Rheumatoid arthritis (RA) is an autoimmune disease often characterized by the inflammation of the synovium and effusion of joints. RA is a chronic condition and may affect quality of life. Detection and characterization of the synovium and effusion in joints is most often assessed by a trained sonographer or radiologist. Recently ultrasound has been brought into the clinic and used by other trained healthcare professionals such as clinicians and physiotherapists.
Patients receive heart transplants as a life-saving measure after heart failure; thus, ensuring the success of the transplant is of utmost importance. Rejection is a primary cause for heart transplant failure, and consequently, patients must take drugs that suppress the immune system to prevent rejection. However, these drugs are highly unspecific and cause serious side effects that can be life-threatening. New immunosuppressive drugs that can prevent transplant rejection while allowing normal immune function can greatly improve care and patient outcomes.
The current workflow for COVID-19 testing is overwhelmed for many reasons including the need for time-consuming sample preparation, the limited availability of test reagent, and the length of time it takes to complete the test process (approximately 3 hours). As the test-and-trace approach is critical to containing the spread of this virus, rapid diagnostics are crucial. To improve the testing timeline, diagnostic labs need to process samples quickly, which requires the use of automated tests. The use of magnetic bead technology is highly amenable to automation.
Increased physical activity has been shown to be beneficial for people who experience infertility and obesity. However, limited research exists on exercise programs that help women improve their ability to conceive. Using the principles of exercise science, our research team will develop an exercise program for women experiencing infertility and obesity. Due to COVID-19, there has been a suspension in fertility services, highlighting the need for non-invasive treatment options that can be prescribed virtually.
Nutra Holdings Inc. is a nutritional supplement e-commerce company based in St.
The intern will undertake the development and evaluation of a novel gene-edited immune cell therapy for the treatment of different cancer types. The cancer immune cell therapy is a hot and rapidly growing field that has yielded success and clinically meaningful benefits for the treatment of certain cancers. Many of these successes have been with a kind of treatment called CAR T cells, which are potent anticancer cell therapies yet pose significant safety concerns, namely a potentially lethal inflammatory condition called cytokine release syndrome and neurological complications.
A newly identified group of cells termed type 2 innate lymphoid cells (ILC2s) have been discovered in the past decade. Increasing evidence supports the view that ILC2s play a central role in driving the cellular changes in the airways of asthmatic subjects. ILC2s are increased in severe asthmatics with uncontrolled inflammation despite being on the highest doses of accepted therapies like oral and inhaled steroids. Finding pathways that control ILC2s may provide additional therapies to control severe asthma.
Dental personnel are high risk professions in contracting and disseminating COVID-19 due to their transmits through respiratory droplets, dental personnel are at high risk of being exposed to the virus if an asymptomatic
patient comes to their clinic. However, limited studies have been performed on the characterization of aerosols generated during dental procedures, how far these aerosols may travel in the clinic, and if they accumulate during the day.
Through historical research, I examine the role of queer history to demonstrate how, and in what ways, oppression evolves into resistance. Focusing on visual culture, such as photographs, home video’s and films, as well as ephemera, letters and personal papers, the goal is to shed light on the dark corners of queer history. By illuminating historical pain and trauma, the intention is to reveal the resilience of previous generations, and where negative affects inform locations of recuperation.
In hospitals, surface disinfection is critical in reducing the spread of disease and the risk of nosocomial infection. In research institutions, where disinfection practices are less rigorous, fomite control is critical in keeping students, faculty and staff safe. Ultraviolet germicidal irradiation (UVC) is an effective disinfection technology that is widely used in hospitals but relies on manual operators.
Neurodegenerative diseases such as Frontal lobe dementia and ALS are difficult to diagnose early, at which point, symptoms might not be clearly noticeable and disease has already caused severe brain damage. Research on new strategies for earlier diagnosis is among the most active areas and the hope is to discover an easy and accurate way to detect neurodegenerative diseases before irreversible brain damage or mental decline has occurred. Identification of imaging biomarkers will be critical for assessment of disease and improves diagnostic accuracy.