Nucleic acid analysis in forensic science is a major focus for DNA‐based identification in case‐work samples. Approximately 5% ‐ 10% of samples are known to fail as a result of contaminants carrying through the purification process, or as a result of insufficient yield in the DNA extraction step. Whereas, most crime scene exhibits produce meaningful results, inhibitors, minute traces of DNA, degraded DNA, and environmental insults, reduce the investigative potential of some of the most crucial exhibits.
This project was in partnership with the Canadian Obesity Network. Providence Healthcare has estrablished a reputation as one of the leading centres for cardiovascular research and treatment in Canada. Providence Healthcare and AstraZeneca, a research-based pharmaceutical company, are interested in furthering science and improve patient outcomes. The purpose of this study is to determine the best method of long term follow up for patients with Metabolic Syndrome once they have completed an intensive lifestyle modification program.
Our objective is to examine the physical and behavioral characteristics of severely obese patients at the Wharton weight management clinic. We will utilize the patient records at enrollment to characterize this cohort, and administer additional questionnaires that are not routinely given by the clinic that will be completed by patients on a voluntary basis. During the internship, the students will be trained to conduct some of the baseline assessments at the first patient visit.
High dose chemotherapy treatment for lymphoma is followed by the infusion of patients’ own bloodforming stem cells to restore the function of the bone marrow. Canada Blood Services provides critical support in processing and storing these essential stem cell products at very low temperatures. On occasion, the recovery of blood cells after the transplant is delayed, increasing the risk of infections and bleeding complications. In many cases, it is not known why there is delayed engraftment.
Cognitive function changes as people age, and for the most part, these changes are not for the good. Not everybody declines with the same rate; however, even people with cognitive impairment can experience different degree of decline. It is also known that a significant proportion of people can remain stable for a time or even improve. The previous statistical and analytical techniques mainly ignored these cases or considered them as diagnosis misclassifications or measurement errors, or insignificant fluctuation.
Preventing a brain aneurysm from bleeding is an important minimally invasive procedure. It involves specialized training to develop skills in manipulating a tiny tube from the groin artery into the brain. This is performed using highly specialized imaging/X-ray equipment. Once the tube is guided into the brain aneurysm, small coils are positioned within the aneurysm to prevent it from bleeding. The goal of this internship is to investigate the efficacy of this technique in treating one of the most common types of brain aneurysms located at the posterior communicating artery.
Susceptible individuals for inflammatory diseases could be targeted for either preventative measures or care if we could identify them by obtaining their genetic code. However, to date, there is no effective method of discovering which of the more than 5 million genetic variants are important in determining disease susceptibility. A common approach is to test every genetic variation, in every patient, for its correlation with some disease (called Whole Genome Association orWGA), but this is extremely expensive and slow.
After a ligament injury to the knee, clinicians must decide on an optimal treatment for their patient. In most cases, they prescribe either conservative therapies (physiotherapy with or without orthotics) or surgery (which allows doctors to use two different grafts). The Centre du genou Emovi proposes a biomechanical assessment to better understand the functional status of the knee and to determine more accurately the appropriate treatment option.
The internship project will work to deliver a weight loss protein that will combat obesity. The intern will coat DNA for the protein with a natural substance that can be delivered orally or through surgery. If successful, the team expects to see the presence of this weight loss protein in the blood of the specimens. Moreover, the levels should increase after meals and this should encourage less eating and weight loss. enGene, a biotech company specializing in DNA delivery to the gut, will provide the training necessary for this project.
Frantic Films, headquartered in Winnipeg, MB, has developed a reputation for creating innovative, custom built R&D solutions. The intern’s research project will straddle both the worlds of microbiology and physical simulation in order to create a dynamic, physically-based model of the cytoskeleton within a cell.