyzed collagen supplement (Genacol® Original Formula), which has shown efficacy in two separate clinical trials for reducing joint pain. Following digestion, hydrolyzed collagen yields amino acids and peptides that can lead to the health promoting properties of the supplement. However, the specific identity and mechanisms of action of the peptide and amino acids produced from the digestion of the Genacol collagen hydrolysate that support joint health is unclear.

Testing nutrient profiling tools and portion size based initiatives (education, regulation and reformulation) for public health policy in Canada

Poor diet is one of the factors associated with obesity and overweight, which may increase the risk for chronic diseases such as diabetes, heart disease and cancer. Two ways to improve the diets at the population level are to 1) establish public health initiatives (e.g.

Evaluation of botanical extract formulations for greenhouse pest management

The development of additional pesticides which minimize negative effects on the environment and beneficial insects is imperative for successful long-term management and enhanced sustainability of agricultural systems. Utilizing plant based essential oils, which generally have low toxicity to humans and other mammals, could increase sustainable pest management options.

NMR analysis of the enzymatically produced propylene glycol mono- and di- esters of canola oil

Emulsifiers as multifunctional additives can develop low-caloric, high-quality foods. Beside the monoacylglycerols (MAGs), or mixtures with diacylglycerols (DAGs), propylene glycol (1,2-propanediol) esters (PGEs) are the commonly used emulsifiers in the food industry. Emulsifiers are currently produced using costly and environmentally unfriendly “enzyme in solvent” systems and also have some shortcomings in certain food applications.

A survey of Pinot Noir Saccharomyces cerevisiae yeast populations and grape quality in three Okanagan Valley vineyard sub-regions

Wine is produced by fermenting sugars in grape juice to ethanol by the yeast Saccharomyces cerevisiae (S. cerevisiae). The major BC viticulture area is located in the Okanagan valley, a 200km region that runs from north to south, which aims to produce high quality wines that can be distinguished based on terroir. Terroir is a term that describes all the environmental factors that influence the wine including climate, terrain, soil, grape varietal and microbial populations.

Probiotics and their role in an intestinal inflammation: Use of a novel in-vitro model to understand mechanisms of action

In recent years, there has been a growing interest in the role the gut plays in our overall health and wellbeing. Changes to this gut microbial population has been linked a host of disorders, ranging from metabolic disorders such as diabetes and obesity to mental disorders such as depression and anxiety. Depending on lifestyle factors, diet, antibiotic use and age, certain populations can be at a greater risk of microbial imbalances. In order against such conditions, probiotics are used as therapeutic agents.