Evaluation of the CACE Homecare Curriculum

In January 2016, the Centre for Ambulatory Care Education (CACE) at Women’s College Hospital completed the Homecare Curriculum. This online, simulation-based program is designed to help personal support workers, nurses, and rehabilitation professionals provide better care for older adults who wish to stay in their homes. The program presents learners with 3 virtual home environments and 3 patient profiles. Alone, or with a team, users navigate these virtual homes, learn about home-based care and complete quizzes that test their comprehension of the material.

Pressure Ulcer Biobank from Spinal Cord Injury Patients

Pressure ulcers (PUs) are a major health problem in people with spinal cord injuries (SCIs). PUs increase hospital admissions, with 25% of SCI treatment cost linked to PU management. Currently, treatment is limited and new therapeutic options are required. Wound fluid from PUs is invaluable for researchers as it allows a detailed study of the disease. However, no system is in place to systematically collect and store SCI PU wound fluid in British Columbia. In response, the aim of this proposal is to collaborate with the Rick Hansen Institute (RHI) to establish a PU biobank.

In-vivo translation of neuronal cell regeneration/reprogramming protein in mouse with chronic spinal cord injury

Chronic spinal cord injury (SCI) is a debilitating disease with enormous economic and personal impact. To date there is no approved treatment that can repair the severed nerves found in SCI. The research project entails translational development of an early stage experimental protein drug candidate that has shown remarkable ability to trigger dormant human stem cells to rapidly differentiate into functional neuronal populations. Both the drug candidate’s safe dosage range and efficacy in regenerating neurons at the site of injury will be studied.

Genomics profiling of peritoneal mesothelioma and patient-derived xenograft models for in vivo biomarker validation

Peritoneal Mesothelioma (PM) is a rare type of cancer affecting the protective membrane surrounding the abdominal cavity and the second most common type of mesothelioma, consisting about 10-20% of the diagnosed cases. The underlying cellular and molecular mechanisms of peritoneal mesothelioma pathology are greatly understudied. In this proposal, we aim to enhance the current knowledge of PM pathogenesis and explore therapeutic treatments for it.

The I-Score Study: The development and validation of a patient-reported measure of antiretroviral therapy’s interference with life.

Many HIV-positive persons on HIV medication have trouble taking this medication as prescribed by their doctor (treatment adherence). This threatens the long-term ability of the drugs to preserve a patient’s health. For 1 in 5 in Canada, their medication does not work, in part because of adherence problems. Furthermore, doctors and their HIV-positive patients do not always discuss treatment difficulties and how to resolve them in sufficient depth. The I-Score Study is a 24-month research project that will develop a questionnaire to be filled out by patients as a part of routine HIV care.

Low-dose ionizing radiation and health

This project involves three streams, all focusing on the effects of low-dose ionizing radiation. The first stream examines the effects of single ion irradiation using the Microbeam at McMaster University. Preliminary biological research will be conducted on human cell lines using standard radiobiological endpoints including DNA double strand break foci and micronuclei formation. The second stream is a clinical trial assessing whether low-dose half-body irradiation can stimulate immunity and reduce recurrent prostate cancer.

Discovering the mechanism of action of a novel immunotherapy, Cat-SPIRE, using a network analysis

Allergic rhinitis is an inflammatory condition of the nasal passages induced after allergen exposure in sensitized individuals. Approximately 20-25% of Canadians suffer from allergic rhinitis, with cat allergy affecting up to 15% of people with allergic rhinitis and/or asthma. Although existing immunotherapies have some effectiveness, these have safety problems and require long-term treatment.

Defining cell therapies using CNS tissue sources in living Parkinson's Disease patients

There is a critical need for new therapies for Parkinson’s Disease (PD), a devastating neurodegenerative disease. Current therapies for PD treat disease symptoms, but do not provide a cure. The ability to generate patient brain-derived cells may rapidly advance development of personalized therapies for PD and other incurable neurological disorders. This study will use brain samples from living patients with PD to develop viable human cells specialized to deliver deficient brain chemicals that restore and protect neurological function.

Intracellular growth of Mycobacterium tuberculosis: prospects for drug discovery

The success of Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), lies in its ability to primarily infect, reside, and multiply in the lungs of patients. Mtb infects white blood cells termed alveolar macrophages and hides from the host immune response as well as from many antibiotics used for treatment, creating additional challenges for anti-TB drug discovery. With the increasing prevalence of multi- and extremely- drug-resistant tuberculosis in several countries, there is a pressing need for new drugs against Mtb.

Tailoring Mesenchymal Stromal Cell Therapy to Rescue Marginal DCD Livers for Transplantation

Today 25% of patients listed for liver transplantation die waiting for a liver to become available. The donor organ pool could be expanded by rescuing the 50% of livers donated after cardiac death (DCD) that are discarded due to the injury caused by prolonged periods of warm ischemia during organ retrieval. Mesenchymal Stromal Cells (MSC) reduce inflammation and promote tissue repair.