Investigation of the role of macrophage and smooth muscle cell sub-phenotypes in human atherosclerosis

Providence Healthcare has established a reputation as one of the leading centres for cardiovascular research and treatment in Canada. Pfizer Global Pharmaceuticals Canada is a major provider of pharmaceuticals used in cardiovascular treatment, and has an active research agenda aimed at improving the effectiveness of non]invasive diagnosis and treatment in this field. Pfizer and Providence Healthcare are collaborating on this research in order to develop more effective pharmacological treatments for atherosclerosis.

Left Ventricular Septal Pacing Through Trans-Ventricular Septal Approach - A Feasibility Study

It is well known in Cardiology that chronic right ventricular apex (RVA) pacing (using a pacemaker to regulate heart rhythm by pacing the lower chamber of the heart near the base) might be detrimental to heart function. Right Ventricular Apex (RVA) pacing is the most commonly used for patients. Alternate sites such as right ventricular (RV) pacing, including right ventricular septum and right ventricular outflow tract (RVOT), have not been shown to be definitely superior over RVA pacing.

Palatable Puree: Improving weight status and quality of life among older persons needing dysphagic food products

People with swallowing disorders must eat pureed or minced texture foods to eat safely. However, the process of pureeing or mincing greatly reduces the food’s appeal, often degrades its nutritional quality and can lead to undernutrition. New reformed modified-texture food products have been developed specifically for people with swallowing disorders.

Promoting Healthy Lifestyles with Disease Simulation Models in Community Pharmacies: The Healthy Option Study/L’etude Option Santé

The primary objective of this study is to demonstrate the feasibility of training graduate students, with at least a bachelor’s degree in health sciences or a related science, to complete health screenings in community pharmacies. These screenings will include completion of a diabetes and CVD risk profiles developed by Clinemetrica and the McGill Cardiovascular Health Improvement Program (CHIP) teams and currently available on the web at www.chiprehab.com and www.myhealthcheckup.com.

Adipocyte Dysfunction as a Cause of Obesity-Induced Pathophysiologies: Accelerated Cellular Impairments in Individuals of South Asian Descent

At similar levels of obesity, individuals of South Asian descent (SA) are at greater risk than individuals of European Caucasian (EC) descent for developing type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). We hypothesize that in SA individuals, the morphology and functions of individual fat cells within fat tissue are altered, such that they are enlarged, inflamed and express altered levels of proteins called adipokines, which induce insulin resistance at other body organs, leading to T2DM and CVD.

Improving the Nouse® Perceptual Vision Interface for Individuals who have a Physical Disability

Nouse® software technology is a unique Canadian patented technology that uses advanced Video Recognition algorithms to allow a computer user to operate a computer hands‐free using the nose )or any other part of the body). Essentially, the Nouse® allows an individual to use their nose as a mouse. Over the past 4 years, a partnership between the University of Ottawa, Bruyère Continuing Care and IVIM Inc. has been working on refining this technology to ensure it is suitable for a physically disabled population.

Enhanced Child Safety in Automobiles- Knowledge & Technology Transfer

This project was in partnership with AUTO21. The focus of the research project is to raise awareness and knowledge of the public about the importance of booster seats for children aged 4-9. The specific objective of the internship is to evaluate the impact of Canadian booster seat legislation on motor vehicle occupant fatalities and injuries, especially spinal cord injuries, amongst children aged 4-9.

Development of SCODA DNA Extraction for Forensics Applications.

Nucleic acid analysis in forensic science is a major focus for DNA‐based identification in case‐work samples. Approximately 5% ‐ 10% of samples are known to fail as a result of contaminants carrying through the purification process, or as a result of insufficient yield in the DNA extraction step. Whereas, most crime scene exhibits produce meaningful results, inhibitors, minute traces of DNA, degraded DNA, and environmental insults, reduce the investigative potential of some of the most crucial exhibits.

Investigating methods of long-term follow-up for patients with Metabolic Syndrome

This project was in partnership with the Canadian Obesity Network. Providence Healthcare has estrablished a reputation as one of the leading centres for cardiovascular research and treatment in Canada. Providence Healthcare and AstraZeneca, a research-based pharmaceutical company, are interested in furthering science and improve patient outcomes. The purpose of this study is to determine the best method of long term follow up for patients with Metabolic Syndrome once they have completed an intensive lifestyle modification program.

Weight Management in Morbidly Obese Patients

Our objective is to examine the physical and behavioral characteristics of severely obese patients at the Wharton weight management clinic. We will utilize the patient records at enrollment to characterize this cohort, and administer additional questionnaires that are not routinely given by the clinic that will be completed by patients on a voluntary basis. During the internship, the students will be trained to conduct some of the baseline assessments at the first patient visit.

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