Improving vaccine production with novel drugs

Vaccination is the most effective method for the prevention of a wide range of human illnesses.  Vaccines are currently prepared by growing live virus strains in chicken eggs.  New strategies are very much needed to improve the speed and efficiency of virus production, especially during disease outbreaks.  Recently, Chem Virion has identified new drugs which can significantly boost the growth of viruses.  We propose to use these drugs to improve vaccine production.  We will focus on using these drugs to increase the production of the swine flu (or H1N1) vaccine in cells grown in the laborat

Course of immune responses generated by live Salmonella vaccine in pigs

Salmonella is the second most frequent cause of foodborne illness in Canada and pork is one of sources for human salmonellosis.  Salmonella has also the potential to cause clinical disease in pigs.  Salmonella is commonly found on Ontario swine farms.  Thus control strategies should be implemented.  Vaccination appears to be one of the most promising approaches.  In Canada, there is currently available a live Salmonella Choleraesuis vaccine for use in pigs and a live Salmonella Typhimurium vaccine for use in poultry.  However, the course of immun

Characterization and amplification of blood cells derived from human dermal fibroblasts

Recently it was shown that cells taken from adult skin could be converted to cells possessing “stem-cell-like” characteristics by a process called cellular reprogramming.  However, the use of these cells is limited by our understanding of how to derive mature and functional cells, such as blood cells that could be used for disease treatment.  We previously showed the ability to generate mature blood cells directly from human skin fibroblasts without establishing a “stem cell-like” state, providing a safer option for cell-replacement therapies.  Our current project proposes to characterize t

Investigation of the role of macrophage and smooth muscle cell sub-phenotypes in human atherosclerosis

Providence Healthcare has established a reputation as one of the leading centres for cardiovascular research and treatment in Canada. Pfizer Global Pharmaceuticals Canada is a major provider of pharmaceuticals used in cardiovascular treatment, and has an active research agenda aimed at improving the effectiveness of non]invasive diagnosis and treatment in this field. Pfizer and Providence Healthcare are collaborating on this research in order to develop more effective pharmacological treatments for atherosclerosis.

Left Ventricular Septal Pacing Through Trans-Ventricular Septal Approach - A Feasibility Study

It is well known in Cardiology that chronic right ventricular apex (RVA) pacing (using a pacemaker to regulate heart rhythm by pacing the lower chamber of the heart near the base) might be detrimental to heart function. Right Ventricular Apex (RVA) pacing is the most commonly used for patients. Alternate sites such as right ventricular (RV) pacing, including right ventricular septum and right ventricular outflow tract (RVOT), have not been shown to be definitely superior over RVA pacing.

Palatable Puree: Improving weight status and quality of life among older persons needing dysphagic food products

People with swallowing disorders must eat pureed or minced texture foods to eat safely. However, the process of pureeing or mincing greatly reduces the food’s appeal, often degrades its nutritional quality and can lead to undernutrition. New reformed modified-texture food products have been developed specifically for people with swallowing disorders.

Promoting Healthy Lifestyles with Disease Simulation Models in Community Pharmacies: The Healthy Option Study/L’etude Option Santé

The primary objective of this study is to demonstrate the feasibility of training graduate students, with at least a bachelor’s degree in health sciences or a related science, to complete health screenings in community pharmacies. These screenings will include completion of a diabetes and CVD risk profiles developed by Clinemetrica and the McGill Cardiovascular Health Improvement Program (CHIP) teams and currently available on the web at and

Adipocyte Dysfunction as a Cause of Obesity-Induced Pathophysiologies: Accelerated Cellular Impairments in Individuals of South Asian Descent

At similar levels of obesity, individuals of South Asian descent (SA) are at greater risk than individuals of European Caucasian (EC) descent for developing type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). We hypothesize that in SA individuals, the morphology and functions of individual fat cells within fat tissue are altered, such that they are enlarged, inflamed and express altered levels of proteins called adipokines, which induce insulin resistance at other body organs, leading to T2DM and CVD.

Improving the Nouse® Perceptual Vision Interface for Individuals who have a Physical Disability

Nouse® software technology is a unique Canadian patented technology that uses advanced Video Recognition algorithms to allow a computer user to operate a computer hands‐free using the nose )or any other part of the body). Essentially, the Nouse® allows an individual to use their nose as a mouse. Over the past 4 years, a partnership between the University of Ottawa, Bruyère Continuing Care and IVIM Inc. has been working on refining this technology to ensure it is suitable for a physically disabled population.

Enhanced Child Safety in Automobiles- Knowledge & Technology Transfer

This project was in partnership with AUTO21. The focus of the research project is to raise awareness and knowledge of the public about the importance of booster seats for children aged 4-9. The specific objective of the internship is to evaluate the impact of Canadian booster seat legislation on motor vehicle occupant fatalities and injuries, especially spinal cord injuries, amongst children aged 4-9.