Recent publications have surveyed cannabis flower microbiological communities, detecting several concerning genera like Aspergillus spp., Penicillium spp. Clostridium, Eschericia, Salmonella and Staphyloccus. There are several documented cannabis complications and even fatalities due to Aspergillosis in immuno-compromised patients. One must also recognize that strict and nonspecific microbial regulations can eliminate the use of beneficial microorganisms in agriculture and deliver unforeseen consequences in the marketplace.