Evaluation of Albumin as a small molecule drug formulation / delivery platform - BC-371
Preferred Disciplines: Biotechnology / Chemistry / Biochemistry - Senior PhD / Post-Doc
Project length: 4 to 6 months (1 or more internship units)
Desired start date: As soon as possible
Location: Vancouver, BC
No. of Positions: 1
Preferences: Work to be carried out in intern’s home laboratory. Language : English
Vancouver based biotechnology company involved in oncology research.
Human serum albumin is a highly prevalent protein in circulation with numerous important physiological roles. One of the roles is binding to small molecules, lipids and drugs to transport them to various locations within the body. nab-Paclitaxel (Abraxane™), a formulation of a chemotherapeutic drug utilizes this feature of albumin to deliver the drug in case of a few different hard to treat cancers.
Background and required skills
The research goal is to understand the drug binding and exchange properties of the drug bound to albumin. We will be looking into the relative level of drug uptake by albumin under different conditions. In particular, what is (quantify) the drug load in protein bound state, characterize exchange properties in solution (including serum) and in the presence of other proteins.
The emphasis will be on the use of various in vitro analytical techniques to characterize small molecule loading in proteins.
Expertise and Skills Needed:
- Analytical Chemistry / Biochemistry
- Protein Science: protein purification, protein characterization
- Handling chemotoxic compounds
For more info or to apply to this applied research position, please