Privacy Preserving Federated Learning

5G, cloud and IoT confederation vision is to revolutionize the internet by fostering billions of interconnected mobile and embedded devices, sensors, and services, exchanging information in order to build smart, self-conscious autonomous environments. Yet, the ubiquity and value of connected devices and their applications cannot hide their security and privacy challenges. The enormous amount of data sensed and communicated over a fusion of heterogeneous networks, became an increasingly attractive target for cybercriminals.

The role of dairy consumption on variations in response to lifestyle factors in youth and adults

Obesity has increased drastically since the late 1970s and unhealthy eating habits are just one of the causes. Some studies have shown that consuming dairy products such as yogurt helps control body weight in both adults and children. However, factors such as genetics and environment (e.g. dietary and lifestyle factors) may play a role in this response as children who have an obese parent or live in low-income neighborhoods are more likely to become obese adults.

A novel therapeutic drug for selective treatment of castration-resistant prostate cancer with MTAP deficiency

Chemotherapy is currently the most effective approach for treatment of advanced cancer. However, chemotherapeutics do not differentiate between malignant and normal cells, and lead to serious side effects. Recent findings indicate that a substantial proportion of cancers, as distinct from normal tissue, are deficient in an enzyme called methylthioadenosine phosphorylase (MTAP).

Investigating the Role of Cannabis Derived Phytocannabinoid Formulations for the Development of Novel Mental Health Pharmacotherapies

Cannabinoid phytochemicals derived from the marijuana plant are increasingly being recognized for their potential in treating a wide variety of mental health conditions. For example, specific compounds found in marijuana such as THC and cannabidiol (CBD) are showing promise as pharmacological treatments for disorders including schizophrenia, anxiety, depression and PTSD. However, very little is understood regarding the underlying neurobiological and molecular mechanisms by which these treatments may produce their clinical effects.

An Investigation on the Detection of Oil-based Pollutant Spills in Ice-infested Arctic Waters Utilizing Active Microwave Remote Sensing

Climate change continues to shrink the sea ice in the Arctic. Consequently, there is an ever-increasing trend of industrial and shipping activities in the Canadian Arctic. This results into a high risk of accidental or deliberate release of oil-related pollutants in the Arctic waters. Satellite remote sensing is a key component in spill detection as an essential step towards any remediation and cleanup effort. Thus, this project proposes to develop a detection algorithm based on microwave satellite data that can be incorporated into a high-level oil spill alarm system.

Development of Additives in Pellet Form For Asphalt Mixes Containing Recycled Asphalt

In this project, asphalt mix additives in the form of pellets added directly in the mix during mixing will be developed. The pellets will include at least recycled asphalt shingles, but other additives like rejuvenators and warm mix additives will also be tested. Those additives should help to make asphalt mixes with better mechanical properties while using less virgin materials. The compactibility, the workability, the moisture resistance and properties like thermal cracking resistance, rutting resistance and modulus of those modified mixes will be tested.

Mevalonate Cascade Inhibition Sensitizes human Glioblastoma Cells to Temozolomide via Modulation of Autophagy

Glioblastoma multiforme (GBM), also known as glioblastoma and grade IV astrocytoma, is the most common and most aggressive cancer that begins within the brain. There is no clear way to prevent the disease. Typically treatment involves surgery after which chemotherapy and radiation therapy is used. The medication Temozolomide (TMZ) is frequently used as part of chemotherapy. Cholesterol lowering drugs (statins) is recently being considered as a novel and safe approach for combination therapies in many cancers.

Diagnostic screening for conscious awareness in brain injury and disease: Visual component

Since the mid 1970s, medical personnel have used the Glasgow Coma Scale (GCS) as an important tool to rate and describe levels of consciousness. This scale is rudimentary and subjective, often resulting in misdiagnoses in cases where people lack the capacity to communicate. In some unfortunate situations, severe neurological damage can render people unable to move. Inevitably, these people are deemed vegetative when in actuality; many are simply ‘locked in’. For years researchers have used cognitive event related potentials (ERPs) with modified EEG to assess receptive language capacity.

Management of posttraumatic stress disorder: a multiple treatment comparison meta-analysis of randomized controlled trials

Traumatic events such as work related accidents, injuries or assault may result in the development of post-traumatic stress disorder (PTSD). This condition is associated with sleep disruption, nightmares, anxiety, and avoidance of the environment where the traumatic event occurred. Significant proportions of patients diagnosed with PTSD are disabled from working; however, little is known regarding which treatments are most effective for improving functional recovery. Existing research mainly focuses on the effect of treatment for reducing symptoms, and looks at treatments in isolation (e.g.

Implementation of a chip-based MDTMA platform for evaluating prostate cancer treatment response and mode of action.

Prostate cancer will affect 1 in 7 Canadian males. While the number of therapeutic options is increasing, matching each patient to the right therapy remains as the challenge for a personalized approach to patient management. Currently, most of the attention has focused on identifying biological tags that can predict patients response. We have developed an alternative approach that can keep tumor samples alive outside the body to test therapeutic agents directly on the tumor.