Develop Derived scFv by Random Mutagenesis to Recognize other Proteins: Seeking Post-doctoral Fellow- QC-298

Desired discipline(s): Biochemistry / Molecular biology, Life Sciences, Biology, Microbiology / Immunology
Company: Purinomia with Professor Jean Sévigny (Universite Laval)
Project Length: Longer than 1 year
Preferred start date: As soon as possible.
Language requirement: Flexible
Location(s): Quebec, QC, Canada
No. of positions: 1
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About the company: 

This research project is with Professor Jean Sévigny with the Department of Microbiology-Infectiology and Immunology, Faculty of Medicine, at l'Université Laval. The industry partner is Purinomia: https://purinomia.com. For more information about Professor Jean Sévigny's research, please visit: http://www.crchudequebec.ulaval.ca/recherche/chercheurs/jean-sevigny and http://ectonucleotidases-ab.com. This is for a post-doctoral fellow to work on a project over 2 years. It is expected there will be some training to take place in Boston, MA – to be determined.

Please describe the project.: 

We generated a specific blocking monoclonal antibody to a protein of clinical interest (NTPDases).  We also cloned and expressed the paratope in a scFv construct as a single chain antibody.  The project will be to develop derived scFv by random mutagenesis that will recognize other proteins of the same family and to ameliorate the potency of inhibition of the protein/Ab like.

 Interested candidates can apply directly to Dr. Sevigny’s lab: Jean.Sevigny@crchudequebec.ulaval.ca 

Required expertise/skills: 

Biochemistgry, molecular biology, protein engineering, protein purification, enzymology

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