Cannabigerol (CBG) for the Management of Crohn’s Disease and its Symptoms - BC-404

Preferred Disciplines: Biopharmaceuticals, Biotechnology, Biochemistry (Masters or PhD)
Project length: Minimum 4 months (1 unit)
Approx. start date: As soon as possible
Location: Whistler, BC and Pemberton, BC
No. of Positions: 1+
Preferences: None
Company: Anonymous

About Company:

We are a cannabis research and emerging biopharmaceutical company. We create cannabis extracts tailored to treat specific conditions and bring them through clincial trials. We have an exclusive partnership with a licensed medical cannabis producer, and we are screening over 20 different types of cannabis extracts for their efficacy in human patients. 

Summary of Project:

Inflammatory Bowel Disease (IBD) is a chronic condition that affects the gastrointestinal tract. IBD consists of two related but distinct diseases – Crohn’s Disease and Ulcerative Colitis (UC). Crohn’s Disease is lifelong and affects the entire digestive system. Cannabis sativa has grown increasingly popular as a potential therapy for IBD. The endocannabinoid system (ECS) is implicated in gut hemostasis, gastrointestinal motility, visceral sensation, and inflammation. Research shows that the modulation of ECS may play a key role in the pathogenesis of IBD, and help patients manage their symptoms such as abdominal and joint pain, cramping, diarrhea, poor appetite, weight loss and nausea (Eisentein, 2015; Storr et al., 2014; Katchan et a., 2016; Ahmad& Katz, 2016;  Naftali et al., 2011). Specifically, the effects of Cannabigerol (CBG), a non-psychotropic cannabinoid, is reported to help treat IBD (Borrelli et al., 2013). The effects of CBG in a murine model of colitis was investigated and results showed CBG reduced colon weight/colon length ratio, myeloperoxidase activity, and iNOS expression; increased SOD activity; and normalized interleukin-1β, interleukin-10 and interferon-γ changes. Therefore, CBG could be considered for clinical experimentation in IBD patients (Borrelli et al., 2013). Moreover, from our own observational study, patients have reported that the use of cannabis helped their IBD and recognize that cannabis and CBG is safe for humans to use in order to manage their IBD.

Therefore, we propose a phase two clinical trial examining the role and effect of CBG on IBD, specifically Crohn’s Disease. We hypothesize that cannabis extracts with a high level of CBG along with retained terpenes will be effective for patients to manage their IBD (Crohn’s Disease).

Research Objectives/Sub-Objectives:

  • Analyze the role that specific cannabiniod (CBG) along with retained terpenes have on Crohn’s Disease
  • Investigate the synergestic role of terpenes and cannabinoids on  Crohn’s Disease
  • Understand mechanistic actions of cannabiniods and potency on the treatment and management of Crohn’s Disease and its symptoms
  • Develop and plan potential medical cannabis interventions (e.g., medication) for the treatment and management of Crohn’s Disease based on data results and further research   

Methodology:

    We propose a phase two clinical trial examining the role and effect of CBG on IBD, specifically Crohn’s Disease. We hypothesize that cannabis extracts with a high level of CBG along with retained terpenes will be effective for patients to manage their IBD (Crohn’s Disease). 

    Expertise and Skills Needed:

    • Must have prior experience organizing,  coordinating,  recruiting and following up with patients
    • Proficient project management, and organizational skills
    • Experience managing sensitive data
    • Excellent proficiency with Microsoft Office, SPSS or another statistics software
    • Excellent prior knowledge of cannabis, cannabiniods and the endocannabiniod system and the regulatory framework associated with medical cannabis
    • Prior experience in leading a reseach team, and partaking in all steps of research including ethics, proposals, and knowledge translation
    • Experience in Clinical Trials (CTA-HC) and patient liason or mointoring.
    • Effective communicaiton skills in oral and/or written form to both internal and external audience
    • Cooperative, and team-oriented and ability to work with tight deadlines while maintaining high standards.

    For more info or to apply to this applied research position, please

    1. Check your eligibility and find more information about open projects.
    2. Interested students need to get the approval from their supervisor and send their CV along with a link to their supervisor’s university webpage by applying through the webform or directly to Noha Gerges.
    Program: