Building Rural Research Capacity through Mobilizing Local Thinking: A Strength-Based Approach to Rural Innovation

Healthcare innovation in Canada is an important priority of health systems. Innovation leads to adaptability of health services, a trait which allows them to maintain fidelity of care in the face of stress. The COVID-19 pandemic was a severe system stressor, which saw a diversity of responses across the Canadian health system.

Development of a specific targeted therapy for hepatocellular carcinoma - Year two

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-relateddeaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseasessuch as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer cannot tolerate therapydue to inadequate liver function.

The development of an online shopping browser extension that empowers consumers to choose brands based on ethical certifications and company practices

Over the last 20 years, online shopping has been steadily increasing, and recently doubled since the start of the coronavirus pandemic. Shoppers have also become more ethically conscious and interested in fair trade, sustainability, the source of goods, and company working conditions and taxes. However, for the average online shopper, the ability to make ethical choices is limited as the necessary information can be difficult to find.

Efficacy of mental well-being interventions provided by CheckingIn, a smart device application

Smart device applications show great promise as a means to improve the mental health and well-beingof users. CheckingIn is one such app. CheckingIn monitors self-reported daily mood states of users andsuggests exercises to improve user’s mental health and well-being. Although the app’s well-being programs arescientifically informed, there is a general lack of research investigating how effective such apps are in improvingmental health. Therefore, CheckingIn requires more research to examine the effectiveness of their app’s mentalhealth programs.

Neural and behavioral correlates of accidental cannabis poisoning and potential treatments using cannabis-based drugs

Following the legalization of cannabis in Canada, the incidence of accidental exposure of children and pets to cannabis-containing products including foods is rising, leading to an increase in the number of cannabis poisoning cases being reported. The current treatment for cannabis poisoning generally involves monitoring and detoxification, which is not very effective, emphasizing the need for novel therapeutics for its management.

Development of a novel automated device to detect lymph nodes in surgical pathology (cancer) specimens

Inaccurate staging of colorectal cancer contributes to poor patient outcomes and increased healthcare costs. The current staging process involves a manual and time-consuming search by pathology staff for lymph nodes (LNs) in surgically removed fatty tissues. These LNs are then investigated to determine if the cancer has spread, which informs treatment decisions. We developed a novel robotic system that leverages ultrasound imaging to automatically scan and mark locations of LNs for dissection by pathology staff.

Optimization and development of a drug screening assay using Neurescence’s ChromatoneTM Technology

The mammalian brain constitutes different neuronal cell-types that form local and long-range connections to constitute brain circuits. To remove the technological barrier to enable neuroscientists to gain knowledge on behavior-related dynamic changes of the brain and understand the interaction of complex neuronal circuits, we aim to develop a novel imaging system. It enables simultaneous monitoring and stimulating subpopulations of neurons in multiple brain areas in behaving subjects.

Adoption and enhancement of a primary care management pathway for obstructive sleep apnea: an implementation evaluation project

A clinical pathway for primary care Obstructive sleep apnea (OSA) management has been developed in Calgary to address specific barriers to OSA management by primary care physicians (PCPs) that were identified in a series of stakeholder consultation activities. This study’s primary goal is to maximize use of the clinical pathway to support evidence-based primary care OSA management. The results of this study will support more effective implementation of the pathway in the Calgary Zone and facilitate its scale and spread across Alberta.

Validating an automated speech assessment pipeline for use with individuals with amyotrophic lateral sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects many parts of patients’ lives, such as the abilities to think, move, and speak. Speech problems in ALS can have a substantial effect on patients’ quality of life. They are also related to faster disease progression and shorter survival time. It may be possible to detect the onset of ALS head and neck muscle problems early using speech recordings, which could improve planning of care for ALS patients. Speech recordings may also be useful measures for ALS clinical trials.

Impact of dietary macronutrient content on energy balance and metabolism in lean and obese cats

Obesity is a detrimental disease that affects up to 60 % of domestic cats in North America. It is generally accepted that diet plays a fundamental role in the development of obesity in cats. However, few research studies investigate the role of macronutrients, protein, carbohydrates, and fats, in obesity. The aim of the present study is to evaluate how a low carbohydrate diet may benefit both lean and obese cats compared to both a low protein and a low fat diet, which each have a higher carbohydrate content.

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