Physiological assessment of cochlear and auditory nerve integrity in children suspected of auditory processing disorder - Year two

Nearly 2 % of school-aged children face difficulty in understanding speech in the presence of background noise. These children are often referred to audiology clinics for a central auditory processing (CAP) assessment. The purpose of the referral is to rule out an auditory processing disorder (APD). The American Speech-Language-Hearing Association recommends to include electrophysiological measures to assess the neural integrity in children sAPD. However, less than 15 % of audiologist include the electrophysiological measure in their battery of assessment.

Turning off the “switch”: Preserving the analgesic actions of the endogenous opioid pathway in IBD

Abdominal pain is a debilitating symptom for many patients with inflammatory bowel disease (IBD). An endogenous opioid system emerges in the intestinal tissues during chronic inflammation that acts to dampen such pain and could prevent the need for strong opiate drugs like morphine that can cause serious side effects. However, we have discovered that psychological stress, common in patients with IBD, can block the beneficial analgesic actions of these endogenous opioids and paradoxically can cause them to actually stimulate rather than relieve pain.

Detection of insulin using a novel capturing system

Insulin is a hormone released from the pancreas, which controls the level of glucose in blood. Diabetes is a disease characterized by a lack of insulin production or impaired insulin action. Here, we propose the development of a novel system based exclusively on the measurement of insulin using capturing molecules with high affinity to insulin. This method will provide an affordable and simplified method to be used not only in point of care but also by the patient at home.

A novel therapeutic drug for selective treatment of castration-resistant prostate cancer with MTAP deficiency

Chemotherapy is currently the most effective approach for treatment of advanced cancer. However, chemotherapeutics do not differentiate between malignant and normal cells, and lead to serious side effects. Recent findings indicate that a substantial proportion of cancers, as distinct from normal tissue, are deficient in an enzyme called methylthioadenosine phosphorylase (MTAP).

Story through Mechanics - the design and evaluation of engaging narrative through the use of non-cinematic, mechanics-based techniques in casual games

There are many examples of video games that have successfully used cutscenes and in-game dialogue to deliver engaging stories. But there is one market segment where story hasn?t been a focus, namely casual games. Given such games are primarily intended for a broader audience, have a much smaller budget, and typically focus on short experiences - such as solving puzzles, there may be no real need for story. But there have been some standout casual games that have used setting, theme and emotion very effectively, without the use of heavy scenes or dialogue.

Mechanisms of the relationship between ageing and dementia.

As our population ages, the burden of dementia is growing. Alzheimer's disease (AD) is the most common cause of dementia; currently we do not have any disease-modifying treatments for AD. There is motivation to better understand the mechanisms of AD development and expression to control the burden of disease.

Frailty is related to neuropathological features of AD (i.e. plaques and tangles) and clinical dementia. Frailty and AD-type dementia share many risk factors and clinical features.

Development of a SEMA3C targeted therapeutic for treatment of clear cell renal cell carcinoma, lung cancer, breast cancer and colorectal cancer

The major focus of this proposal is to perform preclinical studies to support clinical development of a novel inhibitor for treatment of different caners such as breast, lung, colorectal and kidney. We have recently developed a novel therapeutic protein that selectively inhibits multiple pathways for treatment of advanced prostate cancer.

Development of a novel stem cell-seeded extracellular matrix for treatment of chronic wounds

The bedsore or pressure ulcer is a serious health problem that affects many individuals with spinal cord injury (SCI). These ulcers mostly develop on skin that covers bony prominences of the body, such as the hips and tailbone. Pressure ulcers are often very difficult to treat and not only negatively affect patients’ health, but also have profound impact on their quality of life. This speaks to the need for finding more effective treatment methods to address this problem. Our aim in this research project is to find a novel method to improve the healing of pressure ulcers.

A Pilot Clinical Study of Treating Pressure Ulcers in patients with Spinal Cord Injury

Pressure ulcers are among the top five leading causes of re-hospitalization in patients with spinal cord injuries (SCI). Unfortunately, current conventional prevention and treatment methods have neither decreased the prevalence of these ulcers nor significantly improved their outcomes. To address this difficulty, here, we will test the efficacy of our new liquid skin substitute to fill up the non-healing wounds where the skin solidified and promotes the healing process. Our plan in a pilot study is to treat 12 patients who pressure non-healing wounds did not heal in the previous 3 months.

Qualitative Data Collection for Development of an Electronic Application to Promote Home-Based Self-Care in Older Heart Failure Patients: Patient and Informal Caregiver Perspectives

Heart failure (HF) is one of the leading causes of hospitalization and rehospitalization in older adults, yet the majority of HF-related readmissions are preventable if patients can manage their treatment at home. One method to help patients who require extra assistance in following their treatment is through mHealth applications. However, these applications are not usable for many older patients due to their complicated design.