Signal Parameter Estimation and Tracking During Atrial Fibrillation Using a Bayesian Time-Delay Estimator

AF is an irregular heart rhythm resulting from abnormal electrical impulses and is the most common cardiac arrhythmia encountered in clinical practice. Ablation therapy has been used to eliminate areas responsible for maintaining the arrhythmia using radiofrequency energy. Targeting the culprit regions usually require accurate estimation of activation times in IEGM recordings. The conventional time domain methods fail to present a precise activation detection method and depend on parameters set by an operator.

Assessment of the Neonatal Lung Using Structural and Functional MRI

Currently available diagnostic imaging tools, such as chest radiography and computed tomography, are inadequate for assessing the lungs of preterm neonates. There is considerable interest in using magnetic resonance imaging (MRI) to monitor lung development in neonates longitudinally, since it is a non-invasive and non-ionizing imaging modality. MRI can potentially detect complications at an early stage and improve outcomes by monitoring the effectiveness of therapy, however, images typically suffer from poor signal and organ motion.

Assessment of biomarkers for the non-invasive diagnosis of male infertility

Infertility is a health issue that affects over half a million Canadian of childbearing age. Half of these cases are related to male reproductive dysfunctions. While semen analysis provides information about some causes of male infertility, about thirty percent of these cases remains unexplained. In this context, the main goal of our project is to assess the potential of target molecules, which are secreted from the internal organs of the male reproductive system into the seminal plasma, as biomarkers for the non-invasive diagnosis of infertility.

Novel Cell-surface Engineering Methods to Increase Immune-tolerance of Allogenic Cell Transplantation

Blood transfusion is required for surgery, for the treatment of traumatic accidents and for patients with disorders that require lifelong transfusion therapy. However, when patients receive “mismatched” blood transfusion, their immune system will attack and destroy red blood cells with surface sugars and proteins that differ from their own. This results in massive immune responses in patients, causing shock and even death.

Effect of Different Carbohydrate Sources on Starch Fractions and Glycemic Index in Commercial Extruded Dog Diets

Obesity and diabetes are leading nutrition-related disorders among pets in North America and have significant impacts on animal morbidity and mortality. The glycemic index, a measure of post-prandial blood glucose response, has been shown in humans to significantly impact glucose control, insulin sensitivity, weight management, and chronic disease risk. In pets, the effects of carbohydrates on health is an area of debate, though there is currently a lack of data to back up claims.

A Computational Modelling Framework for Evaluation of Pandemic Vaccine Strategies

Medicago, a clinical-stage biopharmaceutical company, has the potential to rapidly develop a vaccine in response to a newly sequenced influenza strain, allowing for large-scale vaccination of the population very early during a pandemic. The company would like to know how many doses of vaccine is required and what distribution strategies should be used to maximize population-wide benefits of vaccination in the event of an influenza pandemic.

The design and evaluation of a wearable technology as an effective tool for promoting early childhood physical literacy development

With childhood obesity and inactivity on the rise at an alarming rate, many government, education, and health agencies are promoting the development of physical literacy to combat this “epidemic.” The concept of childhood physical literacy refers to the development of fundamental movement skills that permit a child to move confidently and with control, in a wide range of physical activities. Wearable technologies have been quickly gaining in popularity, with devices and apps that can track fitness, sleep patterns, mood and even air quality.

Characterization of Naturally-Occurring Neuropathic Pain in Dogs

Clinical experience demonstrates that canine patients commonly suffer from neuropathic pain and little is known to address this issue. Our study aims to investigate different tools for the diagnosis and treatment of neuropathic pain. Forty dogs with naturally-occurring neuropathic pain will be included in a prospective, randomized, masked clinical trial using appropriate inclusion and exclusion criteria.

Perpetual Nomads: an exploration of indigenous narratives and imagery through contemporary and experimental mediums

The goal of the Perpetual Nomads project is to make illustration depicting many indigenous and environmental issues through traditional art media and digital media. The team will be exploring the viability of creating Mixed Reality interactive experiences to increase the awareness, empathy, egalitarianism and environmental concern in users through these illustrated narratives. Since people use new technologies and traditional arts for expressing themselves in so many ways, its crucial for youth to be exposed to powerful ideas relating to consciousness, sustainability and connectivity.

Oncolytic HSV-1 (oHSV-1) for treatment of prostate cancer

This project is to use genetic engineered “cold-sore” virus to treat prostate cancer. The virus is engineered to reduce its toxicity to normal tissues but can specifically attack and kill tumour cells. Meanwhile, the virus releases a group of anti-tumour immune stimulating factors to activate immune system to eliminate prostate tumour. This project will use a unique prostate tumour mouse model to test the virus.