Evaluation of Albumin as a small molecule drug formulation / delivery platform - BC-371

Preferred Disciplines: Biotechnology / Chemistry / Biochemistry -  Senior PhD / Post-Doc
Project length:  4 to 6 months (1 or more internship units)
Desired start date: As soon as possible
Location: Vancouver, BC
No. of Positions: 1 
Preferences:  Work to be carried out in intern’s home laboratory. Language : English
Company: NA


About Company:

Vancouver based biotechnology company involved in oncology research.

Project Description:

Human serum albumin is a highly prevalent protein in circulation with numerous important physiological roles. One of the roles is binding to small molecules, lipids and drugs to transport them to various locations within the body. nab-Paclitaxel (Abraxane™), a formulation of a chemotherapeutic drug utilizes this feature of albumin to deliver the drug in case of a few different hard to treat cancers.

Background and required skills

Research Objectives/Sub-Objectives:

The research goal is to understand the drug binding and exchange properties of the drug bound to albumin. We will be looking into the relative level of drug uptake by albumin under different conditions. In particular, what is (quantify) the drug load in protein bound state, characterize exchange properties in solution (including serum) and in the presence of other proteins.


The emphasis will be on the use of various in vitro analytical techniques to characterize small molecule loading in proteins.

Expertise and Skills Needed:

  • Analytical Chemistry / Biochemistry
  • Protein Science: protein purification, protein characterization
  • Handling chemotoxic compounds


For more info or to apply to this applied research position, please

  1. Check your eligibility and find more information about open projects.
  2. Interested students need to get the approval from their supervisor and send their CV along with a link to their supervisor’s university webpage by applying through the webform